Earlier evidence for cross-protection
between the flaviviruses — as these agents are called — was contradictory.
The research, published and featured in the Spot Light section of the December edition of the Journal of Virology, examines a previously unknown connection
between flaviviruses — a classification of viruses that include West Nile virus, Dengue virus and tick - borne encephalitis virus — and organelles (a specialized subunit within a cell) known as peroxisomes that help coordinate the body's immune responses.
Not exact matches
Further, current serologic tests often can't distinguish
between related
flavivirus infections in dengue - endemic regions.
There are already tests on the market, but none of them can tell the difference
between these individual
flaviviruses.
This new research tool (Figure 2) allows for the rapid analysis of biological specimens (serum, plasma, CSF, etc.) for high - throughput discovery of biomarkers that may be able to discriminate
between these two very similar
flaviviruses in a larger window after initial infection than currently possible.
My current projects focus on understanding the molecular mechanisms of the balance
between protective and pathogenic T cell responses to
flaviviruses, including Dengue and Zika.