Interestingly, the first complaints of memory decline occurred on an average of six years
before mild cognitive impairment (a condition that sometimes, but not always, progresses to dementia) was diagnosed, and about nine years before dementia was diagnosed.
Not exact matches
In Alzheimer's disease, this loss of synapses occurs very early on, when people still only have
mild cognitive impairment, and long
before the nerve cells themselves die.
Previous studies have linked levels of inflammatory markers in CSF and blood to
Mild Cognitive Impairment (MCI), and research shows that elevations in inflammatory markers may be present decades
before any AD symptoms appear.
The landmark publications designated three stages of Alzheimer's — preclinical (
before symptoms affecting memory, thinking or behavior can be detected),
mild cognitive impairment and dementia.
Nobody who had
mild cognitive impairment that later on developed Alzheimer's had initial caffeine levels above a critical level equal to having a few cups of coffee several hours
before the blood sample was taken.