Sentences with phrase «best model mouse»
Any scientist would also be quick to point out that even the best model mouse does not actually have autism, which is a uniquely human condition.
https://www.scientificamerican.com/ Not exact matches
Sue, who works at Memorial University, Newfoundland, Canada, first looked at studies with mice, which he suggests are «good models for human physiology.»
While our work has used mouse models because we can study the process in detail this way, we do know that milk cells cross into human babies as well.»
To better understand their findings, the team examined the animal model for APS1 (i.e. mice with the same genetic defect as human patients with the syndrome) and found that male mice spontaneously developed an inflammatory disease in their prostate glands — a so - called prostatitis — and reacted to transglutaminase 4.
For researchers using mouse models to study a variety of cancers, including lymphoma, melanoma, breast, and prostate cancers as well as autoimmune and infectious diseases, the panel facilitates a highly sensitive and high - throughput investigation of biomarkers associated with disease progression.
But should scientists ditch their furry model altogether, or can they simply build a better mouse?
A recent study showed that mice were better models when they were exposed to common human viruses.
To study this question, the researchers focused on the grey mouse lemur, a small primate whose lifespan (around twelves years) makes it a very good model for the study of aging.
The study results were found using mouse embryonic stem cells, which are good cell models for the study of processes seen in human stem cells.
Dr Luis Pedro Coelho, commented: «These findings suggest that dogs could be a better model for nutrition studies than pigs or mice and we could potentially use data from dogs to study the impact of diet on gut microbiota in humans, and humans could be a good model to study the nutrition of dogs.
«Gene therapy restores hearing in deaf mice, down to a whisper: Improved delivery vector better penetrates the inner ear, also restores balance in a mouse model of Usher syndrome.»
«A happy mouse is a better model.»
While mouse models have traditionally been used in studying the genetic disorder, Deng said the animal model is inadequate because the human brain is more complicated, and much of that complexity arises from astroglia cells, the star - shaped cells that play an important role in the physical structure of the brain as well as in the transmission of nerve impulses.
To study the relationship between autism and subplate neuron development in mice, Kanold, Nagode and their collaborators began with a well - established mouse model of autism.
Herzberg said his stories dealt «with obviousness that is not obvious... the stethoscope as the eternal symbol of doctors, mice as our best animal model, eels as simple, almost boring, river fishes.
Using a mouse model of HSV - 1 as well as autopsied samples of human adult and fetal tissues, investigators from Dartmouth College's Geisel School of Medicine found that antibodies against HSV - 1 produced by adult women or female mice could travel to the nervous systems of their yet unborn babies, preventing the development and spread of infection during birth.
«For example, cancer research is heavily reliant on mouse models, and as a result we've become very good at curing mice, but that hasn't translated very well to humans.
She and her colleagues will be exploring the role of YY1 further, using clinical samples as well as mouse models, to look at the protein in diseases like lupus to deepen their understanding of how autoimmunity could result from the «escape» of immune genes from X chromosome inactivation.
This anxious behavior mirrored that of CdLS patients, while autopsied brain tissue from individuals with CdLS showed symptoms of disease that matched those of the experimental mice suggesting that they were a good animal model.
Desgrosellier said the team will follow up with mouse models containing tumor fragments from patients to better reflect the diversity of cell types present in human disease.
To better determine the role of specific chemoattractants in type III hypersensitivity, lead author Yoshishige Miyabe, MD, PhD, a research fellow in Luster's lab, used multiphoton intravital microscopy — an imaging technology pioneered for studies of immune cell movements in living animals by CIID investigator and co-author Thorsten Mempel, MD, PhD — to follow in real time the development of IC - induced arthritis in a mouse model of rheumatoid arthritis.
«This research project is a prime example of how mouse models can help us to better understand cancer diseases in human beings,» says Sabine Harlander.
The new mouse model will make it possible to develop better therapies for renal cancer.
The researchers were studying a well - established mouse model that forms a significant number of CCMs following the injection of a drug to induce gene deletion.
The mice described in the current report were developed for testing of drug and vaccine candidates and may not be good models for human transmission, said Weaver.
Efforts aimed at finding better drug regimens would therefore greatly benefit from a mouse model with an intrinsic marker that can indicate different stages of pancreatic tumor formation leading to cancer and reflect the effects exerted by novel drug candidates.
They directly injected into the cerebrospinal fluid of a mouse model of Alzheimer's — adult animals in which plaques were well established — viral vectors carrying genes for one of the three APOE variants or a control protein.
I work in hearing research, and I am now working on genes that are linked to blood (platelet) disorders as well as with mouse models expressing mutant steroid (androgen) receptor genes.
He also believes the technique will work reasonably well for studying the structure and function of proteins in most other model organisms, including laboratory mice.
Next - generation NSG models that support human myeloid cell proliferation, such as the NSG - SGM3 mouse, can now provide in vivo conditions that better mimic the natural tumor environment.
«Building a better mouse model to understand pancreatic cancer.»
With the help of various mouse models for pancreatic cancer, they have succeeded in elucidating the molecular pathways of tumor development in detail and have gained a better understanding of how various characteristics of the disease arise.
As they develop human clinical trials, Wargo and colleagues also are conducting lab and mouse model research to better understand the mechanisms that connect bacteria and the immune system.
To better understand what metabolic changes occur in place of fatty acid - burning, Kelly's team studied well established mouse models of the early and late stages of heart failure.
National Institutes of Health (NIH) scientists have developed a mouse model to study Zika virus transmitted sexually from males to females, as well as vertically from a pregnant female to her fetus.
Mice given alcohol just after birth are a good model for measuring the impact on human fetal development because the brains of mice pups achieve developmental milestones after birth that are comparable to those in other mammals, including humMice given alcohol just after birth are a good model for measuring the impact on human fetal development because the brains of mice pups achieve developmental milestones after birth that are comparable to those in other mammals, including hummice pups achieve developmental milestones after birth that are comparable to those in other mammals, including humans.
Mice have proven to be a particularly good model for studies relevant to humans, Magnusson said, on such topics as aging, spatial memory, obesity and other issues.
Using all the existing data that was available, Andrechek, along with MSU doctoral student Daniel Hollern, analyzed 1,172 mouse mammary tumor samples from 26 different preclinical models and was able to compile one of the largest databases to show which strains of mice were best suited to study a particular type of human breast cancer.
To build on the work, Anguera's team is performing additional studies using primary samples from lupus patients as well as samples from a mouse model of lupus.
Ward's lab team took skin tissue samples from her well - established psoriasis transgenic mouse model, called the KC - Tie2 mouse, and compared it to skin tissue samples of normal mice.
The mice are particularly good models of estrogen receptor - positive tumors (so named because they are fueled by estrogen) that have become resistant to the drugs used to treat them.
The lab's resident mouse whisperer, newly minted neuroscientist Kimberly Maguschak, will run some tests she uses in her quest to build a better mouse model of anxiety and depression.
He says, however, because they are small and easy to keep in captivity — unlike wild mice, which are notoriously difficult to maintain in cages — wall lizards would make a good model species for experiments designed to determine the effects of toxins on mortality, reproduction and growth.
The solution, however, isn't simply finding better mouse models; it also involves redefining diseases to include the physiological underpinnings that mice illuminate so well.
«What we did in this paper is engineer our sensor to be about 15 times better than a previous version, and then compared it against a blood biomarker in a mouse model of ovarian cancer to show that we could beat it,» says Sangeeta Bhatia, the John and Dorothy Wilson Professor of Health Sciences and Technology and Electrical Engineering and Computer Science, a member of MIT's Koch Institute for Integrative Cancer Research and Institute for Medical Engineering and Science, and the senior author of the study.
«We have known that the mouse was mostly a good model for humans.
Recently, many scientists came to suspect that a protein called NF - κB, a master regulator of infection and inflammation, was at work; in 1996, several groups had found that it also inhibited cell death, which can lead to tumor formation.To find out whether suspicions about NF - κB were well - founded, molecular biologist Michael Karin of the University of California, San Diego, and his colleagues turned to a mouse model of colitis.
«Mice are a good model for understanding how teeth are made, but not a good model for understanding the finer details of how teeth evolved,» she said.
The new test allowed them to observe how interactions between synapses and astrocytes change over time, as well as during various diseases, in mouse models.
The finding, by researchers at the University of Illinois at Chicago College of Medicine, was reported July 16 at the Alzheimer's Association International Conference in Copenhagen by Mary Jo LaDu, who in 2012 developed a transgenic mouse that is now regarded as the best animal model of the human disease.