Sentences with phrase «behavioral deficits»

That translates to an impaired ability for neurons to receive whatever signals surrounding neurons are trying to send and mice displaying schizophrenia - like behavioral deficits such as impaired cognition and sense of direction.

Developmental dyslexia, characterized by unexplained difficulty in reading, is associated with behavioral deficits in phonological processing.

«Severe behavioral deficits of the left forepaw were evident in all of the mice three days after stroke.

Sequeira, Jeffrey M., et al. «Exposure to Folate Receptor Alpha Antibodies during Gestation and Weaning Leads to Severe Behavioral Deficits in Rats: A Pilot Study.»

Reversals of age - related declines in neuronal signal transduction, cognitive, and motor behavioral deficits with blueberry, spinach, or strawberry dietary supplementation.

Agonists for nuclear receptor Nurr1 enhance its dual functions and improve behavioral deficits in animal models of Parkinson's disease.

It is believed that children with autism who have CFD were exposed to folate receptor alpha antibodies during pregnancy, and research shows that this can cause behavioral deficits including anxiety [14].

We will explore whether the intravenous administration of the recombinant protein is able to reduce Aβ accumulation in the mouse brain and prevent the cognitive and behavioral deficits associated with that pathology.

«3 More than fleshly wisdom or human cleverness is required if one is to encourage a balance of behavioral excellences without eliciting new behavioral deficits.

of whom «displayed behavioral deficits of one sort or another.»

Longer term studies are needed to establish whether the structural changes and behavioral deficits found in the mice last, Stanton says.

After concluding that increased stem cell production in a certain area of the brain had a positive effect on behavioral deficits of Alzheimer's, Prof. Offen has moved to research into the area of the brain that controls memory.

To the researchers» surprise, the mice subjected to both prenatal infection and stress during puberty showed far greater behavioral deficits and cellular changes in brain regions relevant to schizophrenia than those that had been exposed to infection or stress alone.

The study also showed that targeting the activity of the mTOR pathway shortly after birth, a time when neurons are forming connections between these brain areas, can block the emergence of abnormal amygdala activity and social behavioral deficits.

A common assumption about such diseases is that changes in genes skew protein expression in certain neurons, which in turn alters the brain's wiring to cause characteristic behavioral deficits.

Research on cognitive decline and age - related behavioral deficits primarily focuses on morphological and electrophysiological changes in the hippocampus and many studies report age - related deficits in learning and memory due reduced hippocampal synaptic connections and neuron density.

Progressive behavioral deficits in DJ -1-deficient mice are associated with normal nigrostriatal function

We identified dopamine (DA) and GABA cell - type - specific changes in excitatory synapse transmission that converge to reduce DA neuron activity and generate behavioral deficits, including impaired social preference.

It is known that motor abnormalities in CAG 94 KI and CAG 140 KI mouse models are present from an early age, with a delayed onset observed in the CAG 94 KI model as compared to CAG 140 KI; in addition, overt behavioral deficits were observed after 2 years of age in the CAG 140 KI mouse model (Menalled et al., 2003, Hickey et al., 2008).

While some neurophysiological deficits, restored following HDAC4 genetic reduction, are convincingly and dose - dependently restored in HD models following treatment with either compound; we failed to significantly impact behavioral deficits.

Autism Speaks is currently funding a number of studies that examine whether prenatal valproate exposure produces behavioral deficits in animals.

For example, in the United States, youth with a diagnosable mental disorder account for almost 20 percent of the population of children.These children are also more likely to be from low - income families, to be exposed to violence and losses, as well as to have social and adaptive behavioral deficits that make it difficult for them to learn.

Our strategy involved a 3 - month J147 treatment in huAPP / PS1 transgenic AD mice aged to 20 months, an age in which severe behavioral deficits and AD pathology manifest [10].

Over 200 compounds appear to alter Aβ metabolism or behavioral deficits in AD transgenic mice [30] but none have translated into AD therapeutics [98].

Then he began a behavioral assessment of Mrs. S.'s situation, seeking to identify the particular behavioral excesses (e.g., frequent rages) and behavioral deficits (e.g., underassertiveness) that were producing her distress.

Thus, if you neglect these small incremental matters of behavioral deficit and minor excess, you may in time be lured into larger self - deceptions and collusions that will spell disaster.

of the existing literature on sleep deprivation in children confirmed what has long been believed to be true: «inadequate sleep quality and / or quantity can cause sleepiness, inattention and, very likely, other cognitive and behavioral deficits that significantly impact children and adolescents in functional settings.»

These animals showed none of the behavioral deficits usually seen in such offspring, and their brains showed none of the epigenetic changes.

It is well known that seizures produce learning, memory and behavioral deficits, and that they trigger abnormally high activity of two signaling pathways in the brain: the phosphoinositide 3 - kinase (PI3K) and mechanistic target of rapamycin (mTOR) cascades.

«A key aspect of this work is that we've shown that a tactile, somatosensory dysfunction contributes to behavioral deficits, something that hasn't been seen before,» Ginty says.

«In animal models,» Lee explains, «the question we want to ask is, can we reduce the pathology and also rescue cell loss to improve the behavioral deficits?»

«It's [damage to] the right hippocampus that's driving the behavioral deficit,» he says.

«Our results reveal that SOX2 plays an important role in TBI - induced reactive astrocytes and behavioral deficits.

Our findings suggest that frontal network modulation to improve executive and behavioral deficits should be further studied in patients with Alzheimer's disease,» said Rezai, the former director of Ohio State's Neurological Institute who is now leading the Rockefeller Neuroscience Institute at West Virginia University.

They found that GLUT1 deficiency led to diminished glucose uptake into the brain as early as two weeks of age and, by six months of age, neuronal dysfunction, behavioral deficits, elevated levels of amyloid - beta peptide, behavioral changes and neurodegenerative changes.

In the course of screening over 180 mutant mouse strains with a systematic battery of behavioral tests, Dr. Tsuyoshi Miyakawa and his colleagues found that mice with heterozygous knockout of the alpha - isoform of calcium / calmodulin - dependent protein kinase II (αCaMKII) exhibit behavioral deficits and other brain features consistent with bipolar disorder.

Bottom Line: Young mice that received molecularly targeted therapies used to treat brain cancer in human patients sustained cognitive and behavioral deficits, but the deficits were largely reversible through environmental stimulation and physical exercise.

As we have seen, both active vaccination with AFFiRiS» AFFITOPE AFF 1 / PD01A vaccine and passive vaccination with Prothena's AS - targeting mAbs (one of which presumably was humanized to develop PRX002) were effective in rescuing neuronal loss, synaptic degeneration, neuroinflammation, and cognitive and behavioral deficits in two mouse models of synucleinopathies of aging.

When administered intraperitoneally to PDGF - AS mice, this conjugate reduced AS neuropathology, neuronal loss, astrogliosis, and behavioral deficits in the water maze.

Prevention of CTTAS Neuropathtology, Neurodegeneration, and Behavioral Deficits Like AFFiRiS scientists testing AFF 1, [15] the Prothena group selected the mThy1 - AS mouse for in vivo testing of their candidate mAbs.

He also has shown that reducing tau levels, or suppressing the abnormal excitability of these networks with drugs, can both reduce cognitive and behavioral deficits in animal models of Alzheimer's disease.

Based on these results Lemere's team concluded that complement C3, or associated downstream signaling, play an important role in age - related cognitive decline and behavioral deficits.

The field of cognitive neuroscience began with observations that behavioral deficits could occur after injury to the brain.

Indeed, social and behavioral deficits that affect participation in the learning process or access to the learning environment are regarded in much the same way an academic deficit is regarded.