From accelerating the identification and validation of novel therapeutic targets, to creating
better animal models of human diseases in a shorter time frame, to reducing the number of failed products, Crispr looks set to shave millions off R&D costs and boost drug discovery, she says.
The finding, by researchers at the University of Illinois at Chicago College of Medicine, was reported July 16 at the Alzheimer's Association International Conference in Copenhagen by Mary Jo LaDu, who in 2012 developed a transgenic mouse that is now regarded as
the best animal model of the human disease.
Not exact matches
Schmidt says, «These people can test compounds or antibodies in
well - defined
animal models that are representative
of a
human disease.»
No, studies using
animal models of human disease as
well as «humanized mice» are expressly forbidden.
Investigating mouse
models for biological for research The congress aims to promote the International Mouse Phenotyping Consortium (IMPC) mouse lines, importance
of mouse phenotyping & clinical and drug discovery collaboration, to present progresses performed by IMPC with regards CRISPR editing genome, rare
diseases, microbiota and ageing pipeline, as
well as illustration
of examples
of scientific projects about «
Animal models for
human diseases» and recent developments in mouse
models phenotyping imaging.
Now this latter element, it turns out that we have a real opportunity because as Dave Calkins and others have now demonstrated very beautifully in
animal models, and we even have very
good data now in
humans; in glaucoma there's an injury that happens first, and it's the death or loss
of the cell that happens later in the
disease.
The congress aims to promote the International Mouse Phenotyping Consortium (IMPC) mouse lines, importance
of mouse phenotyping & clinical and drug discovery collaboration, to present progresses performed by IMPC with regards CRISPR editing genome, rare
diseases, microbiota and ageing pipeline, as
well as illustration
of examples
of scientific projects about «
Animal models for
human diseases» and recent developments in mouse
models phenotyping imaging.
Furthermore, the heterozygous knock in mouse serves as a
better animal model of the
human disorder, as compared to the homozygous mouse, given that Huntington
disease homozygosity is very rare in
humans.
Animal models are necessary to develop improved diagnostics and therapeutics, as
well as understanding the basic pathophysiology
of common
human laryngeal
diseases.
The emphasis is on developing intellectual abilities and research skills through investigations
of infectious
diseases of food - producing, companion, and aquatic
animals, as
well as
animal models for
human disease.
This
model is important in that it addresses a significant
disease and can
model how to identify and change
human variables to
better improve other aspects
of the complex relationships that we have with domestic and companion
animals.