Sentences with phrase «better models of human disease»

Gladstone scientists are engineering tissues from stem cells to create better models of human disease.

She notes that biomedical researchers use macaques in part because they can offer good models of human disease.

Not exact matches

With our human gut - on - a-chip, we can not only culture the normal gut microbiome for extended times, but we can also analyze contributions of pathogens, immune cells, and vascular and lymphatic endothelium, as well as model specific diseases to understand complex pathophysiological responses of the intestinal tract.»

«Computational models like this one might one day be able to predict the clinical course of a disease or injury, as well as make it possible to do less expensive testing of experimental drugs and interventions to see whether they are worth pursuing with human trials,» he said.

From accelerating the identification and validation of novel therapeutic targets, to creating better animal models of human diseases in a shorter time frame, to reducing the number of failed products, Crispr looks set to shave millions off R&D costs and boost drug discovery, she says.

«While it seems that genetics makes a substantial difference to the severity of the heart disease in our models, it does suggest that in humans we may be able to better diagnose heart valve disease in people with rheumatoid arthritis in the future.»

Schmidt says, «These people can test compounds or antibodies in well - defined animal models that are representative of a human disease.»

Desgrosellier said the team will follow up with mouse models containing tumor fragments from patients to better reflect the diversity of cell types present in human disease.

The human cell - based disease model is expected to lead to a better understanding of these disorders and other illnesses, Hsiao said.

With that in mind, the Penn Vet team chose to examine two of their well - established canine models of RP, which recapitulate many features of the human diseases, each involving mutations in different genes.

«This research project is a prime example of how mouse models can help us to better understand cancer diseases in human beings,» says Sabine Harlander.

But if homologous recombination could be worked out in human (embryonic) stem cells, then cardiomyocytes with mutations in ion channels could be derived, as well as a large number of other very useful disease models of other tissues.

His research focuses on the cancer biology, drug resistance, and signaling pathway networks of human diseases as well as on ways to model these disorders.

«In the future, such efforts could allow us to much better understand human - microbiome interactions, model malnutrition disorders and inflammatory diseases of the gut, and perform personalized drug testing,» said co-first author Alessio Tovaglieri, a Graduate Student at the Department of Health Science and Technology at ETH Zurich in Switzerland, who performs his thesis work on Ingber's team.

Overall, this work illustrates that better understanding the basic biology of the immune system in preclinical models may open up a window for the development of novel treatments for human autoimmune disease.

The researchers hope their study leads to better measures for modeling and predicting infectious disease transmission, but there are still open questions about the human - wildlife interface of disease.

The finding, by researchers at the University of Illinois at Chicago College of Medicine, was reported July 16 at the Alzheimer's Association International Conference in Copenhagen by Mary Jo LaDu, who in 2012 developed a transgenic mouse that is now regarded as the best animal model of the human disease.

No, studies using animal models of human disease as well as «humanized mice» are expressly forbidden.

Investigating mouse models for biological for research The congress aims to promote the International Mouse Phenotyping Consortium (IMPC) mouse lines, importance of mouse phenotyping & clinical and drug discovery collaboration, to present progresses performed by IMPC with regards CRISPR editing genome, rare diseases, microbiota and ageing pipeline, as well as illustration of examples of scientific projects about «Animal models for human diseases» and recent developments in mouse models phenotyping imaging.

Human embryonic stem cells derived from affected embryos during a pre-implantation diagnostic (PGD), as well as the conversion of somatic cells, such as skin fibroblasts, into induced pluripotent stem cells by genetic manipulation, offer the unique opportunity to have access to a large spectrum of disease - specific cell models.

It now looks like many of these traits could be controlled by the combination of genes between different strains, thus producing mice that are better models for human disease.»

Click to view article: Mouse model of human disease still good, but significant differences exist

Researchers have used CRISPR to develop a pig model of Huntington's disease that better mimics how the disease progresses in humans.

PHENOMIN - ICS services will ultimately help the scientific community in the use the mouse model, first to develop a complete functional annotation of the human genome and second to better understand human diseases and their underlying physiological and pathological basis.

Now this latter element, it turns out that we have a real opportunity because as Dave Calkins and others have now demonstrated very beautifully in animal models, and we even have very good data now in humans; in glaucoma there's an injury that happens first, and it's the death or loss of the cell that happens later in the disease.

Moreover, PHENONIM - ICS is involved in European projects presenting a strong impact on human health: Interreg CARDIOGENE (Genetic mechanisms of cardiovascular diseases), GENCODYS (Genetic and epigenetic networks involved in cognitive dysfunctions), AgedBrainSYSBIO (Basic studies of brain aging), as well as projects in partnership with industry: MAGenTA (an Industrial Strategic Innovation project supported by Bpifrance about the treatment of major urogenital diseases) and CanPathPro (H2020 program), to develop a predictive modeling platform of signaling pathways involved in cancers.

Importantly, some freely - available resources that link model organism genes to human diseases will be presented to promote a better understanding of the mammalian genome.

The congress aims to promote the International Mouse Phenotyping Consortium (IMPC) mouse lines, importance of mouse phenotyping & clinical and drug discovery collaboration, to present progresses performed by IMPC with regards CRISPR editing genome, rare diseases, microbiota and ageing pipeline, as well as illustration of examples of scientific projects about «Animal models for human diseases» and recent developments in mouse models phenotyping imaging.

Working with Dr. Weiskopf, we established a model of human dengue disease using HLA transgenic mouse strains, and characterized human dengue - specific CD8 + and CD4 + T - cell responses in natural infection as well as following vaccination.

The BAC (Bacterial Artificial Chromosome) mouse model of Huntington's disease expresses the full length human htt transgene and has been well - characterized for its progressively impaired motor function.

Although the mouse remains the most cost - effective choice for comprehensive phenotyping, the rat remains a better model for a number of human conditions, including cardiovascular disease, diabetes and behavioral disorders.

Fruit flies serve as a good model organism for understanding the molecular mechanisms behind many human diseases — around 75 percent of disease - causing genes are found in the species in a similar form.

Dr. Falk is also PI of an NIH, pharma, and philanthropic funded translational research laboratory group at CHOP that investigates the causes and global metabolic consequences of mitochondrial disease, as well as targeted therapies, in C. elegans, zebrafish, mouse, and human tissue models of genetic - based respiratory chain dysfunction, and directs multiple clinical treatment trials in mitochondrial disease patients.

Furthermore, the heterozygous knock in mouse serves as a better animal model of the human disorder, as compared to the homozygous mouse, given that Huntington disease homozygosity is very rare in humans.

Gage and Ghosh discuss how human skin cells induced to return to an immature state («induced pluripotent stem cells» or IPS cells) are revolutionizing our understanding and treatment of mental and neurodegenerative disorders, such as Parkinson's disease, as well as leading to new models of drug development for all diseases.

For three years now we have been working on human cell models of rare neurodegenerative diseases with special emphasis on neuroacanthocytosis, neuronal ceroid lipofuscinosis as well as motor neuron degeneration (using iPS cells).

«Infectious disease can mean making trade - offs between the risks and rewards of meeting others,» says Eli Fenichel, Arizona State University assistant professor and co-organizer of a transdisciplinary working group at NIMBioS that has developed a better model for understanding the role human decisons play in the spread of disease.

Animal models are necessary to develop improved diagnostics and therapeutics, as well as understanding the basic pathophysiology of common human laryngeal diseases.

Oral administration of Lactobacillus microbes has been demonstrated to have beneficial therapeutic effect in experimental models of neurological disease, as well as in recent clinical trials on depression and anxiety disorders in humans.

The emphasis is on developing intellectual abilities and research skills through investigations of infectious diseases of food - producing, companion, and aquatic animals, as well as animal models for human disease.

This model is important in that it addresses a significant disease and can model how to identify and change human variables to better improve other aspects of the complex relationships that we have with domestic and companion animals.