Sentences with phrase «beige fat»

The researchers tested if there was a relation between an increase in beige fat cells and consumption of fish oil.

More beige fat cells and fewer white fat cells could reduce the symptoms or negative health outcomes of metabolic diseases like diabetes, obesity.

The tissue created in this process is called beige fat.

Both brown and beige fat get their color from increased mitochondria that are added in response to cold and other environmental stimuli, he said.

But since white fat cells have very few nerves, how do beige fat cells get the message that it's cold outside?

He adds that further studies are necessary to fully understand how the hormone works in humans, specifically how it relates to brown and beige fat tissue and energy use.

This indicates higher energy consumption in the new, beige fat cells.

It also synced with production of beige fat in obese diabetic subjects.

The study shows that activating the bile acid receptor TGR5 with molecules that mimic the action of bile acids (so called «mimetics») induces a remodeling of white fat cells into beige fat cells.

«Cold exposure prompts body to convert white fat to calorie - burning beige fat.»

In a UT Southwestern Medical Center study, (l - r) Dr. Philipp Scherer, Dr. Yi Zhu, and Dr. Shangang Zhao found interesting anti-diabetic properties in beige fat.

Now that they have a reliable human beige fat cell culture system, Kajimura said, his team will be able to use the system as a screening platform to identify and test small molecules that activate the development, differentiation, and thermogenic (heat - producing) activity of human brown fat.

«We wanted to investigate whether human adults had the ability to transform some white fat deposits into beige fat when they were exposed to cold,» said one of the study's authors, Philip A. Kern, MD, of the University of Kentucky School of Medicine in Lexington, KY. «Browning fat tissue would be an excellent defense against obesity.

The analysis revealed belly fat tissue biopsied in the winter had a higher level of two genetic markers for beige fat, compared to the samples taken in the summertime.

In research that has implications for diabetes and other metabolic diseases, an international study based at UT Southwestern Medical Center found that the protein connexin 43 (Cx43) forms cell - to - cell communication channels on the surface of emerging beige fat cells that amplify the signals from those few nerve fibers.

But cold is «the only stimulus we know that can increase beige fat mass or brown fat mass,» says Ajay Chawla, a physiologist at the University of California (UC), San Francisco.

When they exposed these mice to the cold, the animals developed far fewer beige fat cells than did normal animals, suggesting that macrophages were key to browning of white fat.

The same effect occurred in preliminary studies of people, where the browning — which creates a tissue known as beige fat — helps generate heat and burn calories.

The 2015 study, done at Washington State University, reported that mice that were fed a diet containing 0.1 percent resveratrol were able to convert their excess white body fat (the type that can lead to health risks) into metabolism - revving beige fat.

Activation of sympathetic nervous system also resulted in the formation of beige fat cells from white fat cells.

Our findings suggest that activating Cx43 may cause the formation of more beige fat and thus increase the anti-diabetic effects seen in this study,» Dr. Scherer added.

Exercise, however, seems to transform white fat into beige fat — a middle ground between white and brown.

In mice, the hormone helps convert white (or «bad») fat into more useful energy - burning beige fat, molecular biologist Keertik Fulzele of Boston University and colleagues reported in the February Journal of Bone and Mineral Research.

Levels of a protein that helps the body produce heat, and that's expressed in beige fat, soared 15-fold, and the animals» energy expenditure increased by 15 % to 20 % — just as if they were sitting in a chilly cage.

The scientists also found new genetic markers of this beige fat.

But until now, it had not been known whether this fat is the so - called classical brown fat of the type that babies are born with, or beige fat, which is found within white fat and has the ability to convert, or recruit, white fat into brown fat in response to cold or other stresses.

The study, recently published in Cell Metabolism, also found that beige fat, unlike the better - known white and brown fat, has interesting anti-diabetic effects on blood sugar metabolism that seem independent of temperature regulation.

When rodents are exposed to cold temperatures, they can convert white fat deposits to beige fat.

The analysis checked the tissue samples for specific genetic markers found in brown or beige fat.

Second, beige fat may be more interesting from an anti-diabetic, metabolic standpoint — a finding with significant clinical relevance — than from a body temperature, warming standpoint,» explained Dr. Scherer, who holds the Gifford O. Touchstone, Jr. and Randolph G. Touchstone Distinguished Chair in Diabetes Research.

«Our findings indicate inflammation can hinder the conversion of white to beige fat,» Kern said.

Exposure to cold temperatures can convert white fat tissue from the thighs and belly to beige fat that burns calories for heat, but this biological response is hampered in obese people, according to a new study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism.

To study the metabolic effects of beige fat, the researchers compared mice with Cx43 that are able to make beige fat normally to mice unable to make Cx43, meaning their white fat seldom got the message to change to beige in response to cold.

Beige fat cells have the potential to turn into energy - burning brown fat cells when activated by exercise.

«Moreover, this study highlights mitochondrial fission — or the splitting of mitochondria — as a pivotal mechanism by which bile acids turn white fat into beige fat,» adds Alessia Perino, co-first author.

«Melatonin helps control weight gain as it stimulates the appearance of «beige fat» that can burn calories instead of storing them, study suggests.»

The fact is that one of the key differences between «beige fat», which appears when administering melatonin, and «white fat», is that «beige fat» cell mitochondria express levels of UCP1 protein, responsible for burning calories and generating heat.

In view of their most recent results, it seems the key lies in the fact that chronic melatonin consumption not only induces the appearance of «beige fat» in obese diabetic rats, but also increases its presence in thin animals used as a control group.

«Beige fat» cells are found in scattered lentil - sized deposits beneath the inguinal skin in obese diabetic Zucker rats.

White adipose tissue stores calories leading to weight gain whereas «beige fat» (also known as «good or thinning fat») helps regulate body weight control, hence its metabolic benefits.

In a major breakthrough earlier this year, Kajimura's group showed for the first time that brown fat in adult humans consists primarily of so - called «beige fat,» which can transform from white to brown in cold conditions.

Spanish scientists have discovered that melatonin consumption helps control weight gain because it stimulates the appearance of «beige fat», a type of fat cell that burns calories in vivo instead of storing them.

«This mechanism for basically inducing these brown or beige fat cells... wasn't previously recognized,» says Patrick Seale, a molecular metabolism expert at the University of Pennsylvania.

But could giving IL - 4 to healthy mice, housed in temperate conditions, create more beige fat?

The same applies to the beige fat cells on which the researchers are pinning their hopes.

Those epigenetic changes transform white fat cells into what researchers refer to as «beige fat cells,» which perform thermogenesis like brown fat cells.

Although transforming white fat cells into beige fat cells and increasing thermogenesis is naturally a stress response to chronic cold exposure involving adrenaline, researchers report that the same white - to - beige fat cell transition can be caused without adrenaline or cold stress.

PULLMAN, Wash. — Washington State University scientists have shown that berries, grapes and other fruits convert excess white fat into calorie - burning beige fat, providing new strategies for the prevention and treatment of obesity.

Another cell, called a beige fat cell, is an energy - burning cell that comes from the same precursor cell as white fat cells.