Taken together, our findings suggest culture — gene coevolution
between allelic frequency of 5 - HTTLPR and cultural values of individualism — collectivism and support the notion that cultural values buffer genetically susceptible populations from increased prevalence of affective disorders.
To further determine the specificity of the mediating role of collectivistic cultural values on the association
between allelic frequency of the 5 - HTTLPR and mental health disorders, we also conducted regression of mediation on 5 - HTTLPR, individualism — collectivism and two mental health disorders included in the 2008 WHO Mental Health Survey, but not previously associated with the 5 - HTTLPR, namely substance abuse and impulse control.
Not exact matches
This hypothesis is supported by the
allelic associations
between a SNP in the human IL15RA gene and endurance athlete status.
When the average
allelic effect does not capture a specific
allelic effect under certain conditions, whether due to genetic background or environmental effects, current methods will not detect the link
between genotype and phenotype.
By contrast, the insecticide - resistance markers display heterogeneous
allelic distributions with significant differences detected
between Central Ugandan (urban) populations relative to Eastern and Southwestern (rural) populations.
Given that ovulatory dysfunction is a key feature of PCOS, one group investigated a cohort of PCOS patients to determine if there was an association with this polymorphism.68 They reported significant differences in the genotype distribution and
allelic frequencies
between controls and PCOS patients that supported a correlation with the G / A polymorphism.68 To date, the underlying mechanism has not been established.
Statistically significant
allelic differentiation was found
between older (1927 and 1941) and newer (2000) Santa Rosa samples (χ216 = 58.0, P < 0.001); however, the magnitude of differentiation was small (FST = 0.029, 95 % CI = 0.01 — 0.05).
Here, we examined the association
between cultural values of individualism — collectivism and
allelic frequency of the serotonin transporter functional polymorphism (5 - HTTLPR) as well as the role this culture — gene association may play in explaining global variability in prevalence of pathogens and affective disorders.
During the anticipation phase (the time
between presentation of cues and potential reward receipt), the contrast of interest was the effect of
allelic group on differences in brain activation for incentive versus non-incentive trials.