Sentences with phrase «beta cell activity»
The team found an estimated 5,000 such cells, some of which were isolated and tested for their ability to restore beta cell activity.
https://www.scientificamerican.com/ Not exact matches
«Because brain cells release amyloid beta during activity, we think if the brain cells can't rest the way they're supposed to and get that deep sleep, they produce a relative excess of amyloid,» Dr. Yo - El Ju of Washington University, an author of that study, told Reuters.
However, tumors produce high amounts of a protein called Transforming Growth Factor - Beta (TGF - β) that suppresses the activity of NK cells.
Using single - cell RNA sequencing, the team was able to profile molecular features and metabolic activity of individual beta cells to determine how dividing beta cells differ from non-dividing cells.
«Under no circumstances should it be concluded from our work that consumption of marijuana can be a way to cure diabetes,» Prof. Dobrzyn warns and explains: «The concentration of glucose in the blood is determined by the balance between the activities of alpha and beta cells of the pancreas and insulin target tissues such as skeletal muscle and adipose tissue.
Using electrophysiological methods to measure electrical currents through cell membranes, the research group at the Institute for Physiology and Pharmacology, led by Marjan Slak Rupnik, showed that dextromethorphan extends the periods of electrical activity in beta cells.
More recently, the membrane receptor GARP was shown to bind to TGF - beta on regulatory T cells and platelets to modulate their activity.
TGF - beta 1 plays an important role in the mechanism of CD4 + CD25 + regulatory T cell activity in both humans and mice.
Clinical research activities are focused on the implementation of experimental protocols based on gene or cell therapy for the treatment of genetic blood disorders such as ADA - SCID, Wiskott - Aldrich Syndrome, Metachromatic Leukodystrophy, Beta - thalassemia, Chronic granulomatous disease, Mucopolysaccharidosis Type I (Hurler).
In their terminally nonproliferative state both p21 + / + and p21 - / - cultures were positive for the senescence - associated beta - galactosidase (SA - beta - gal) activity; in contrast, the labeling index of p21 + / + cells was low (< 5 %) whereas the labeling index of p21 - / - cells was high (> 30 %).
In addition, an inverse relationship between the expression of SA - beta - Gal activity and telomerase activity was noted in cells undergoing immortalization.
Susan Amara, USA - «Regulation of transporter function and trafficking by amphetamines, Structure - function relationships in excitatory amino acid transporters (EAATs), Modulation of dopamine transporters (DAT) by GPCRs, Genetics and functional analyses of human trace amine receptors» Tom I. Bonner, USA (Past Core Member)- Genomics, G protein coupled receptors Michel Bouvier, Canada - Molecular Pharmacology of G protein - Coupled Receptors; Molecular mechanisms controlling the selectivity and efficacy of GPCR signalling Thomas Burris, USA - Nuclear Receptor Pharmacology and Drug Discovery William A. Catterall, USA (Past Core Member)- The Molecular Basis of Electrical Excitability Steven Charlton, UK - Molecular Pharmacology and Drug Discovery Moses Chao, USA - Mechanisms of Neurotophin Receptor Signaling Mark Coles, UK - Cellular differentiation, human embryonic stem cells, stromal cells, haematopoietic stem cells, organogenesis, lymphoid microenvironments, develomental immunology Steven L. Colletti, USA Graham L Collingridge, UK Philippe Delerive, France - Metabolic Research (diabetes, obesity, non-alcoholic fatty liver, cardio - vascular diseases, nuclear hormone receptor, GPCRs, kinases) Sir Colin T. Dollery, UK (Founder and Past Core Member) Richard M. Eglen, UK Stephen M. Foord, UK David Gloriam, Denmark - GPCRs, databases, computational drug design, orphan recetpors Gillian Gray, UK Debbie Hay, New Zealand - G protein - coupled receptors, peptide receptors, CGRP, Amylin, Adrenomedullin, Migraine, Diabetes / obesity Allyn C. Howlett, USA Franz Hofmann, Germany - Voltage dependent calcium channels and the positive inotropic effect of beta adrenergic stimulation; cardiovascular function of cGMP protein kinase Yu Huang, Hong Kong - Endothelial and Metabolic Dysfunction, and Novel Biomarkers in Diabetes, Hypertension, Dyslipidemia and Estrogen Deficiency, Endothelium - derived Contracting Factors in the Regulation of Vascular Tone, Adipose Tissue Regulation of Vascular Function in Obesity, Diabetes and Hypertension, Pharmacological Characterization of New Anti-diabetic and Anti-hypertensive Drugs, Hypotensive and antioxidant Actions of Biologically Active Components of Traditional Chinese Herbs and Natural Plants including Polypehnols and Ginsenosides Adriaan P. IJzerman, The Netherlands - G protein - coupled receptors; allosteric modulation; binding kinetics Michael F Jarvis, USA - Purines and Purinergic Receptors and Voltage-gated ion channel (sodium and calcium) pharmacology Pain mechanisms Research Reproducibility Bong - Kiun Kaang, Korea - G protein - coupled receptors; Glutamate receptors; Neuropsychiatric disorders Eamonn Kelly, Prof, UK - Molecular Pharmacology of G protein - coupled receptors, in particular opioid receptors, regulation of GPCRs by kinasis and arrestins Terry Kenakin, USA - Drug receptor pharmacodynamics, receptor theory Janos Kiss, Hungary - Neurodegenerative disorders, Alzheimer's disease Stefan Knapp, Germany - Rational design of highly selective inhibitors (so call chemical probes) targeting protein kinases as well as protein interaction inhibitors of the bromodomain family Andrew Knight, UK Chris Langmead, Australia - Drug discovery, GPCRs, neuroscience and analytical pharmacology Vincent Laudet, France (Past Core Member)- Evolution of the Nuclear Receptor / Ligand couple Margaret R. MacLean, UK - Serotonin, endothelin, estrogen, microRNAs and pulmonary hyperten Neil Marrion, UK - Calcium - activated potassium channels, neuronal excitability Fiona Marshall, UK - GPCR molecular pharmacology, structure and drug discovery Alistair Mathie, UK - Ion channel structure, function and regulation, pain and the nervous system Ian McGrath, UK - Adrenoceptors; autonomic transmission; vascular pharmacology Graeme Milligan, UK - Structure, function and regulation of G protein - coupled receptors Richard Neubig, USA (Past Core Member)- G protein signaling; academic drug discovery Stefan Offermanns, Germany - G protein - coupled receptors, vascular / metabolic signaling Richard Olsen, USA - Structure and function of GABA - A receptors; mode of action of GABAergic drugs including general anesthetics and ethanol Jean - Philippe Pin, France (Past Core Member)- GPCR - mGLuR - GABAB - structure function relationship - pharmacology - biophysics Helgi Schiöth, Sweden David Searls, USA - Bioinformatics Graeme Semple, USA - GPCR Medicinal Chemistry Patrick M. Sexton, Australia - G protein - coupled receptors Roland Staal, USA - Microglia and neuroinflammation in neuropathic pain and neurological disorders Bart Staels, France - Nuclear receptor signaling in metabolic and cardiovascular diseases Katerina Tiligada, Greece - Immunopharmacology, histamine, histamine receptors, hypersensitivity, drug allergy, inflammation Georg Terstappen, Germany - Drug discovery for neurodegenerative diseases with a focus on AD Mary Vore, USA - Activity and regulation of expression and function of the ATP - binding cassette (ABC) transporters
The percentage of HOSE 6 - 3 cells expressing SA - beta - Gal activity was highest (39.2 %) at the crisis stage.
Our results showed a low percentage (12.0 %) of HOSE 6 - 3 cells expressing SA - beta - Gal activity at the pre-crisis stage.
One way the brain eliminates the amyloid - beta typically produced by cell activity in the brain is by moving it to the spinal fluid for disposing of.
Reduced metabolic activity of brain cells and neurons means less brain activity and a decreased ability of the brain to clear abnormal structures like the beta - amyloid plaques associated with Alzheimer's disease.
Beta - eudesmol also suppressed NF - KappaB and lowered the activity of the immune mast cells from which pro-inflammatory chemicals are churned out (study).
Raw cacao also contains the essential mineral magnesium, vital for the healthy activity of your cells, and vitamin A, which your body metabolizes into beta - carotene, a powerful antioxidant.
The combination of grape extract and physical activity offers more protection than physical activity alone 06.03.2018 Betaine forces fat cells to eat themselves 17.02.2018 Low intensity cardio before breakfast burns more fat if you take some L - phenylalanine 29.12.2017 Slimming goes better with a couple of tablespoons of chia daily 23.12.2017 Alpha - linolenic acid - diacylglycerol steps up fat burning 16.11.2017 When children take 8 g inulin daily their fat layers stop growing 09.08.2017 Enhanced fat burning through green and white tea - brown fat cells play key role 13.07.2017 Another fat browner: curcumin 27.04.2017 Two cups of green tea daily results in more brown fat 25.04.2017 Small amount of beta - cryptoxanthin reduces fat percentage 20.03.2017 The unprecedented possibilities of the Horny Goat Weed - leucine cocktail 13.03.2017 L - Histidine supplementation breaks down fat 19.11.2016 Psyllium boosts chance of successful weight loss 30.09.2016 Animal study: lose fat with acai 22.09.2016 Nicotinamide - riboside transforms muscle cells into super muscle cells 27.07.2016 Overweight and depressed?
Another study showed that treatment with 200 mg / kg of coriander seed extracts significantly increased the activity of insulin - secreting beta cells in comparison with the diabetic control rats.