Clare Wilson reports research on the relationship
between genes for proteins that «carry bad cholesterol» and longevity (6 September, p...
Not exact matches
Perhaps the most significant distinction
between evolution and ID / creationism is evolution's ability to explain poor design features, e.g. male nip - ples, the recurrent laryngeal nerve, the presence / location of endogenous retroviruses, and (one of my personal favorites) the presence of a defunct
gene for egg yolk
protein in our placental mammal genomes.
Building the knowledge base requires humans to teach computers key concepts from curated articles; with modest online training, anyone who reads English can scan research papers
for key terms — names of
genes,
proteins, diseases, and drugs — and use online marking tools to document relationships
between them (
for example, drug X treats disease Y).
Sequencing the genome of one such organism, King and her colleagues found
genes that code
for pieces of the same
proteins used
for the binding of cells and communication
between cells in animals — functions that would be unexpected in such an organism.
Of particular interest are the emerging techniques
for genomics and proteomics, which allow profiles of
gene expression and
protein synthesis to be produced and comparisons to be made
between normal and abnormal cells, as well as
between cells before and after exposure to medicines or toxic chemicals.
They used another database listing interactions
between different
proteins, to narrow down the list of
genes and account
for interactions
between them.
Genes may carry information for building proteins, but a host of other factors, including the DNA between genes that doesn't encode proteins, tells them when to make their prot
Genes may carry information
for building
proteins, but a host of other factors, including the DNA
between genes that doesn't encode proteins, tells them when to make their prot
genes that doesn't encode
proteins, tells them when to make their
proteins.
And large, genome - wide studies searching
for genetic underpinnings
for more common diseases, such as lung cancer or autism, have pointed to the nether regions of the genome
between the
protein - producing
genes — areas that were often thought to contain «junk» DNA that was not part of the pantheon of known
genes.
Hong - Zhong Zhang and colleagues at the University of California at San Francisco deciphered the signaling system
between a
protein in a resistant staph cell that keeps watch
for beta - lactams and a second
protein that it tells to turn on the
gene for beta - lactamase when the drugs are present.
RNA acts as the intermediary
between genes and
proteins, but the function of pieces of RNA that do not code
for protein has, historically, been less clear.
These are sequences produced in the lab from the RNA that is the intermediate step
between gene and the
protein it codes
for.
Wanting to understand the relationship
between CMG2 and collagen VI, the team developed double - knockout mice in which the
genes for both
proteins — CMG2 and collagen VI — had been deleted.
Thirty years ago, geneticist Mary - Claire King and biochemist Allan Wilson proposed that changes in how
genes are regulated, rather than in the
proteins they code
for, could explain important differences
between chimps and humans (Science, 11 April 1975, p. 107).
The Arizona researchers studied whether cage conditions affect mice with one copy of a
gene called fibulin - 4, a member of a family of
genes believed to code
for proteins that stabilize the connective tissue found
between cells in arteries and other blood vessels.
The
gene manufactures a
protein that binds monoamines into packages, called vesicles,
for transportation
between neurons.
When zinc hooks up with a
gene - controlling
protein, it forms «zinc finger
proteins» - so called because they can poke into the tight groove
between the two strands of DNA and touch the sequence they're made
for.
Viruses that store their information in RNA - genetic material that is the middle - man
between our
genes and the
proteins they code
for - evolved alongside the backboned - animals the viruses infect, according to internationals scientists, including Read more about Ancient origins of viruses discovered - Scimex
Simply determining the DNA sequence of the genome would be sufficient
for comparison with the genomes of other species to identify similarities
between genes or
protein domains among species.
Using an array of techniques, including RNA sequencing and targeted
gene expression profiling, the researchers searched
for links
between gene activity and
protein production in these tumors and the clinical outcomes of patients.
Their objective is to map the interactions among the 65
proteins those
genes code
for and chart the networks
between proteins, like drawing constellations out of stars in the sky.
Ebstein anomaly is within the diverse spectrum of cardiac morphologies triggered by a sarcomere
protein gene defect.Our study provides evidence
for a link
between structural
proteins, cardiomyopathy, and congenital heart malformations (Postma et al., 2011).
For example, it is used to identify correlations
between gene sequences and diseases, to predict
protein structures from amino acid sequences, to aid in the design of novel drugs, and to tailor treatments to individual patients based on their DNA sequences (pharmacogenomics).
The only clue indicating that differences in
gene expression level are not the reason
for the observed correlation
between the recombination rate and the size of introns is that we do not see a comparable pattern when examining the size of exons, the number of exons per
gene, and the overall size of
proteins.
Some reasons
for this relatively low yield include unappreciated phenotypic heterogeneity; locus heterogeneity; somatic and germline mosaicism; variants of uncertain functional significance; technically inaccessible areas of the genome; incorrect mode of inheritance investigated; and inadequate communication
between clinicians and basic scientists with knowledge of particular
genes,
proteins, or biological systems.
My lower ability GCSE students struggled distinguishing
between genes «being» the
protein and
genes «coding»
for the
protein.
A prominent example of the dual inheritance theory is the culture —
gene coevolution
between cattle milk
protein genes and human lactase
genes (Beja - Pereira et al. 2003), whereby the cultural propensity
for milk consumption in humans has led to genetic selection
for milk
protein genes in cattle and
gene encoding lactase in humans.