«This study provides evidence that there is
plasticity or compensation ability in the aging
brain that appears to be
beneficial, even in the face of beta - amyloid accumulation,» said study principal investigator Dr. William Jagust, a professor with joint appointments at UC Berkeley's Helen Wills Neuroscience Institute, the School of Public Health and Lawrence Berkeley National Laboratory.
We have previously shown ex-vivo its
beneficial effect on synaptic transmission and
plasticity in a mouse model of the OPHN1 loss of function.Here, we report that chronic treatment in adult mouse with Fasudil, is able to counteract vertical and horizontal hyperactivities, restores recognition memory and limits the
brain ventricular dilatation observed in Ophn1 - / y However, deficits in working and spatial memories are partially or not rescued by the treatment.