Sentences with phrase «between gene variants»

Although recent research has demonstrated that the allele × environment strategy is promising for detecting individual vulnerability to environmental risk, reported associations between gene variants and complex behaviors are in general weak.

Interestingly, the association between the gene variants of the OTR and AVPR1A and the quality of pair bonding is also detected in the partner's perception of marital satisfaction (Walum et al., 2008, 2012).

Mekile says she plans to use her award to establish a link between gene variants in patients and autism - like neurological disorders.

«Here we show that the bitterness of sampled ethanol varies with genetic differences in bitter taste receptor genes, which suggests a likely mechanism to explain previously reported relationships between these gene variants and alcohol intake.»

A large - scale genetic study published in The Lancet in 2012 found no relationship between gene variants that increased HDL and the likelihood of heart attack (though this research did not evaluate the SCARB1 variants).

However, the team found no association between the gene variant and diabetes, even though the two conditions normally go hand in hand.

Not exact matches

FADS1 FADS2 gene variants modify the association between fish intake and the docosahexaenoic acid proportions in human milk

«Gene variant activity is surprisingly variable between tissues.»

To identify gene variants associated with musical aptitude, Irma Järvelä at the University of Helsinki, Finland, and colleagues analysed the genomes of 767 people assessed for their ability to detect small differences between the pitch and duration of a sound, and musical pattern.

In many cases, the activity of particular genes was tied to a single genetic variant, with strong differences in frequency between European and African populations.

Meanwhile, a collaboration between David Schaffer of the University of California at Berkeley and pulmonologist Joseph Zabner of the University of Iowa has scientists excited about the possibility of curing cystic fibrosis using another variant of the virus to deliver healthy genes to lung tissue.

The Penn study did not examine why no statistically significant relationships between smoking, the gene variants under investigation, and earlier menopause were observed in African Americans.

A study of people from an isolated village in the Netherlands reveals a link between rare variants in the gene NKPD1 and depressive symptoms.

Their analysis — which used DNA data from a Neandertal woman from the Altai Mountains in Siberia (SN: 1/25/14, p. 17) and 112,338 present - day British people — confirmed some links between Neandertal heritage and human diseases made by previous studies (SN: 3/5/16, p. 18), but didn't find evidence that Neandertal gene variants contribute to obesity.

A study of the interplay between peer drinking and the functional polymorphism rs1229984 in the alcohol dehydrogenase 1B gene (ADH1B) in the development of adolescent drinking milestones has found that peer drinking reduces the protective effects of an ADH1B variant.

The new study focused on 40 cognitively healthy older adults between the ages of 65 and 75 who are carriers of a gene variant (APOE e4) that is known to contribute to the risk of developing late - onset Alzheimer's disease.

«Since our study only looked at common gene variants, the total genetic overlap between the disorders is likely higher,» explained Naomi Wray, Ph.D., University of Queensland, Brisbane, Australia, who co-led the multi-site study by the Cross Disorders Group of the Psychiatric Genomics Consortium (PGC), which is supported by the NIH's National Institute of Mental Health (NIMH).

The Vienna research group, together with international cooperation partners, have demonstrated that there are interactions between stressful life events and certain risk gene variants that subsequently change the volume of the hippocampus forever.

A decade ago, they also identified a relationship between ALS and excess iron accumulation when they found that 30 percent of ALS patients in their clinic carried a variant of a gene known as HFE that is associated with iron overload disease.

Engelhardt's group was responsible for mapping associations between genetic variants and gene expression levels on different chromosomes, a connection known as «trans - expression quantitative trait loci (trans - eQTLS).»

«Surprisingly, when we looked for shared gene variants that might help explain part of the link between migraine and heart disease, we found no shared gene variations between migraine with aura and heart disease,» said study author Aarno Palotie, MD, of the Broad Institute of MIT and Harvard.

Recent studies have found elevated levels of this protein in post-mortem brain samples of patients with MS.. In this latest work, investigators compared the frequencies of «more active» and «less active» variants of the DNA sequences that control expression of the galanin gene between healthy controls and MS patients.

The existence of so many rare variants complicates efforts to study the relationship between genes and health.

To probe the link between gene and virus, neuroscientist HowardFederoff, of the University of Rochester School of Medicine, and his colleagues created mouse - cell cultures that expressed either theAPOE - e4 gene or another variant (APOE - e2 or APOE - e3), then infected the cells with herpes.

About 30 years ago, scientists found a link between MS and certain variants in the major histocompatibility complex (MHC), a cluster of genes that help the immune system distinguish between the body's own proteins and those of microbial invaders.

The researchers also found that these copy number variants occurred more frequently in genes involved in the function of synapses, the connections between brain cells that transmit chemical messages.

These mutations varied tremendously between populations, which counters a popular view that many of the differences between populations arose by chance or were genetic variants that hitchhiked along with other genes that improved reproductive success, says biological anthropologist Henry Harpending of the University of Utah, Salt Lake City, and co-author of another study of accelerated evolution.

Joshua - Tor's lab continues to work on Argonaute, which has eight structural variants in the human system alone and whose ability to fine - tune the output of our genes can mean the difference between health and sickness, even life and death.

MC1R variants affect the expression of melanocortin and melanogenic genes and the association between melanocortin genes and coloration.

No association was found between the genetic risk score and lifestyle factors and testing confirmed that only the abdominal adiposity effects of the identified gene variants were associated with cardiometabolic risk.

They revealed a number of genes associated with the timing of reproduction, and the genetic variants associated with spring or autumn spawning were found to be largely shared between geographically distant populations.

Reporting the first association between genetic variants in the human steroid 5a - reductase type II (encoded by the SRD5A2 gene) and prostate cancer in 1999.

A new study, led by Juha Kere (KI / SciLifeLab), has uncovered a link between a variant of the NCAN gene and developmental dyslexia.

This revealed that both Satellite and Faeder males carry a «supergene» which is not a gene with superpower but a cluster of about 90 genes kept together by a chromosomal inversion which means that there is no genetic exchange between the three different variants.

However, when we extracted gene expression levels from the brain transcriptome data following the methodology in Carneiro et al. [29], we found that levels of nucleotide diversity and the proportion of low frequency variants between lowly (bottom 5 %) and highly (top 5 %) expressed genes in our dataset (Table S7) were not significantly different in most comparisons (with the exception of π in O. c. cuniculus) nor did they consistently differ in the expected direction when assuming higher error rates in lowly expressed genes.

This network funds pilot studies to expedite collaboration between the two groups, conduct model organism - based functional studies of disease gene variants, and develop new therapeutic strategies using model organisms.

Duke University and other researchers have noted a strong association between development of AMD and presence of a variant of a gene known as complement factor H (CFH).

Importantly, the new process relies on strategically positioning the gene encoding the capsid variants on the DNA strand between two short sequences of DNA, known as lox sites.

It has recently been shown that individuals with variants of the MET gene show differential patterns of resting - state functional connectivity, such that differences between ASD and controls were moderated by genotype (Rudie et al., 2012).

The results from this study also revealed an association between the presence of XMRV and patients known to be homozygous for the R462Q variant of RNAse L, a gene previously linked to the hereditary prostate cancer 1 locus [4].

Some reasons for this relatively low yield include unappreciated phenotypic heterogeneity; locus heterogeneity; somatic and germline mosaicism; variants of uncertain functional significance; technically inaccessible areas of the genome; incorrect mode of inheritance investigated; and inadequate communication between clinicians and basic scientists with knowledge of particular genes, proteins, or biological systems.

Might mating between an ancient human and a Neanderthal - perhaps occurring in only a single instance - have introduced a gene variant into the human population that enhanced human brain function?

Genome - wide association studies use «genechip» technology to identify genetic variants (single gene polymorphisms or «SNPs») that could explain differences in health between individuals.

Is there any relationship between Hashimoto's nutrient deficiencies and being hetrozygous or homozygous for the MTHFR gene variant?

In human populations, genome - wide association studies have revealed associations between variants of the circadian clock — related gene Mntr1b, which encodes melatonin receptor 1B, fasting glucose concentrations, and the risk of type 2 diabetes (12 — 14).

That particular high risk variant is not seen in Golden Retrievers, but the association between the genes of the immune system and hypothyroidism is incompletely investigated in Golden Retrievers.

Here, we review recent work that has demonstrated a robust cross-national correlation between the relative frequency of variants in these genes and the relative degree of individualism — collectivism in each population, suggesting that collectivism may have developed and persisted in populations with a high proportion of putative social sensitivity alleles because it was more compatible with such groups.

Support for the association between the rare functional variant I425V of the serotonin transporter gene and susceptibility to obsessive compulsive disorder