«Although there appears to be a generally high level of agreement
between the two
diagnostic classification systems in that nearly all individuals with a severe AUD per the DSM - 5 received an ICD - 10 dependence diagnosis,» added Proctor, «there are likely some very important individual differences
between the two groups in terms of their clinical presentation.
Study Selection Criteria for studies for the meta - analyses included published data on the association
between 5 - HTTLPR genotype (SS, SL, or LL), number of stressful life events (0, 1, 2, ≥ 3) or equivalent, and a categorical measure of depression defined by the
Diagnostic and Statistical Manual of Mental Disorders (Fourth Edition) or the International Statistical
Classification of Diseases, 10th Revision (ICD - 10) or use of a cut point to define depression from standardized rating scales.