Scientists at the Institute of Human Genetics at Newcastle University in Britain said
the benefits of aspirin were only seen after several years.
Yet few among us today have not benefited from such trials, whether the lessons were positive (e.g.,
the benefits of an aspirin a day to reduce heart - attack risk) or negative (e.g., the increased risk of cancer associated with long - term hormone - replacement therapy).
Further studies would help to confirm the findings, further elucidate the risks and
benefits of aspirin use in this patient population, and potentially inform specific guidelines for treatment of patients with diabetes and heart failure.
«Medical providers must consider whether the potential for bleeding outweighing the potential
benefits of aspirin therapy in patients who don't yet meet the guidelines for prescribing aspirin therapy,» said the study's lead and senior author, Ravi S. Hira, M.D. and Salim S. Virani, M.D., Ph.D., of the Baylor College of Medicine in Houston.
«One of the treatments that we used was aspirin, but we know from other trials that the long - term
benefit of aspirin in preventing stroke is relatively modest.
They found that almost all of
the benefit of aspirin in reducing the risk of another stroke was in the first few weeks, and that aspirin also reduced the severity of these early strokes.
After a mini-stroke, almost all of
the benefit of aspirin in reducing the risk of another stroke was found to be in the first few weeks, and researchers also found that aspirin also likely reduced the severity of these early strokes.
Not exact matches
A handful
of doctors claim that
aspirin's
benefits stem from the fact that it is a vital micronutrient which should be reclassified as a vitamin (New Scientist, 7 February 2004, p 36).
«The
benefits seen in COMPASS are on the top
of other effective therapies such as statins,
aspirin, ACE inhibitors and beta blockers, and so their collective impact is substantial.
«Immediate
aspirin after mini-stroke substantially reduces risk
of major stroke:
Benefits of taking
aspirin immediately after minor strokes have been underestimated.»
Although
aspirin reduces the risk
of major cardiovascular events by 19 per cent, a more effective antithrombotic strategy could have major
benefits for the large population
of patients with stable cardiovascular disease.
The results come during a time when studies investigating
aspirin's anti-cancer effects have found evidence to support its
benefit, beyond staving off cardiovascular disease or, in oncology, reducing the risk
of colorectal cancer.
«Understanding how people respond to
aspirin is key in terms
of knowing who will
benefit from it.»
Adding the antiplatelet drug ticagrelor to
aspirin as long - term therapy after a heart attack significantly reduced the rate
of subsequent death from cardiovascular causes, heart attack or stroke, with the
benefit appearing to accrue for nearly three years, according to a study presented at the American College
of Cardiology's 64th Annual Scientific Session.
Small peptides have the
benefits of small molecule drugs, like
aspirin, and large antibody therapies, like rituximab, with fewer drawbacks.
The study further suggests that NSAIDs such as
aspirin, ibuprofen and naproxen have a particularly advantageous effect when taken after diagnosis by colorectal, or CRC, patients without tumor mutation in the KRAS gene (KRAS wild - type tumors): The study shows that NSAID use by this group is associated with a survival
benefit of 40 percent.
Objective To identify common genetic markers that may confer differential
benefit from
aspirin or NSAID chemoprevention, we tested gene × environment interactions between regular use
of aspirin and / or NSAIDs and single - nucleotide polymorphisms (SNPs) in relation to risk
of colorectal cancer.
Hence, understanding the interrelationship between genetic markers and use
of aspirin and NSAIDs, also known as gene × environment interactions, can help to identify population subgroups defined by genetic background that may preferentially
benefit from chemopreventive use
of these agents and offer novel insights into underlying mechanisms
of carcinogenesis.
Previous genetic studies have examined the association
of aspirin, NSAIDs, or both with colorectal cancer according to a limited number
of candidate genes or pathways.6 - 10 Thus, to comprehensively identify common genetic markers that characterize individuals who may obtain differential
benefit from
aspirin and NSAIDs, we conducted a discovery - based, genome - wide analysis
of gene × environment interactions between regular use
of aspirin, NSAIDs, or both and single - nucleotide polymorphisms (SNPs) in relation to risk
of colorectal cancer.
Based on these rates, the research team weighed the likelihood
of an individual to
benefit from
aspirin therapy (the potential
of the
aspirin to prevent a heart attack) against the likelihood
of harm (the potential for the
aspirin to cause major bleeding).
Routine use
of aspirin, NSAIDs, or both for chemoprevention
of cancer is not currently recommended because
of uncertainty about risk -
benefit profile.
But now we're zeroing in on biological markers that will tell us who will
benefit from taking
aspirin, as well as trying to find the sweet spot
of how much
aspirin and for how long.
This large study with long - term follow - up was one
of the first to examine the potential
benefits of different doses and durations
of aspirin use.
He also noted that earlier this year, the influential U.S. Preventive Services Task Force «suggested that certain populations at average risk
of colon cancer may
benefit from taking low - dose
aspirin.»
«This article synthesizes what many people in the field are beginning to feel: The risks
of daily
aspirin therapy exceeds the
benefits in people who have not had a heart attack,» says Steven E. Nissen, MD, the chairman
of cardiovascular medicine at the Cleveland Clinic, in Ohio.
«Because
of some recent studies suggesting that the
benefit is not very large, and because
aspirin can also have risks (intestinal bleeding or hemorrhagic stroke), the January 2010 recommendations will recommend it mostly for higher - risk people than was the case in the past, when it was recommended for people with more moderate levels
of risk and above,» says M. Sue Kirkman, MD, the vice president
of clinical affairs for the ADA.
This
benefit of taking
aspirin was seen after the researchers adjusted for other factors such as sex, age, cancer state, type
of treatment, and other health conditions.
The
benefits for GI cancers seemed to manifest even with a lower dose
of aspirin, starting with half a standard
aspirin tablet weekly.
Still, for those at risk for heart disease, the
benefits of daily
aspirin almost always outweigh the potential risks, says Thomas Lee, MD, professor
of medicine at Harvard Medical School and editor in chief
of the Harvard Heart Letter.
In your opinion, would ingesting
aspirin during such a short fast be
of any
benefit in prompting AMPK?
At the low doses used to protect the heart,
aspirin has only a small effect on inflammation; its heart
benefit comes primarily from its ability to reduce the risk
of blood clots.
Aspirin being formulated originally from Frederick Bayer would drink white willow nightly and wanted to offer the
benefits of white willow to general public.
So, eating a plant - based diet, one might be able to get some
of the
benefits of taking
aspirin, without some
of the risks.
In adults age 70 and above there is insufficient data to assess the
benefit versus the harm
of a preventive daily
aspirin.
There is no evidence that non-steroidal anti-inflammatory drugs, such as
aspirin, are
of any
benefit.
According to the American Heartworm Society, use
of aspirin in dogs infected with heartworms is no longer recommended due to a lack
of evidence
of clinical
benefit and may be contraindicated.
Researchers at Oxford University noted that while taking
aspirin carries a small risk
of stomach bleeding, that risk was beginning to be «drowned out» by its
benefits in reducing the risk
of cancer and the risk
of heart attacks.