Sentences with phrase «beta amyloid»

These 3 actions can complement the capability of caffeine to suppress beta amyloid production within the brain.

The researchers correlated changes in the structural connectome with results from florbetapir positron emission tomography (PET) imaging, a technique that measures the amount of beta amyloid plaque in the brain.

Rockefeller University researchers have used a recently - developed imaging technique that makes tissue transparent to visualize brain tissue from deceased patients with Alzheimer's disease, exposing nonrandom, higher - order structures of beta amyloid plaques — sticky clumps of a toxic protein typically found in the brains of people with Alzheimer's.

In one study, curcumin inhibited the accumulation of destructive beta amyloid protein in the brain — the «tangles» that are the hallmark of cognitive decline.

One of the main ingredients in these plaques, a peptide called beta amyloid, is created when enzymes cut up a protein called APP.

Multiple genes on chromosome 21 are associated with individual differences in plasma levels of beta amyloid peptides in adults with Down syndrome

This idea of targeting beta amyloid deposits in the brain to clear them out is known as the «amyloid hypothesis.»

As beta amyloid proteins intertwine, they form tangled clumps that block the passage of signals from cell to cell.

They suggest that nicastrin and presenilin - 1 are members of a large complex they call a secretosome in which many proteins collaborate to make beta amyloid.

And more direct evidence for its role in making plaques is the fact that cells produced more beta amyloid if they contained certain mutated forms of nicastrin, the researchers report in the 7 September issue of Nature.

An illustration of how swapping an amino acid in beta amyloid precursor proteins results in longer and shorter strands

One approach companies are trying is to target certain beta amyloid proteins, which accumulate in the brain of people who have Alzheimer's.

The test, which measures beta amyloid plaque levels in cerebrospinal fluid, successfully diagnosed 15 Alzheimer's patients and wasn't tripped up by 19 people with other neurological diseases.

Previous efforts at early detection have focused on beta amyloid, a protein found in abnormally high amounts in the brains of people with Alzheimer's disease.

In that study, it was determined that suppressing a plasma - based protein called Factor XII, which is released as part of a flood on enzymes that occur when beta amyloids are present, could improve cognitive function in mice with the disease.

Bateman says those findings have implications for doctors using beta amyloid measurements to study Alzheimer's.

If you turn off the spigot and stop the development of new beta amyloid, you halt the disease.

Mark Dell» Acqua, Ph.D., CU School of Medicine: Study the role of calcium signaling in inhibition of synapse formation by beta amyloid plaque in Down syndrome (A-beta is the main component in plaques of Alzheimer's disease patients)

While this finding doesn't speak to the memory loss element, other finding support the idea that reduction in beta amyloid comes with direct (and positive) impact on memory retreival and formation.

Beta amyloid deposition in the atrophic form of general paresis.

It has been shown to lower beta amyloid production — a plaque that scientists have linked to brain destruction associated with Alzheimer's disease.

One of the waste products cleared during sleep is beta amyloid so Alzheimer's may just be a buildup of waste that hasn't been cleared over time.

In an article published in a 2007 issue of the «International Journal of Molecular Medicine,» researchers reported that the fructus lycii extract effectively neutralized several individual strains of beta amyloid peptides.

In a 2012 paper, Nedergaard and her colleagues announced the discovery of a waste - disposal system in the brain, in which toxic metabolites such as beta amyloid — associated with Alzheimer's and other neurodegenerative diseases — are flushed out by cerebrospinal fluid with the help of support cells called glia.

The more often we don't get a good night's sleep, the more beta amyloid and tau proteins build up in our brains.

Other promising therapies targeting beta amyloid are Myriad Genetics's drug Flurizan, in phase III, and Elan's vaccine AAB - 001, in phase II, says Leon Thal at the University of California, San Diego.

The other research presented at the symposium showed that a pure maple syrup extract prevented the fibrillation (tangling) of beta amyloid proteins and exerted neuroprotective effects in rodent's microglial brain cells.

The team conducted laboratory studies in which an extract containing fructus lycii polysaccharides was tested for its effectiveness against a variety of beta amyloid peptides, which are neurotoxins that have been implicated in the cause of Alzheimer's.

For one, it would give them three specific biological markers to hone in on: The buildup of beta amyloid and tau proteins, which cause brain plaques associated with Alzheimer's, and brain nerve cell death.

But for reasons that are yet unknown, when Alzheimer's develops, this protein divides improperly and creates a form called beta amyloid, which is toxic to neurons in the brain.

After conducting experiments with a newly developed strain of mice that are good surrogates for Alzheimer's, they found that a gene called ADAM10 makes an enzyme called alpha secretase, which prevents the formation of beta amyloid.

«These tangles of beta amyloid are known to be the problem in Alzheimer's,» says Daniell.

Several factors have been implicated in Alzheimer's, including the build - up of an abnormal protein called beta amyloid, fibrous tangles in the brain involving abnormal forms of a protein called tau, and — most recently — an association between the disease and a gene called ApoE.

The scientists found heightened levels of the two abnormal proteins — hyperphosphorylated tau and beta amyloid — in the brains of young urbanites with lifetime exposures to fine - particulate - matter pollution (PM2.5).

«If you prevent the buildup of beta amyloid, do you change the course of the disease?

A sampling of spinal fluid from healthy adults can detect an abnormal level of beta amyloid, indicative of Alzheimer's, Spreng said.

Plaques are the build up of sticky proteins called beta amyloid, and tangles are twisted strands of a protein called tau.

This also includes the potentially disease - causing proteins that collect in the cells of patients with neurodegenerative disorders — for example, beta amyloids that agglomerate to form long fibrils in the nerve cells of Alzheimer's patients.

Some of the cellular scissors that snip out beta amyloid are a group of enzymes called the presenilins (see Science, 22 October 1999, p. 650), but scientists know the presenilins have help.

Though it's clear that nicastrin is part of the machine that makes the beta amyloid peptide, he says, it's not clear what it does.

Amyloids are proteins that can build up in the brain, and beta amyloid is one of the hallmark features of Alzheimer's that can be detected in living brains.

The researchers found that levels of the beta amyloid protein in spinal fluid increased during waking hours and decreased during sleep.

Beta amyloid is a fragment of a protein snipped from another protein called amyloid precursor protein (APP).

Beta amyloid and hyperphosphorylated tau deposits in the pancreas in type 2 diabetes.

Evidence points to beta amyloid (Aβ) peptide accumulation as a culprit in preclinical Alzheimer's disease.

Despite decades of failures in Alzheimer's drug development, scientific attention continues to focus on drugs that «attack» a molecular compound called beta amyloid, with the goal of curing the disease.