Using mice deficient in Del - 1, they found that the protein promotes proliferation and differentiation of hematopoetic stem cells, sending more of these progenitor cells down a path toward
becoming myeloid cells, such as macrophages and neutrophils, rather than lymphocytes, such as T cells and B cells.
Not exact matches
In 2011, after spending 8 years as an industry researcher, Arefolov took the seemingly backward step of
becoming a postdoc in the lab of Harvard University chemistry professor Matthew Shair to work on developing a promising — and potentially lucrative — new approach to treating acute
myeloid leukemia.
Myeloid cells are cells that would have
become other blood cells (white blood cells other than lymphocytes, red blood cells or platelets) under normal development.
Resveratrol also decreases phase III protein synthesis and a study showed that in a cell culture this prevented acute
myeloid leukemia cells from
becoming resistant to the chemotherapy drug doxorubicin (24).
Mice and human volunteers who underwent cycles of the Fasting Mimicking Diet had decreased numbers of
myeloid cells, the inflammatory immune cells that
become more numerous as we age, and increased numbers of cytotoxic T cells, which protect the body against viruses and cancer.