Sentences with phrase «beta cell proliferation»

In addition to revealing details on how the tribbles protein may hamper insulin secretion, the study suggested ways in which it may increase beta cell death and decrease beta cell proliferation.

Previous studies of beta cell proliferation generally have focused on mechanisms that kick off the cell cycle that leads to successful cell division.

Not exact matches

The process involves the reversion of delta cells (which produce somatostatin, another pancreatic hormone) to a precursor - like cell state, with proliferation and later reconstitution of the populations of beta and delta cells.

Although beta cells proliferate robustly during the first decade or so of life, this proliferation slows dramatically with age.

Over several years, Dr. Stewart and colleagues unraveled genes and signaling pathways that drive multiplication (proliferation) of beta cells, and then confirmed proposed mechanisms with gene therapy.

To explore the feasibility of this approach, Gittes and first author Xiangwei Xiao of the University of Pittsburgh School of Medicine engineered an AAV vector to deliver to the mouse pancreas proteins called Pdx1 and MafA, which support beta cell maturation, proliferation, and function.

Better understanding of the beta - cell proliferation process eventually may lead toward therapies for diabetes patients, whose supplies of these cells often shrink over time, says Rohit Kulkarni, M.D., Ph.D., a Joslin Senior Investigator and senior author on a paper about the work published in the journal Cell Metabolcell proliferation process eventually may lead toward therapies for diabetes patients, whose supplies of these cells often shrink over time, says Rohit Kulkarni, M.D., Ph.D., a Joslin Senior Investigator and senior author on a paper about the work published in the journal Cell MetabolCell Metabolism.

Increased transforming growth factor beta expression inhibits cell proliferation in vitro, yet increases tumorigenicity and tumor growth of Meth A sarcoma cells.

beta - Cells at the crossroads: choosing between insulin granule production and proliferation.

In addition to its structural role in epithelial junctions, beta - catenin activates TCF -4-mediated transcription of genes required for cell proliferation.