Sentences with phrase «better animal models of»

The UCSF TCORS also has two developmental projects — one on risk perceptions of smoking by older Americans, and another to develop better animal models of the cardiovascular effects of secondhand smoke and exposure to other tobacco products, said Glantz.

From accelerating the identification and validation of novel therapeutic targets, to creating better animal models of human diseases in a shorter time frame, to reducing the number of failed products, Crispr looks set to shave millions off R&D costs and boost drug discovery, she says.

Wild H5N1 viruses can not latch on tothe cells in a person's nose and throat, but the mutant strains created by Fouchier and Kawaoka can spread between ferrets, which are viewed as a good animal model of flu transmission between humans.

Here, we used Splenda as a means to test the combined effect of the commercial ingredients and used one of the best animal models of ileal Crohn's disease.»

The finding, by researchers at the University of Illinois at Chicago College of Medicine, was reported July 16 at the Alzheimer's Association International Conference in Copenhagen by Mary Jo LaDu, who in 2012 developed a transgenic mouse that is now regarded as the best animal model of the human disease.

Furthermore, the heterozygous knock in mouse serves as a better animal model of the human disorder, as compared to the homozygous mouse, given that Huntington disease homozygosity is very rare in humans.

Not exact matches

[104] In place of WS, animal protectionists hold up their work with sheep producers of Marin County, California as a better coyote management model.

«What I've tried to do is create a sustainable organic farming model that is good for the earth, the soil, the animals, and the people working on these farms, and helps revitalize rural communities,» said Albert Straus, CEO and founder of Straus Family Creamery.

Their dinosaurs and animal models are by far the best I have come across in my almost 10 years of being a parent.

They then tested the contributions of samples from breast milk as well as individual molecules in both animal and cellular models of infection, measuring the length of time until resolution.

Understanding of the development of DPN is mostly obscure, partly due to the lack of good animal models available.

Previously, animal models were all based on the early stage of metabolic dysfunction in the liver, which has allowed the development of good drugs for treating early - stage T2D.

Stress can affect a wide range of physiologies and behaviors, and researchers are beginning to test whether the additions make the animals better models for depression — and, in the case of these particular fish — retinal regeneration.

As noted by Dr. Vicki Ellingrod — the Chair of this session, «Current state - of - the - art research in both animal models as well as humans point to the link between the gut microbiota and mood and anxiety models, as well as the potential for psychiatric medications to directly affect the gut microbiome.»

A good model system for research is provided by Oesophagostomum dentatum, a roundworm which infects the large intestines of pigs, slowing the animals» growth and leading to significant economic losses.

Nadeau also studies the potential impacts of climate change on species around the globe, using modeling, field observation and experiments to predict where species are most vulnerable and determine how conservation groups can best mitigate the negative impacts of climate change on animal populations.

While mouse models have traditionally been used in studying the genetic disorder, Deng said the animal model is inadequate because the human brain is more complicated, and much of that complexity arises from astroglia cells, the star - shaped cells that play an important role in the physical structure of the brain as well as in the transmission of nerve impulses.

The study — which looked at the action of Substance P within nerve cells in the lab and in animal models — focused on acute pain, but Professor Gamper aims to look at its role within chronic pain as well.

Herzberg said his stories dealt «with obviousness that is not obvious... the stethoscope as the eternal symbol of doctors, mice as our best animal model, eels as simple, almost boring, river fishes.

Schmidt says, «These people can test compounds or antibodies in well - defined animal models that are representative of a human disease.»

They found that, for the same dataset, models that can better describe the data favour sponges at the root of the animal tree, while models that drastically fail to describe the data favour the comb jellies.

«Most pain medications that have been tested in the past decade have failed in phase II human trials despite performing well in animal models,» notes Clifford Woolf, MD, PhD, director of Boston Children's F.M. Kirby Neurobiology Center and a co-senior investigator on the study with Michael Costigan, PhD.

This anxious behavior mirrored that of CdLS patients, while autopsied brain tissue from individuals with CdLS showed symptoms of disease that matched those of the experimental mice suggesting that they were a good animal model.

To better determine the role of specific chemoattractants in type III hypersensitivity, lead author Yoshishige Miyabe, MD, PhD, a research fellow in Luster's lab, used multiphoton intravital microscopy — an imaging technology pioneered for studies of immune cell movements in living animals by CIID investigator and co-author Thorsten Mempel, MD, PhD — to follow in real time the development of IC - induced arthritis in a mouse model of rheumatoid arthritis.

The research showed that moral decisions in the con?ned scope of unavoidable traffic collisions can be explained well, and modeled, by a single value - of - life for every human, animal, or inanimate object.

«There hasn't been a good animal model for any kind of speech disorder,» says study author Wan - chun Liu, a senior research associate in Fernando Nottebohn's Laboratory of Animal Behanimal model for any kind of speech disorder,» says study author Wan - chun Liu, a senior research associate in Fernando Nottebohn's Laboratory of Animal BehAnimal Behavior.

Cultural stigma against diseases that some falsely believe to be weaknesses of character prevent people from coming forward for trials — a problem when there are no good animal models for diseases like depression and schizophrenia.

Researchers at the University of Minnesota have developed an animal research model for facioscapulohumeral muscular dystrophy (FSHD) to be used for muscle regeneration research as well as studies of the effectiveness of potential therapies for FSHD.

«There's a growing demand, as animal models aren't mirroring the diseases too well,» says David Dexter, director of the bank.

CDNF has shown strong neuroprotective and even restorative properties in animal models of Parkinson's disease as well as spinal and peripheral nerve injuries.

Mead believes ALS is ripe for AI and machine - learning because of the rapid expansion in genetic information about the condition and the fact there are good test - tube and animal models to evaluate drug candidates.

They directly injected into the cerebrospinal fluid of a mouse model of Alzheimer's — adult animals in which plaques were well established — viral vectors carrying genes for one of the three APOE variants or a control protein.

In order to gain a better understanding of this process, the researchers used an animal model, which allowed them to interfere with the lipid metabolism, and to knock out the gene responsible for the relevant enzyme, adipose triglyceride lipase (ATGL).

Significantly, disabling both anti-apoptotic proteins, Bcl - 2 and Bcl - xL, in conjunction with Mcl - 1, caused profound cell death of leukemia cells in the test tube as well as in animal models of AML.

«Although this is basic scientific research using animal models, these studies are shedding light on the molecular mechanisms that control male fertility, and are helping us to better understand the causes of many cases of infertility and enabling new horizons to be opened up in the development of therapeutic targets and strategies to combat it,» explained Dr Subirán.

DNA vaccines have been studied in animal models of viral, bacterial, and parasitic disease, as well as animal models of tumors.

The loss was bad for the vaccine: In a series of experiments Hensley and his colleagues showed antibodies from humans and ferrets (a good animal model for influenza A studies) that had been exposed to the egg - grown vaccine did not effectively kill the circulating sugar - adorned viruses.

Major recent advances in understanding GVHD's underlying biology, improved animal models, better targeting of interventions, and more systematic clinical trials are finally moving beyond «accumulated sketchy information,» Pavletic says.

The search for better treatments for cystic fibrosis has accelerated sharply with the development of a realistic animal model for the disease.

Though the scientists don't know if such individual and pack behavior is a common occurrence, observations like these on Isle Royale provide insight into how animal societies function as well as the vicissitudes of the food chain cycle on Isle Royale, also helping to inform other models of the natural world.

In contrast to previous animal models of NMO that generally produced disseminated lesions, the new localized model has a single well - demarcated inflammatory lesion, allowing precise investigation of the correlation between the lesion with the deficit in motor function disrupting the corticospinal tract.

«Future studies on maternal smoking and other environmental, genetic, and epigenetic factors, as well as animal models, should allow identification of the biological mechanisms responsible for these associations.

Brendan Wintle at the University of Melbourne, Australia, has developed an alternative model that includes data on previous searches in remote regions, as well as aspects of the animal's biology and behaviour.

When using a well established model of colorectal cancer, the researchers observed that dietary emulsifier consumption was sufficient to make the animals more susceptible to developing colonic tumors because this created and maintained a pro-inflammatory environment associated with an altered proliferation / apoptosis (cell death) balance.

The zebrafish's transparency, small size, and rapid reproduction make it one of the best models for studying how animals and bacteria «talk» to each other, she adds.

The project began in 2009 when Krasnow, frustrated by the lack of a good animal model for lung disease — his area of expertise — commissioned three high school interns to search the animal world for something better.

Though they found a few elements of the fossilized skull, the researchers chose to model the skull after a few well - preserved skulls of smaller animals related to titanosaurs, and «scaled it up to the size that this animal would be,» Norell said.

«Because plants make their decisions based on physiological processes and are not distracted from the best course of action by subjective thought, they could even be better models than animals and people,» says Bernhard Schmid from the University of Zurich.

These findings are promising for developing a preclinical, large animal model of Huntington's disease for assessing new therapeutics, which could ultimately provide better treatment options, including altering the course of the disease.

«The Medaka experiment finding of new genes affected by microgravity provides a good animal model to clarify this mechanism.»