Sentences with phrase «best possibility of changing»

«Phase II studies are given to the most successful Phase I fellows, whose ideas have the best possibility of changing the possible,» said Derleth.

Not exact matches

Important factors that could cause actual results to differ materially from those reflected in such forward - looking statements and that should be considered in evaluating our outlook include, but are not limited to, the following: 1) our ability to continue to grow our business and execute our growth strategy, including the timing, execution, and profitability of new and maturing programs; 2) our ability to perform our obligations under our new and maturing commercial, business aircraft, and military development programs, and the related recurring production; 3) our ability to accurately estimate and manage performance, cost, and revenue under our contracts, including our ability to achieve certain cost reductions with respect to the B787 program; 4) margin pressures and the potential for additional forward losses on new and maturing programs; 5) our ability to accommodate, and the cost of accommodating, announced increases in the build rates of certain aircraft; 6) the effect on aircraft demand and build rates of changing customer preferences for business aircraft, including the effect of global economic conditions on the business aircraft market and expanding conflicts or political unrest in the Middle East or Asia; 7) customer cancellations or deferrals as a result of global economic uncertainty or otherwise; 8) the effect of economic conditions in the industries and markets in which we operate in the U.S. and globally and any changes therein, including fluctuations in foreign currency exchange rates; 9) the success and timely execution of key milestones such as the receipt of necessary regulatory approvals, including our ability to obtain in a timely fashion any required regulatory or other third party approvals for the consummation of our announced acquisition of Asco, and customer adherence to their announced schedules; 10) our ability to successfully negotiate, or re-negotiate, future pricing under our supply agreements with Boeing and our other customers; 11) our ability to enter into profitable supply arrangements with additional customers; 12) the ability of all parties to satisfy their performance requirements under existing supply contracts with our two major customers, Boeing and Airbus, and other customers, and the risk of nonpayment by such customers; 13) any adverse impact on Boeing's and Airbus» production of aircraft resulting from cancellations, deferrals, or reduced orders by their customers or from labor disputes, domestic or international hostilities, or acts of terrorism; 14) any adverse impact on the demand for air travel or our operations from the outbreak of diseases or epidemic or pandemic outbreaks; 15) our ability to avoid or recover from cyber-based or other security attacks, information technology failures, or other disruptions; 16) returns on pension plan assets and the impact of future discount rate changes on pension obligations; 17) our ability to borrow additional funds or refinance debt, including our ability to obtain the debt to finance the purchase price for our announced acquisition of Asco on favorable terms or at all; 18) competition from commercial aerospace original equipment manufacturers and other aerostructures suppliers; 19) the effect of governmental laws, such as U.S. export control laws and U.S. and foreign anti-bribery laws such as the Foreign Corrupt Practices Act and the United Kingdom Bribery Act, and environmental laws and agency regulations, both in the U.S. and abroad; 20) the effect of changes in tax law, such as the effect of The Tax Cuts and Jobs Act (the «TCJA») that was enacted on December 22, 2017, and changes to the interpretations of or guidance related thereto, and the Company's ability to accurately calculate and estimate the effect of such changes; 21) any reduction in our credit ratings; 22) our dependence on our suppliers, as well as the cost and availability of raw materials and purchased components; 23) our ability to recruit and retain a critical mass of highly - skilled employees and our relationships with the unions representing many of our employees; 24) spending by the U.S. and other governments on defense; 25) the possibility that our cash flows and our credit facility may not be adequate for our additional capital needs or for payment of interest on, and principal of, our indebtedness; 26) our exposure under our revolving credit facility to higher interest payments should interest rates increase substantially; 27) the effectiveness of any interest rate hedging programs; 28) the effectiveness of our internal control over financial reporting; 29) the outcome or impact of ongoing or future litigation, claims, and regulatory actions; 30) exposure to potential product liability and warranty claims; 31) our ability to effectively assess, manage and integrate acquisitions that we pursue, including our ability to successfully integrate the Asco business and generate synergies and other cost savings; 32) our ability to consummate our announced acquisition of Asco in a timely matter while avoiding any unexpected costs, charges, expenses, adverse changes to business relationships and other business disruptions for ourselves and Asco as a result of the acquisition; 33) our ability to continue selling certain receivables through our supplier financing program; 34) the risks of doing business internationally, including fluctuations in foreign current exchange rates, impositions of tariffs or embargoes, compliance with foreign laws, and domestic and foreign government policies; and 35) our ability to complete the proposed accelerated stock repurchase plan, among other things.

One virus - particle doesn't change color, but as it procreates mutations in that process can make the resulting child - virus differ from the parent - virus, so that the child - virus is capable of infecting a human as well as the original host thereby opening the possibility for a new human disease.

Jeremy i was stumped to on this one as well so i asked the holy spirit to help me i looked at alot of different possibilitys commentarys really werent any help apart from the background.Thinking that Jesus was somehow implicated with satan in any way seemed to be a contradiction of who he was.The holy spirit revealed that to understand these types of passages we can fully trust that God is who he says he is he he does nt change his character or who he is.He is almighty holy trustworthy faithful and more.

God forgives the sinner not in the sense that the sinner's past is changed, not in the sense that the consequences of his sin (to himself and others including God) are obliterated and past evils are no longer evils, but in the sense that possibilities for good are ever present in spite of the evils.

On the other hand, Whitehead by no means precludes the possibility of drastic changes for the better taking place in the future.

This longer view displays far more radical changes and indicates the possibility of great advances as well as catastrophes.

Considering that mutations, to name one method of generating new DNA sequences, can be detrimental as well as beneficial and each to varying degrees of hurt or help, I seriously doubt that just the number of DNA changes would be such a measure, even if such a number could be known given possibility of overwrites and deletions.

TBH I think Arsenal would fare much better without Wenger all together, just have Steve Bould, at least the squad could play in their proper positions, with the possibility of incurring less injuries, and they should be able to adapt to changing situations better.

In the event that they are forced into a managerial change though, the report claims that Spalletti has emerged as a real possibility as with his contract running down in the Italian capital, he may well face an uncertain future of his own.

There is still a possibility that Wenger will renew his contract with the Gunners, but having slipped out of the top four and, in doing so, the title race — it could well be time for a change in North London.

If you read the decommitment tweets, which are very well - written, the decommits were obviously a result of staff changes — which is totally reasonable — and they leave open the possibility of coming back into the fold should new relationships be reestablished (these are 2019 recruits, after all).

Time for some brutal honesty... this team, as it stands, is in no better position to compete next season than they were 12 months ago, minus the fact that some fans have been easily snowed by the acquisition of Lacazette, the free transfer LB and the release of Sanogo... if you look at the facts carefully you will see a team that still has far more questions than answers... to better show what I mean by this statement I will briefly discuss the current state of affairs on a position - by - position basis... in goal we have 4 potential candidates, but in reality we have only 1 option with any real future and somehow he's the only one we have actively tried to get rid of for years because he and his father were a little too involved on social media and he got caught smoking (funny how people still defend Wiltshire under the same and far worse circumstances)... you would think we would want to keep any goaltender that Juventus had interest in, as they seem to have a pretty good history when it comes to that position... as far as the defenders on our current roster there are only a few individuals whom have the skill and / or youth worthy of our time and / or investment, as such we should get rid of anyone who doesn't meet those simple requirements, which means we should get rid of DeBouchy, Gibbs, Gabriel, Mertz and loan out Chambers to see if last seasons foray with Middlesborough was an anomaly or a prediction of things to come... some fans have lamented wildly about the return of Mertz to the starting lineup due to his FA Cup performance but these sort of pie in the sky meanderings are indicative of what's wrong with this club and it's wishy - washy fan - base... in addition to these moves the club should aggressively pursue the acquisition of dominant and mobile CB to stabilize an all too fragile defensive group that has self - destructed on numerous occasions over the past 5 seasons... moving forward and building on our need to re-establish our once dominant presence throughout the middle of the park we need to target a CDM then do whatever it takes to get that player into the fold without any of the usual nickel and diming we have become famous for (this kind of ruthless haggling has cost us numerous special players and certainly can't help make the player in question feel good about the way their future potential employer feels about them)... in order for us to become dominant again we need to be strong up the middle again from Goalkeeper to CB to DM to ACM to striker, like we did in our most glorious years before and during Wenger's reign... with this in mind, if we want Ozil to be that dominant attacking midfielder we can't keep leaving him exposed to constant ridicule about his lack of defensive prowess and provide him with the proper players in the final third... he was never a good defensive player in Real or with the German National squad and they certainly didn't suffer as a result of his presence on the pitch... as for the rest of the midfield the blame falls squarely in the hands of Wenger and Gazidis, the fact that Ramsey, Ox, Sanchez and even Ozil were allowed to regularly start when none of the aforementioned had more than a year left under contract is criminal for a club of this size and financial might... the fact that we could find money for Walcott and Xhaka, who weren't even guaranteed starters, means that our whole business model needs a complete overhaul... for me it's time to get rid of some serious deadweight, even if it means selling them below what you believe their market value is just to simply right this ship and change the stagnant culture that currently exists... this means saying goodbye to Wiltshire, Elneny, Carzola, Walcott and Ramsey... everyone, minus Elneny, have spent just as much time on the training table as on the field of play, which would be manageable if they weren't so inconsistent from a performance standpoint (excluding Carzola, who is like the recent version of Rosicky — too bad, both will be deeply missed)... in their places we need to bring in some proven performers with no history of injuries... up front, although I do like the possibilities that a player like Lacazette presents, the fact that we had to wait so many years to acquire some true quality at the striker position falls once again squarely at the feet of Wenger... this issue highlights the ultimate scam being perpetrated by this club since the arrival of Kroenke: pretend your a small market club when it comes to making purchases but milk your fans like a big market club when it comes to ticket prices and merchandising... I believe the reason why Wenger hasn't pursued someone of Henry's quality, minus a fairly inexpensive RVP, was that he knew that they would demand players of a similar ilk to be brought on board and that wasn't possible when the business model was that of a «selling» club... does it really make sense that we could only make a cheeky bid for Suarez, or that we couldn't get Higuain over the line when he was being offered up for half the price he eventually went to Juve for, or that we've only paid any interest to strikers who were clearly not going to press their current teams to let them go to Arsenal like Benzema or Cavani... just part of the facade that finally came crashing down when Sanchez finally called their bluff... the fact remains that no one wants to win more than Sanchez, including Wenger, and although I don't agree with everything that he has done off the field, I would much rather have Alexis front and center than a manager who has clearly bought into the Kroenke model in large part due to the fact that his enormous ego suggests that only he could accomplish great things without breaking the bank... unfortunately that isn't possible anymore as the game has changed quite dramatically in the last 15 years, which has left a largely complacent and complicit Wenger on the outside looking in... so don't blame those players who demanded more and were left wanting... don't blame those fans who have tried desperately to raise awareness for several years when cracks began to appear... place the blame at the feet of those who were well aware all along of the potential pitfalls of just such a plan but continued to follow it even when it was no longer a financial necessity, like it ever really was...

«It needs a culture change for them to look at IndyCar drivers as a possibility, and I hope there is because there are world - class drivers that are being wasted and could be doing even bigger things in the public eye in Formula One and doing better than some of the people already there.»

I also completely agree with you that that HHFKA was underfunded from the get - go, which makes serving healthier food that much harder for FSDs due to increased food costs and labor, as well as the possibility of decreased participation due to changes in the food.

It's full of possibilities of doing better, being better, changing for the better.

You can also include some travel lotion to smooth those tushies up after cleaning, as well as at least 2 receiving blankets in your bag to dry them up (or catch dribble, or milk, or vomit, or lay on top of your changing pad in a public bathroom changing table... the possibilities are endless).

In that regard, any ruling party that is powerful of it's own - i.e., has intrinsic power not derived from voters; a power to stick to ruling despite the changing desires of people - is antidemocratic; so a «democracy through strength» is a danger that might (not always, but a possibility) turn into a dictatorship; and a «democracy through weakness» which is unable to do so and needs to re-estabilish it's power (and right to exist) at every single elections is a preferrable system of governance that would pay more attention towards their people, and be better for the people (as opposed to their own nomenclature).

Visitors will see the change through new signs and flags in the area, Worrell said, with the possibility of two Little Caribbean archways going up, as well.

«Global warming and climate change... increase the renewal and wear rates of lubrication materials, as well as the possibility of track twisting and buckling,» said Kaewunruen in an earlier paper with Lei Wu, who is currently working on the Kuala Lumpur - Singapore High Speed Railway.

Saunders, a deputy assistant of Interior during the Clinton administration, said the sea level estimates are well within the realm of possibility, again referencing IPCC data and the state - funded California Climate Change Center.

A new study shows how the patterns of online communication change by implementing teacher leadership techniques, which opens possibilities for better online classroom design.

The study is important because it links diet to changes in the gut microbiota as well as bile acid profile, opening the possibility that probiotics and bile acid receptor agonists may be useful for the prevention and treatment of hepatic inflammation and progression into advanced liver diseases such as cancer.

To better anticipate the next sudden change, the committee recommends the creation of an early warning system and research to better understand the possibilities.

Such modifications in human beings raise the possibility that we are changing not merely a single individual but a host of future individuals as well, with potential for harm to occur to those individuals and perhaps to humanity as a whole.

None of the dietary changes that we propose have loss of lactation as a typical result, but it's always best to listen to your gut and not make any abrupt changes while breastfeeding, just to account for the very rare possibility that you do respond negatively.

When your crush is single, it seems like there are all sorts of possibilities, and once that relationship status changes on Facebook... well, it Which of the following are you doing — or are planning to do — to get your ex-girlfriend back?

When your crush is single, it seems like there are all sorts of possibilities, and once that relationship status changes on Facebook... well, it Whoever said that dating was fun obviously isn't dating in today's modern age.

When your crush is single, it seems like there are all sorts of possibilities, and once that relationship status changes on Facebook... well, it One in ten Americans have used an online dating site or mobile dating app; 66 % of them have gone on a date with someone they met through a dating site or app,

I really wish they make a sequel and they put a better competitive mp and fix the vehicules and also more variety of enemies and weapons and maybe the possibility to change to third person view so u can see ur own looks

Not only does it drastically recontextualise the world in which Infinity War will take place — radically changing the rules and possibilities of how battle with Thanos could play out, as well as the very nature of what «saving the world» means in a scenario where there are infinite different versions of that world — but there's also a good chance that the events of Doctor Strange will play directly into Infinity War's conclusion, and the lead - in to Avengers 4.

It's all in the character arc as Kingsley's Frank Falenczyk goes from darkly sarcastic, antisocial, and vodka - swilling to a man accepting of the possibility of change for the better.

I can do this I will get through this I will be okay I am capable of amazing things I am a good person I deserve to be happy I am stronger than I think I am amazing I can do anything I set my mind to I will keep going Do not give up Keep moving forward I can handle change with ease I am unique I believe in my abilities and skills I can face every situation with confidence There is always a solution to every problem I am responsible for how I respond to others I have the power to choose to let go of any emotion Any difficulty that comes my way is an opportunity to grow I am full of energy and joy I have the power to create change My possibilities are endless I am in charge of how I feel I choose happiness I can, I will I can make healthy choices

Hope in the Dark: Untold Histories, Wild Possibilities Hope in the Dark is a slim volume by Rebecca Solnit that is essential reading for anyone who aspires to do good in this world and needs a boost of hope that we can make positive political change.

Included in the PowerPoint: Macroeconomic Objectives (AS Level) a) Aggregate Demand (AD) and Aggregate Supply (AS) analysis - the shape and determinants of AD and AS curves; AD = C+I+G + (X-M)- the distinction between a movement along and a shift in AD and AS - the interaction of AD and AS and the determination of the level of output, prices and employment b) Inflation - the definition of inflation; degrees of inflation and the measurement of inflation; deflation and disinflation - the distinction between money values and real data - the cause of inflation (cost - push and demand - pull inflation)- the consequences of inflation c) Balance of payments - the components of the balance of payments accounts (using the IMF / OECD definition): current account; capital and financial account; balancing item - meaning of balance of payments equilibrium and disequilibrium - causes of balance of payments disequilibrium in each component of the accounts - consequences of balance of payments disequilibrium on domestic and external economy d) Exchange rates - definitions and measurement of exchange rates - nominal, real, trade - weighted exchange rates - the determination of exchange rates - floating, fixed, managed float - the factors underlying changes in exchange rates - the effects of changing exchange rates on the domestic and external economy using AD, Marshall - Lerner and J curve analysis - depreciation / appreciation - devaluation / revaluation e) The Terms of Trade - the measurement of the terms of trade - causes of the changes in the terms of trade - the impact of changes in the terms of trade f) Principles of Absolute and comparative advantage - the distinction between absolute and comparative advantage - free trade area, customs union, monetary union, full economic union - trade creation and trade diversion - the benefits of free trade, including the trading possibility curve g) Protectionism - the meaning of protectionism in the context of international trade - different methods of protection and their impact, for example, tariffs, import duties and quotas, export subsidies, embargoes, voluntary export restraints (VERs) and excessive administrative burdens («red tape»)- the arguments in favor of protectionism This PowerPoint is best used when using worksheets and activities to help reinforce the ideas talked about.

In startupers» world, presentations of the product can be life - changing; if you do it well, consider your business as full of promises, but if you fail, the possibility of success would be tending to zero.

We develop teachers and leaders who believe in the possibility of human change and growth, and who fight tirelessly for better outcomes for kids.

The language of ESSA presents both great opportunity and great danger, but because we think that the best organizing around community building emerges from vision, we are focused on the possibilities for positive change.

Set for UK sale from September, the lightly reworked CLS receives a number of subtle mid-life changes and an extended line of options, including Mercedes - Benz's latest Multibeam LED headlamps as well as new AMG Line Plus and Night packages that further extend the range of individualisation possibilities.

Due to reach North American dealers in November, the lightly reworked CLS receives a number of subtle midlife changes and an extended line of options, including Mercedes - Benz's latest Multibeam LED headlamps as well as new AMG Line Plus and Night packages that further extend the range of individualization possibilities.

What the industry hopefully will recognize is that change doesn't have to happen as long as authors are kept ignorant of the possibilities for better royalties and equal sales, a fact that AE reports are trying to remedy.

If you are an author, an awareness of the breadth of possibilities, as well as the importance of cover design, can only serve to help you as you shepherd your own literary creation through today's rapidly changing marketplace.

But it opens up a lot of new possibilities, and as the publishing world changes, it's good to be flexible like that.

Many COSI - indexed ARMs often have minimum payment change caps (usually, up to 7.5 % of minimum payment amount), as well as lifetime interest rate caps (usually, about 12 %) but no periodic interest rate caps creating the possibility for negative amortization.

With bad or good credit both, this is a possibility, but the rules may change a little and additional paperwork may be required in the case of those with bad credit.

The best approach is to call your card company and ask about the possibility of changes to your rates.

This could have been a negative change in the outlook on the company's operations, the possibility of a better return from another acquisition, an increase in the uncertainty surrounding the SEC investigation or an increase in the estimated settlement costs related to the SEC investigation.

Well, tech companies that adapt themselves well to changing environments will, but there is a possibility that many of them will be burdened by over-expectatiWell, tech companies that adapt themselves well to changing environments will, but there is a possibility that many of them will be burdened by over-expectatiwell to changing environments will, but there is a possibility that many of them will be burdened by over-expectations.

If the parameters of the game are changed to include the possibility of losing money, the 50 - 50 asset allocation does even better.

If your dog or cat's elimination behavior changes soon after the addition of a new medication there is a very good possibility that the drug is contributing to the diarrhea or other symptoms.