Sentences with phrase «beta cell mass»

Thereby, the different phases of diabetes pathogenesis are characterized by distinct alterations of beta cell mass and / or function.

Chronic treatment with a glucokinase activator delays the onset of hyperglycaemia and preserves beta cell mass in the Zucker diabetic fatty rat.

The analysis found the mice that were exposed to BPA had a significant decrease in beta cell mass and lower levels of insulin secretion than the control animals.

«While expanding beta cell mass may still be desirable for future diabetes therapy, improving the local environment of the otherwise healthy aged beta cell could prevent age - associated deterioration in glucose homeostasis and thereby promote healthy ageing, which is conceptually novel and highly exciting,» says Per - Olof Berggren.

Not exact matches

Unlike transplanted beta cells — or other types of real cells genetically engineered to release insulin for diabetes treatment (SN: 1/15/11, p. 9)-- these artificial cells could be mass - produced and have a much longer shelf life than live cells, says study coauthor Zhen Gu, a biomedical engineer at the University of North Carolina at Chapel Hill.

In their work, the researchers also show how TGF - beta can be used in stem cell cultures to mass - produce nerve cells which in turn produce the signalling substance serotonin.

Based on these findings we believe that parallel targeting of beta cell function and mass is necessary to successfully treat diabetes.

Beta - cell mass dynamics in Zucker diabetic fatty rats.