Sentences with phrase «better randomized studies»

Not exact matches

A randomized, blinded study of the impact of intercessory prayer on spiritual well - being in patients with cancer.

He points to research by a Stanford University researcher, Allan K. Mishra, who has studied PRP for years, whose in his most recent published research includes a large multicenter study [8] involving a host of well - respected orthopedic surgeons around the country who followed 230 patients in a double - blind randomized control study [the gold standard for medical research].

Primarily because we do not find the same benefits in better - designed studies — sibling comparison studies and the PROBIT randomized controlled trial.

As with neurobehavior, effects on breastfeeding are poorly studied, and more recent randomized controlled trials comparing exposure to epidural and opiate drugs are especially misleading because opiates have a well - recognized negative effect on early breastfeeding behavior and success.103 — 107

But this doesn't make sense for everything we do in health care, and we know the information we get from randomized controlled trials doesn't always translate well to real life because 1) the restrictions we put on eligibility for studies rarely allows the results to be generalized to the population as a whole and 2) Adherence to the intervention tends to be higher in a randomized controlled trial than in real life which makes the effect seem «better» than it is.

In the evidence pyramid a randomized controlled trial is the highest form of primary research, and a synthesis of studies provides the best evidence.

Our study illustrates that a randomized intervention trial with good socioeconomic information can help assess interventions designed to improve population health not only by examining the intervention effects on primary outcomes but also by evaluating the intervention's impact on socioeconomic inequalities.

Studies of the Nurse Family Partnership model followed children to 6 years and found significant program effects on language and cognitive functioning as well as fewer behaviour problems in a randomized controlled trial study.24 In addition, more recent evaluations of Healthy Families America have shown small, but favourable effects on young children's development.25, 26

Regarding the science criticism, it's impossible to scientifically prove by a placebo - controlled, double - blind, randomized study (the gold standard in science) that AP works better than a more distant style of parenting.

We are «early adopters» of new technologies, if we strongly believe that they appear promising, and if there are good randomized, controlled studies that prove they provide a benefit.

We can not randomize breastfeeding, although it is possible to randomize breast milk: Lucas et al23 conducted an ingenious study in which premature infants who were fed their mother's milk from a bottle did better on follow - up testing than children who were fed formula.

Although some SIDS experts and policy - makers endorse pacifier use recommendations that are similar to those of the AAP, 272,273 concerns about possible deleterious effects of pacifier use have prevented others from making a recommendation for pacifier use as a risk reduction strategy.274 Although several observational studies275, — , 277 have found a correlation between pacifiers and reduced breastfeeding duration, the results of well - designed randomized clinical trials indicated that pacifiers do not seem to cause shortened breastfeeding duration for term and preterm infants.278, 279 The authors of 1 study reported a small deleterious effect of early pacifier introduction (2 — 5 days after birth) on exclusive breastfeeding at 1 month of age and on overall breastfeeding duration (defined as any breastfeeding), but early pacifier use did not adversely affect exclusive breastfeeding duration.

One of the best ways scientists have to prove cause and effect in medicine is to conduct a randomized controlled trial, in which study subjects are randomly assigned to two groups.

The study, called the Bypass Surgery Versus Everolimus - Eluting Stent Implantation for Multivessel Coronary Artery Disease (BEST) trial, is one of only two randomized controlled trials to compare bypass to angioplasty since the introduction of everolimus - eluting stents, a new generation of drug - eluting stent.

«But as a clinician, if there are randomized data that would allow us to go from a pilot study to a phase 3 clinical trial, and if the results are good, then we would have to come back to Francis Collins, and say, «This needs to be exported to other communities and ramped up.»

The determination of each efficacy level was also based on the rigor and quantity of published studies on the drug class: to be in Level A, for example, a class of drugs must have been supported by at least two «Class I» studies — well - designed, double - blind, randomized, placebo - controlled clinical trials.

Randomized controlled studies are now underway to help us better understand the effectiveness of the drug.

A randomized phase III trial finding that a new monoclonal antibody, elotuzumab, added to standard therapy, extended the duration of remission for patients with relapsed multiple myeloma by about five months Findings from two phase III studies showing that children with Wilms tumor who have a specific chromosomal abnormality do better with a more intensive, augmented chemotherapy regimen

«For the first time in a randomized study, the strategy of catheter ablation for atrial fibrillation may be better than the current approach for these patients.

Randomized controlled studies, including one I conducted with funding from the NIH, show that this approach improves well - being, lowering blood pressure and cholesterol while elevating self - esteem.

A well conducted randomized trial is more likely to produce correct results, but a less rigorous study might still satisfy a physician if the risks are low and its potential benefits are great, he says.

An analysis of diagnostic test results from the Prospective Multicenter Imaging Study for Evaluation of Chest Pain (PROMISE) trial — in which patients with stable chest pain were randomized to either anatomic or functional testing as an initial diagnostic strategy — showed that the presence and extent of coronary artery disease detected by CT angiography better predicted the risk for future cardiac events than did measures of exercise tolerance or restricted blood flow to the heart muscle.

African - Americans and men reported the greatest levels of improvement, and the 79 patients who reported moderate levels of anxiety at baseline generally did well over the course of follow - up, whether they were later randomized to the study intervention or not.

Larger, well - designed studies, such as cluster randomized trials, are ultimately needed to confirm the effectiveness of this strategy,» writes Alice Y. Guh, M.D., M.P.H., and L. Clifford McDonald, M.D., of the Centers for Disease Control and Prevention, Atlanta.

But in July researchers published a paper in the New England Journal of Medicine that describes a well - designed, randomized, controlled study of human nutrition — with surprising results.

The researchers also want to add to this current observational study to establish, through randomized controlled trials, that eating fish can lead to better sleep, better school performance and other real - life, practical outcomes.

The original, randomized, open label study, which enrolled 20 outpatient men with cirrhosis and recurrent HE receiving standard - of - care (SOC) treatment, had previously reported that a single FMT enema after antibiotic pretreatment improved cognitive function at Day 20 and reduced HE episodes and hospitalizations over the following 5 months compared with SOC.1 The long - term outcomes of this study, which were presented today at The International Liver Congress ™ 2018 in Paris, France, demonstrated sustained and statistically significant reductions in the number of HE episodes and hospitalizations as well as improvements in cognitive function over 1 year in the men who received FMT compared with the control group.

The trials for chemotherapy side effects — 4 of which were randomized controlled trials — found that medical cannabis was significantly better than anti-nausea drugs standard at the time of study for reducing nausea and vomiting.

Some studies suggested that patients responded well, but they didn't have the controlled, randomized, and blinded design that allows researchers to be sure, says Simon Mardel, a medical officer working on SARS at the World Health Organization (WHO) in Geneva.

Our results suggest the need for future studies involving long - term ambulatory cardiac monitoring to better delineate the risk associated with transient vs persistent perioperative AF, as well as randomized clinical trials to determine optimal strategies for antithrombotic therapy in patients with perioperative AF and a significant burden of other risk factors for stroke,» the authors write.

The study is the first randomized, controlled trial to test whether group classes are a good way to train parents on using an autism therapy.

The study was carried out using the randomized response technique (RRT), which allows for better estimates of unknown cases in response to sensitive questions.

A Phase III Randomized Open - Label Multi-Center Study of Ruxolitinib vs. Best Available Therapy in Patients with Corticosteroid - Refractory Chronic Graft vs Host Disease after Allogenic Stem Cell Transplantation (REACH 3)

Randomized Phase II Study: Corticosteroids + Bevacizumab vs. Corticosteroids + Placebo (BEST) for Radionecrosis after Radiosurgery for Brain Metastases

Various types of meditation have been shown to improve well - being among different populations such as physicians and the general public.14, 15, 16 Preliminary evidence suggests that meditation - based interventions may slow cellular aging rates by increasing telomerase activity, but many such studies lacked an active control group.17, 18 Recent randomized trials in breast cancer suggest that long - term intensive meditation interventions might have positive effects on telomerase activity.

The randomized, double - blind, placebo - controlled study will evaluate the safety and tolerability of multiple doses of NPT088, as well as pharmacokinetics, immunogenicity and pharmacodynamic characteristics, as measured by Aβ and tau PET imaging.

The study is randomized and controlled for all the variables that haven't been well - tested so far — like effectiveness.

A 2007 analysis of the best available studies of adults, including a handful of randomized controlled trials, found that neither calcium supplements nor dairy products reduced the risk of hip fractures in men or women.

According to the researchers, there have been proposals that vitamin C dosages should be more than 15 g / day for the best treatment of colds, but the highest dosages that have so far been looked at in randomized studies have been much lower.

If they weren't randomized (which could represent stacking up the placebo group with very sick patients) then the coconut fat consumers scored slightly better after 45 days in the study.

The latter are examples of Mendelian randomization studies, enabled by the cheap genotyping of the past decade, which can be considered Nature's own randomized clinical trials, and like RCTs, offer some of the best evidence or refutations of a causal role for risk markers.

There doesn't seem to be any randomized, well - controlled studies to look more closely at this diet.

While animal studies show benefits of CoQ10 in supplying energy and functioning as an antioxidant for aging eggs, more well controlled randomized trials in women are needed.

While this single study certainly doesn't constitute a proven scientific outcome, the results of a randomized controlled trial conducted in Boston certainly supports the real - world potential for co-treating our mind, along with our body to achieve better fertility outcomes.

A randomized controlled trial of 75 women with irritable bowel syndrome, for example, reported that mindfulness meditation, the best - studied type of meditation, reduced the severity of symptoms.

A randomized, double - blind, placebo - controlled study (the best study design around), published in Journal of Clinical Endocrinology and Metabolism, showed that soy intake significantly improved insulin resistance, triglycerides, LDL and cholesterol.

In fact, in every study — including the «gold standard» for evidence, randomized controlled trials — VLCKDs perform at least as well and generally better than low - fat diets for this purpose.

Next up was Don't Use Antiseptic Mouthwash, which describes the role the natural good bacteria flora on our tongue plays in the performance - boosting effect of high nitrate vegetables, and Out of the Lab onto the Track, which documented the randomized, double - blind, placebo - controlled crossover studies that convinced the scientific establishment of the real - world effect.

Harry Wang, director of health and mobile product research at Parks Associates, a Dallas - based market research firm, said the study is one of the largest randomized trials of its kind and appears to be well - designed.

Assessing vitamin K status in prospective studies and well - designed randomized... [Read more...]