Using cells as treatments is powerful, but comes with a number of complications that must be worked out carefully
before human studies are conducted.
Not exact matches
«We suspected that the young are most vulnerable because of their immature immune systems, but we didn't have a lot of hard evidence to show that
before,» said
study lead author Bo Hang, a Berkeley Lab staff scientist who previously found that thirdhand smoke could lead to genetic mutations in
human cells.
As the Danish statistician Bjørn Lomborg has shown in
study after
study, life expectancy is increasing on a global basis, including in the Third World; water and air in the developed world are cleaner than five hundred years ago; fears of chemicals poisoning the earth are wildly exaggerated; both energy and food are cheaper and more plentiful throughout the world than ever
before; «overpopulation» is a myth; and the global picture is, in truth, one of unprecedented
human prosperity.
One of the most helpful ways a congregation can engage in pastoral care is by
studying issues that might create moral dilemmas
before they are brought to the church in the form of real, live,
human beings.
It challenges magic by showing that the powers of nature must be
studied, respected, and obeyed
before they can be employed for the fulfillment of
human wants.
(Here we return to Beauchamp's magnificent
study, from which I must quote an especially illuminating and powerful passage: «God did not so much create the things I am talking about as he spoke them...
before speaking to me about them, so that the
human word might be declared a response to his.
In one of those interesting accidents of timing only a few months
before Magic Johnson put
human sexuality on the national agenda, the Presbyterian Church (U.S.A.) tried to correct this institutional paralysis over sexuality when it considered a
study document designed to confront the inadequacy of both an empty moralism and an arrogant secularity.
Although the results of the
studies in the psychology and philosophy of religion have not yet led to unanimous agreement among the scholars, the present - day knowledge of the place of religion in
human experience is firmer than ever
before.
or a war aginst invaders... if smeone enters ur home and starts taking over it u'll try and get them out by any means possible... Jihad is a war fought if ur country is invaded by outside forces... which is a right for any
human being... one again
before passing judgement yuou might want to get ur facts straight... don't listen to what u're told... God has given u a brain... use it...
study a religion..
Before dismissing Augustine as being ancient, his dilemma as being archaic and his solutions as being irrelevant, it is well that we take a close look at what has been happening in secular education and also at the relationship between
human / social
studies in secular institutions on the one hand and Christian institutions on the other.
The material of our
study of
human nature is now spread
before us; and in this parting hour, set free from the duty of description, we can draw our theoretical and practical conclusions.
At present, there have been no
studies on allergenicity and toxicity of Golden Rice, which should be first established in animal feeding trials
before feeding trials on
humans commence.
However, this needs to be
studied properly in
human controlled trials
before any recommendations can be made.
The NBA will also benefit by gaining scientific expertise from the Gatorade Sports Science Institute (GSSI), which employs scientists who
study how nutrition interacts with the
human body
before, during and after physical exercise.
She
studied Law at the University of Kent
before practising as a barrister from 1985 to 2005, specialising in
human rights law under the guidance of Michael Mansfield.
Wang points out that the current findings are preliminary and that comparing SLC13A5 activity in healthy and cancerous
human liver tissue will be necessary
before studies of this pathway as a cancer drug target should be contemplated.
Mitchell guesses that there will probably be 10 more years of rigorous testing in animals
before moving on to
human clinical
studies.
Most scientists thought that the capability for such symbolic thinking was unique to modern
humans, but a new
study suggests that it dates back to
before the Neandertals.
Its predecessor — dubbed AlphaGo Lee when it became the first computer program with artificial intelligence, or AI, to defeat a
human world champion Go player (SN Online: 3/15/16)-- had to
study millions of examples of
human expert moves
before playing practice games against itself.
«With these system concept
studies, we are taking the next steps to develop capabilities needed to send
humans deeper into space than ever
before, and ultimately to Mars, while testing new techniques to protect Earth from asteroids,» William Gerstenmaier, associate administrator for NASA's
Human Exploration and Operations Mission Directorate.
The data for her
study were taken from the remains of 52 European and Levantine individuals — Neandertals and Upper Paleolithic
humans — from 37 sites dating back to between 500,000 and 12,000 years
before the present.
«
Before this
study, it was not known if it is possible to produce sufficient numbers of these cells and successfully use them to remuscularize damaged hearts in a large animal whose heart size and physiology is similar to that of the
human heart,» said Dr. Charles Murry, UW professor of pathology and bioengineering, who led the research team that conducted the experiment.
«The fact that people with metabolic syndrome had lower bioavailability of vitamin E was expected, but it had never been
studied before and therefore we've had no guidance to make recommendations for that population,» said Richard Bruno, professor of
human nutrition at The Ohio State University and lead author of the
study.
A new
study by Max Kilger, director of Data Analytics Programs at The University of Texas at San Antonio (UTSA) College of Business, is delving into an aspect of cybersecurity rarely explored
before now: the
human component.
The
study also confirms that the «H1» hemagluttinin protein of the new virus derives from the classical swine H1N1 strain, which shares a close common ancestor with the
human H1N1 strain circulating
before 1957 and several lines of evidence show that older people exposed to that virus may have some immunity to the new H1N1.
Coss» paper grew out of a 2015
study in which he and a former graduate student reported that zebras living near
human settlements could not be approached as closely
before fleeing as wild horses when they saw a
human approaching on foot — staying just outside the effective range of poisoned arrows used by African hunters for at least 24,000 years.
«Biofilms were rampant on the Mir space station and continue to be a challenge on the International Space Station, but we still don't really know what role gravity plays in their growth and development,» said Cynthia Collins, Ph.D., principal investigator for the
study and assistant professor in the Department of Chemical and Biological Engineering at the Center for Biotechnology and Interdisciplinary
Studies at the Rensselaer Polytechnic Institute in Troy, N.Y. «
Before we start sending astronauts to Mars or embarking on other long - term spaceflight missions, we need to be as certain as possible that we have eliminated or significantly reduced the risk that biofilms pose to the
human crew and their equipment.»
«This
study suggests Americans» are largely cautious about using emerging technologies in ways that push
human capacities beyond what's been possible
before.»
«We have followed a less potent neutralizing lineage in this particular individual
before, but now we have found a far more potent antibody and have been able to
study its development over six years,» said first author Mattia Bonsignori, M.D., of the Duke
Human Vaccine Institute.
And scientists who conduct
human challenge
studies, which typically involve a few dozen participants, say they have critical benefits: In addition to saving time and money, they can reveal harm caused by a potential drug or vaccine
before it enters large - scale
human efficacy trials.
Regulatory issues must be addressed
before moving to
human studies, Davies said, but the findings published in the August issue of the Journal of Clinical Investigation suggest that it may be possible to manipulate the bacterial residents of the gut — the gut microbiota — to treat obesity and other chronic diseases.
Before moving on to human trials, they will need to study all instances of «off - target» effects: Years before Crispr, the viruses employed to deliver DNA in gene therapy trials occasionally damaged the whole system, causing c
Before moving on to
human trials, they will need to
study all instances of «off - target» effects: Years
before Crispr, the viruses employed to deliver DNA in gene therapy trials occasionally damaged the whole system, causing c
before Crispr, the viruses employed to deliver DNA in gene therapy trials occasionally damaged the whole system, causing cancer.
During her Ph.D., she worked with ancient DNA from a variety of organisms — including whales, koalas, and maize —
before settling on
humans, to
study their evolution.
That challenge is even bigger in the avian world, says Dan Stowell, a computer scientist at Queen Mary University of London who
studied human voice analysis
before turning his attention to the treetops.
While most research
studies begin in test tubes, cells grown in the laboratory and animal models
before moving to
humans, the opposite is true here.
Paleontology
studies such as this can «establish an ecosystem's long - term past
before humans altered it,» says invertebrate paleontologist Sally Walker of the University of Georgia, Athens.
«If we
study humans before, during, and after the plague, we should see how the
human genome responded to these repeated outbreaks and the response in bacteria,» Poinar says.
Ancient DNA
studies had already suggested that
humans from Africa reached Southeast Asian islands
before 60,000 years ago.
Indonesia's enigmatic «hobbits» were no more than average
humans whose small stature, tiny brains, and peculiar anatomy were caused by a severe lack of iodine
before birth, a new
study claims.
The seven - day rainfall total from Harvey was as much as 40 percent higher than rainfall from a similar storm would have been decades ago,
before human activity caused atmospheric carbon dioxide levels to spike, according to a
study published yesterday in Geophysical Research Letters.
Finally, says Evrony, the findings provide a proof - of - principle for a systematic way of
studying how brain cells disperse and migrate during development, «something that has not been possible to do
before in
humans,» he says.
U.C. San Francisco's Julius (who was not involved in the
study) called the new approach simple and clever, but noted that some tweaks of the methodology are needed
before this can become a pain blocker in
humans.
The results need be tested and confirmed in animal
studies before researchers can be sure that HtrA1 is the link between ApoE4 and Alzheimer's in
humans.
If THI continues to show promise as a nutraceutical or food - based drug, medical scientists will head into pre-clinical
studies of effectiveness and safety
before advancing to
human trials.
«
Before jumping into the
human studies, I would like to see some animal
studies,» she says.
After drinking, blood alcohol levels increase much faster and reach higher levels than what would be expected
before surgery, explains Marta Yanina Pepino, an assistant professor in the Department of Food Science and
Human Nutrition at U of I who led the
study.
Ninety - four of the injured individuals elected to enroll in an eight - institution
study that began
before the end of April 2013 through the efforts of Harvard Catalyst, the clinical and translational science center that facilitated a framework for Harvard Medical School - affiliated institutions to speed the review of
human studies.
«What was believed
before our
study was that Europe was the center of the earliest explosion in
human creativity, especially cave art,» says geochemist and archaeologist Maxime Aubert of Griffith University, Gold Coast, in Australia, who led the new
study.
But Sikora's
study «shows that modern
humans already lived in socially fluid societies well
before the origins of agriculture,» says anthropologist Andrea Migliano of University College London.
«The beauty of this
study is that we now have a system in which we can investigate how a signaling cell uses these two genes Yorkie and Scalloped, which have never
before been shown in blood, to direct specific cells to be made,» said Dr. Martinez - Agosto, associate professor of
human genetics.