Sentences with phrase «benefit subsets of patients»

He adds, «This study was actually a pilot project for a much larger effort within the Center for Molecular Therapeutics to map responses against drug combinations across hundreds of cancer cell lines, not just melanoma, and look for novel combinations that will benefit subsets of patients regardless of the particular type of tumor they have.

«We now have a better idea of how NSAID use may benefit a subset of patients diagnosed with colorectal cancer,» said Xinwei Hua, the study's first author and an epidemiologist at Fred Hutch.

Not exact matches

In a matched cohort of 1,706 patients in each arm, the researchers still found an overall survival benefit with BCT over mastectomy in the HR positive subset but not in the HR negative subset.

«The good news is that we discovered that a subset of patients who had both high tumor mutation burden and high PDL - 1 positive status did experience a significant benefit from immunotherapy,» says Carbone.

He benefits from a medication that targets the underlying cause of the disease for a small subset of cystic fibrosis patients.»

The study was not powered to detect this improvement, but Kelbaek said he and his team would now look carefully for possible «hypothesis - generating» findings in subsets of patients — both those who might have benefitted from the deferred - treatment strategy and, equally important, those in whom this strategy might have worsened their condition.

«At the moment, Avastin is given to all colon cancer patients but only a subset of patients benefits from it,» John says.

Within the subset of 23 patients that were in the higher dose cohorts and would qualify for the Toca 5 trial, patients had a median survival of 14.4 months and 43.5 % (10/23) of patients had clinical benefit (5 complete responses and 5 stable disease patients).

However, subset analyses of phase III trials suggest that patients with EGFR mutation - positive NSCLCs do not benefit from immunotherapy compared with docetaxel.

Modeling mRNA expression heterogeneity in tumors through bimodal profiles is a novel powerful approach with the potential to uncover therapeutic targets that benefit subsets of cancer patients.

«There might be a subset of COPD patients who might benefit from statin use who don't need a statin for cardiovascular reasons, but the heart and lungs are intertwined, and it's hard to tease out someone with COPD who doesn't have risk factors for cardiovascular disease,» Horovitz said.

Any form of swaddling would benefit a very large subset of patients.