Sentences with phrase «between early life adversity»

Previous research has reported that a functional polymorphism in the monoamine oxidase A (MAOA) gene promoter can moderate the association between early life adversity and increased risk for violence and antisocial behavior.

Associations between early life adversity and executive function in children adopted internationally from orphanages

I completed my MA thesis on the association between early life adversity and developing stress physiology in free - ranging juvenile rhesus macaques on Cayo Santiago.

Not exact matches

Some studies document hyperreactivity of the SNS and HPA axis following early - life adversity (15 ⇓ ⇓ ⇓ — 19) and others observe blunted HPA axis reactivity (20 ⇓ — 22) or discordance between SNS and HPA axis responses (23).

The analysis also examined interactions between the life stage (13 — 19, 20 — 29, 30 + years) of respondents and each childhood adversity, as well as the influence each adversity had on early - onset, middle - onset and later - onset suicidality.

Although this is the first prospective longitudinal study to investigate this mediational hypothesis in a systematic manner, our findings are consistent with previous findings indicating that disruption of interpersonal relationships is a predominant risk factor for suicide10, 13,49 and that interpersonal conflict or separation during adulthood partially mediated an association between neglectful overprotective parenting and subsequent suicide attempts.23 The present findings are also consistent with research indicating that stressful life events mediated the association between childhood adversities and suicidal behavior during adolescence or early adulthood, 8 that suicide is multidetermined, 2 and that youths who experience numerous adversities during childhood and adolescence are at a particularly elevated risk for suicide.18, 22,49

Because our review of the literature indicated that this set of risk factors and outcomes had not previously been investigated in a thoroughly comprehensive and systematic manner with longitudinal data, data from the Children in the Community Study, 27 a prospective longitudinal investigation, were used to investigate whether negative life events or severe interpersonal difficulties during adolescence mediate the association between childhood adversities and suicide attempts during late adolescence or early adulthood.

Childhood sexual abuse and childhood physical abuse are among the strongest predictors of psychiatric pathology and severity of clinical course, including suicide.2,4 - 14 The influence of childhood sexual abuse and childhood physical abuse on psychological development is thought to be mediated directly by changes in cognitive processing of threatening stimuli,15 - 18 resulting in enhanced negative affect to daily life stressors.19 Although there is a clear link between early - life adversity and psychopathology, very little is known about the molecular mechanisms responsible for the long - lasting behavioral consequences of childhood abuse.

Analyses of contingency tables were conducted to investigate associations between childhood adversities, negative life events, severe interpersonal difficulties, and suicide attempts during late adolescence or early adulthood.

This article, by Center Director Jack P. Shonkoff and Pat Levitt, science director of the National Scientific Council on the Developing Child, advocates for greater synergy between neuroscience and innovation in early childhood policy to improve life outcomes for children experiencing significant adversity.