Sentences with phrase «better animal models for»

There is an urgent need for better animal models for laboratory research to study the Zika virus and potential treatments.

The key problem for research on smallpox is that there is no good animal model for the disease.

«There hasn't been a good animal model for any kind of speech disorder,» says study author Wan - chun Liu, a senior research associate in Fernando Nottebohn's Laboratory of Animal Behavior.

Cultural stigma against diseases that some falsely believe to be weaknesses of character prevent people from coming forward for trials — a problem when there are no good animal models for diseases like depression and schizophrenia.

Critics charge that rabbits are not good animal models for human brain diseases and note that the dialysis patients suffered from dialysis encephalopathy, or «dialysis dementia,» not Alzheimer's disease.

The loss was bad for the vaccine: In a series of experiments Hensley and his colleagues showed antibodies from humans and ferrets (a good animal model for influenza A studies) that had been exposed to the egg - grown vaccine did not effectively kill the circulating sugar - adorned viruses.

The project began in 2009 when Krasnow, frustrated by the lack of a good animal model for lung disease — his area of expertise — commissioned three high school interns to search the animal world for something better.

Choosing the best animal model for every experiment is a cornerstone of the research approach taken by Davis Center scientists.

Not exact matches

«What I've tried to do is create a sustainable organic farming model that is good for the earth, the soil, the animals, and the people working on these farms, and helps revitalize rural communities,» said Albert Straus, CEO and founder of Straus Family Creamery.

To better understand their findings, the team examined the animal model for APS1 (i.e. mice with the same genetic defect as human patients with the syndrome) and found that male mice spontaneously developed an inflammatory disease in their prostate glands — a so - called prostatitis — and reacted to transglutaminase 4.

Previously, animal models were all based on the early stage of metabolic dysfunction in the liver, which has allowed the development of good drugs for treating early - stage T2D.

And the enrichments may make the animals better at what they do: serving as important models for human disease.

The animals engage in more natural play behavior, Carlos says, and are better models for psychiatric disorders because they're not unnaturally depressed or anxious.

Stress can affect a wide range of physiologies and behaviors, and researchers are beginning to test whether the additions make the animals better models for depression — and, in the case of these particular fish — retinal regeneration.

As noted by Dr. Vicki Ellingrod — the Chair of this session, «Current state - of - the - art research in both animal models as well as humans point to the link between the gut microbiota and mood and anxiety models, as well as the potential for psychiatric medications to directly affect the gut microbiome.»

A good model system for research is provided by Oesophagostomum dentatum, a roundworm which infects the large intestines of pigs, slowing the animals» growth and leading to significant economic losses.

What is needed for a good animal model, and how are gene - snipping tools changing the game?

They found that, for the same dataset, models that can better describe the data favour sponges at the root of the animal tree, while models that drastically fail to describe the data favour the comb jellies.

«But really, there is an opportunity with appropriate animal models to make a huge difference for the human community as well.»

To better determine the role of specific chemoattractants in type III hypersensitivity, lead author Yoshishige Miyabe, MD, PhD, a research fellow in Luster's lab, used multiphoton intravital microscopy — an imaging technology pioneered for studies of immune cell movements in living animals by CIID investigator and co-author Thorsten Mempel, MD, PhD — to follow in real time the development of IC - induced arthritis in a mouse model of rheumatoid arthritis.

The research showed that moral decisions in the con?ned scope of unavoidable traffic collisions can be explained well, and modeled, by a single value - of - life for every human, animal, or inanimate object.

«For that we needed these very carefully constructed, well - controlled animal models.

Researchers at the University of Minnesota have developed an animal research model for facioscapulohumeral muscular dystrophy (FSHD) to be used for muscle regeneration research as well as studies of the effectiveness of potential therapies for FSHD.

Mead believes ALS is ripe for AI and machine - learning because of the rapid expansion in genetic information about the condition and the fact there are good test - tube and animal models to evaluate drug candidates.

They directly injected into the cerebrospinal fluid of a mouse model of Alzheimer's — adult animals in which plaques were well established — viral vectors carrying genes for one of the three APOE variants or a control protein.

In order to gain a better understanding of this process, the researchers used an animal model, which allowed them to interfere with the lipid metabolism, and to knock out the gene responsible for the relevant enzyme, adipose triglyceride lipase (ATGL).

The search for better treatments for cystic fibrosis has accelerated sharply with the development of a realistic animal model for the disease.

«Future studies on maternal smoking and other environmental, genetic, and epigenetic factors, as well as animal models, should allow identification of the biological mechanisms responsible for these associations.

The zebrafish's transparency, small size, and rapid reproduction make it one of the best models for studying how animals and bacteria «talk» to each other, she adds.

Such animals would be better than existing animal models for testing potential new treatments, he suggests.

These findings are promising for developing a preclinical, large animal model of Huntington's disease for assessing new therapeutics, which could ultimately provide better treatment options, including altering the course of the disease.

«The development of this microfluidic lung model, as well as other organs - on - chip, holds the promise of improving the physiological relevance of cellular models for more accurate prediction of the effects of toxicants and drugs on humans, and for reducing the use of animals in medical and pharmaceutical research,» said Sonia Grego, Ph.D., research scientist at RTI and the project's principal investigator.

Researchers have developed the first animal model simulating the eye complications associated with the thyroid condition Graves» disease, a breakthrough that could pave the way for better treatments, according to a recent study accepted for publication in The Endocrine Society's journal Endocrinology.

Investigating mouse models for biological for research The congress aims to promote the International Mouse Phenotyping Consortium (IMPC) mouse lines, importance of mouse phenotyping & clinical and drug discovery collaboration, to present progresses performed by IMPC with regards CRISPR editing genome, rare diseases, microbiota and ageing pipeline, as well as illustration of examples of scientific projects about «Animal models for human diseases» and recent developments in mouse models phenotyping imaging.

Understanding cattle movement patterns as well as the connectivity of the various sectors of the U.S. cattle industry and incorporating these in the models would allow USDA Animal Plant Health Inspection Service (APHIS) Veterinary Services (VS) to develop more effective regulations and control strategies for various animal diseases, including boviAnimal Plant Health Inspection Service (APHIS) Veterinary Services (VS) to develop more effective regulations and control strategies for various animal diseases, including bovianimal diseases, including bovine TB.

Biomedcode welcomes suggestions and proposals for the development of novel animal disease models as well as for the generation of animals humanized for targets of interest.

Researchers at the MDI Biological Laboratory have been using animal models beyond the well - known laboratory mouse for decades.

Introduced in 1992 by Kim and Chung (1), spinal nerve L5 / L6 ligation (SNL) in rats has become well recognized and accepted as an animal model for mechanistic studies of peripheral neuropathy and for screening of novel analgesics.

As previously noted, these animals accumulate CTTAS in vulnerable brain regions in a pattern consistent with that observed in humans suffering with diagnosed PD and LBD, [16] making them a good model for testing mAbs intended to target these species.

For large animals, like hippo and buffalo, their sensitivity to change — especially with predictions of more frequent and prolonged drought — means they don't do well in any of the future scenarios modelled by the park's scientific teams.

You damn well better believe that there is research going on in animal models — what does she expect, that scientists should mutagenize human mothers and chop up baby brains for this work?

The role of new genetic pathways in cancer biochemistry (the genome mutation profiles), the identification of the key targets and their validation, as well as utilization of new knock - out or knock - in animal models for such studies are among topics that will be discussed.

Slicer touches on a very significant problem for glucosepane research: no good animal models.

«We wanted to provide a forum for researchers to trade notes on best practices when assessing behaviors in healthy and diseased animal models,» explained Gill, who organized the event.

A molecule containing three oxygen atoms, computer models suggest that ozone on Venus is formed when sunlight breaks up carbon dioxide molecules and releases oxygen atoms, which are swept around to the planet's nightside by winds where they can then combine to form unstable, three - atom ozone molecules, as well as much more stable, two - atom molecules essential for animals.

The congress aims to promote the International Mouse Phenotyping Consortium (IMPC) mouse lines, importance of mouse phenotyping & clinical and drug discovery collaboration, to present progresses performed by IMPC with regards CRISPR editing genome, rare diseases, microbiota and ageing pipeline, as well as illustration of examples of scientific projects about «Animal models for human diseases» and recent developments in mouse models phenotyping imaging.

Their work encompasses several strategies, including: developing FL - HCC animal models to characterize tumor - immune interactions, exploring if a mutated protein associated with FL - HCC could be targeted by immunotherapy, identifying immune checkpoints that could potentially serve as targets for immunotherapy as well as biomarkers for analyzing patients, and evaluating the effectiveness of immunotherapy strategies against FL - HCC patient samples in the lab.

This unique international event will provide the attendees with an innovative program focused on the best practices in the use of the mouse model for biomedical and basic research; this program also addresses the item of continuing professional education consistent with the new European directive requirement for lab animal protection in experiments.

The main research activity (located in central Paris and vicinity at Orsay) regroups to date 16 technology platforms and services offering state ‐ of ‐ the - art expertise and equipment from small molecule chemistry to omcs, super-resolution microscopy, sophisticated radiation sources and various animal models, including xenografts directly derived from patients, in order to promote the best environment and support for research activities.

We have good mouse models for studying Huntington's disease, but mice are short - lived animals, whereas sheep can live to at least 12 years.