Not exact matches
«Scientists build better way to decode the genome: New computer algorithm deciphers DNA's most well - kept secrets; may help
find the links
between genes and disease.»
This study
found that the interaction
between these genomes and the implications on energy production is strong enough that the mitochondrial genome can alter which version of a
gene is present in the nuclear genome.
This
finding came as a surprise since it was assumed that as a consequence of the evolutionary divergence
between human and other animal viruses, the
genes that code for LANA could not be switched.
A large - scale genetic study published in The Lancet in 2012
found no relationship
between gene variants that increased HDL and the likelihood of heart attack (though this research did not evaluate the SCARB1 variants).
«It is an intriguing question as to how this Enterococcus strain acquired a botulinum neurotoxin
gene cluster, what benefit it brings to this bacterium, and further work is required to explore the implications of our important
finding with regard to the possibility of its transfer
between bacteria.
When researchers sequenced the sponge's genome in 2010, they
found genes that help individual cells cooperate as a group: how to divide, send signals to one another, and distinguish
between friends and outsiders.
The study
found that in the 18th and 19th centuries, about four to 18 per cent of the variation
between individuals in lifespan, family size and ages at first and last birth was influenced by
genes, while the rest of the variation was driven by differences in various aspects of their environment.
Dr Luis Pedro Coelho, corresponding author of the study, commented: «We
found many similarities
between the
gene content of the human and dog gut microbiomes.
Previous research has
found a link
between the AKT1
gene and people who have gone on to develop psychosis.
Sequencing the genome of one such organism, King and her colleagues
found genes that code for pieces of the same proteins used for the binding of cells and communication
between cells in animals — functions that would be unexpected in such an organism.
«It is exciting to
find a correlation
between brain circuitry and
gene expression by combining high quality data from these two large - scale projects,» says David Van Essen, Ph.D., professor at Washington University in St. Louis and a leader of the Human Connectome Project.
It
found that
genes associated with depression are involved in brain cell development, and that there was overlap
between these genetic regions and those linked to schizophrenia and other mental illnesses.
High in the Cederberg Mountains of South Africa grows a bristly shrub that embodies the tug - of - war taking place
between industrialized and developing nations over the value of genetic resources — the
genes found in plant, animal or microbial cells used for research as well as in commercial products, such as enhanced seeds and naturally derived cosmetics and pharmaceuticals.
The researchers also looked at the expression of a
gene involved in the control of wing development, and
found similarity
between the lab - induced supersoldiers and the natural ones.
Since the publication of the human genome sequence in 2001, scientists have
found that the so - called junk DNA that lies
between genes actually carries out many important functions.
In unpublished research, Cagan (now at the Wellcome Trust Sanger Institute in Hinxton, England)
found that
genes involved in helping neural crest cells migrate differed
between the tame and wild animals (SN: 6/13/15, p. 11).
Here's how DNA and connectivity relate: When movements and mating across blocks of territory are taking place smoothly,
gene flow is unrestricted, and scientists don't
find a difference in DNA
between the members of a species or subspecies.
The investigators also
found that the key difference
between the two groups lies in the
genes involved in production of the bacterium's outer coat, the primary region that interacts with the human immune system.
They
found that the Neanderthal genome shows more similarity with non-African modern humans throughout Europe and Asia than with African modern humans, suggesting that the
gene flow
between us and Neanderthals most likely occurred outside Africa as humans were en route to Europe, Asia, and New Guinea.
However, the team
found no association
between the
gene variant and diabetes, even though the two conditions normally go hand in hand.
«We
found that as more «mixing» occurs
between local dust and that which comes from far off, the lower the contribution of the imported antibiotic resistance
genes.»
Some scientists
found that the fields make cells divide more rapidly or produce abnormally large quantities of messenger RNAs — molecules which are the intermediate step
between genes and proteins.
The
gene expression similarities
between this common condition and the current
findings in late - stage RP suggest that the canine RP models could serve as stand - ins to evaluate the effectiveness of pharmaceutical interventions that target innate immunity pathways in AMD
To
find out more about the differences
between naive and primed pluripotent cells, the UW researchers first compared their
gene expression profiles.
He
found that the
genes together regulate the interaction
between the two mutually exclusive behaviors, sleep and feeding, kicking in to suppress sleep when a fly is hungry.
The largest ever genetic study of mosquitoes reveals the movement of insecticide resistance
between different regions of Africa and
finds several rapidly evolving insecticide resistance
genes.
Looking for a mechanism, researchers
found remnants of
genes from past infections, sandwiched
between odd, repeated bacterial DNA sequences — the «clustered regularly interspaced short palindromic repeats» that give CRISPR its name.
They
found that the chicks formed AERs and sprouted limbs wherever there was a boundary
between cells that expressed the transplanted R - fng
genes and cells that weren't infected.
The researchers
found that there appeared to be a tipping point, where a patient would go from having lots of individual mutations, but no cancer, to a situation where large pieces of genetic information were being transferred not just
between genes but
between chromosomes.
Researchers
found that language differences
between cultures create significant barriers to the diffusion of folk tales, and that these barriers are stronger than those for the exchange of
genes
Their analysis — which used DNA data from a Neandertal woman from the Altai Mountains in Siberia (SN: 1/25/14, p. 17) and 112,338 present - day British people — confirmed some links
between Neandertal heritage and human diseases made by previous studies (SN: 3/5/16, p. 18), but didn't
find evidence that Neandertal
gene variants contribute to obesity.
Despite differences in brain size, the researchers
found striking similarities
between primate species of
gene expression in 16 regions of the brain — even in the prefrontal cortex, the seat of higher order learning that most distinguishes humans from other apes.
«It is possible that uniform relationships among white and African American women were not
found due to other factors associated with race that modify the interaction
between smoking and
genes,» said Butts.
When they compared this with the genomes of five modern humans, they
found that people of non-African origin had inherited
between 1 and 4 per cent of their
genes from Neanderthals.
A study of the interplay
between peer drinking and the functional polymorphism rs1229984 in the alcohol dehydrogenase 1B
gene (ADH1B) in the development of adolescent drinking milestones has
found that peer drinking reduces the protective effects of an ADH1B variant.
Links
between genetics and mental illness led to several major discoveries this year: Researchers at Myriad Genetics in Salt Lake City reported
finding a
gene related to depression, and researchers at the University of California at San Diego
found a flawed
gene linked to manic depression.
Both Tsigelny and Kurzrock agreed that this
finding is an excellent example of the power of collaboration
between SDSC and the Moores Cancer Center, and that such modeling needed to be studied across tumors and with multiple different
genes involved in cancer.
Booth says these
findings may suggest a link
between the
genes responsible for exercise motivation and the
genes responsible for mental development.
GWAS meta - analysis identified an association
between the
gene TLR1 and H pylori seroprevalence, «a
finding that requires replication in non-white populations,» the authors write.
While the authors
found evidence for
gene flow
between sampled groups, the ancestral population of Aboriginal Australians started to become structured around 31» 000 years ago thus creating the genetic diversity observed today.
The study, conducted
between November 2013 and March 2015, screened patients at admission for the tcdB
gene through a rectal swab and those
found to be C. difficile carriers were put under contact isolation precautions during their hospitalization.
Surprisingly, they
found that although the patterns of
gene expression — as shown by the RNA sequencing — differed
between the hepatocellular carcinomas and the liver cancers with biliary phenotype and depended on the histological type, the overall pattern of mutations in the cells was actually similar
between the tumors — of either type — that had emerged in patients who had had infections with either hepatitis C or B, and were different in patients without such infections.
This is uncommon in mushrooms: it is the first time
genes for a compound that is not necessary for the fungi's survival — called a secondary metabolite — have been
found moving
between mushroom lineages.
Evolutionary tree diagrams, which take into account mutation rates, suggest that the few F promoters
found in mice today are remnants of L1
genes that were active
between 5 and 10 million years ago.
«These
genes are
found in
between 6 and 14 % of men» said Alexandre Zlotta, «This makes it one of, if not the, most common
genes yet
found to be associated with aggressive prostate cancer.
They built a new software tool called MIxT (Matched Interactions across Tissues) that uses computational and statistical methods to
find and investigate links
between gene expression in different body tissues.
«BinoX works so well thanks to the high density of the FunCoup networks, which makes it possible to
find many functional network links
between gene sets, even if they have no shared
genes.
There are about 10 million of them in the human genome (often
found in the DNA
between genes), and most have no effect on health or development.
According to Dr. Raül Andero Galí, lead researcher in this study, «Once we discovered the relationship
between the Ppm1f
gene and different psychological disorders after exposure to traumatic stress, we wanted to
find an effective drug to prevent these changes and its negative consequences on the brain.»
A decade ago, they also identified a relationship
between ALS and excess iron accumulation when they
found that 30 percent of ALS patients in their clinic carried a variant of a
gene known as HFE that is associated with iron overload disease.