In the Dec. 1 issue of Science, the team from the MGH Center for Systems Biology describes a «crosstalk»
between lung tumors and bone marrow, which leads to the generation of a type of immune cell that travels to the tumor and promotes its progression.
«Our findings indicate the existence of long - distance interactions
between lung tumors and bones: lung tumors remotely activate osteoblasts, and those bone cells, in turn, shape immunity by supplying tumors with cancer - promoting neutrophils,» says Pittet, who is an associate professor of Radiology at Harvard Medical School.
«Communication
between lung tumors, bones contributes to tumor progression: Study identifying interaction among tumor cells, bone marrow and immune cells opens new avenue for immunotherapy.»
Not exact matches
«High concordance
between EGFR mutations from circulating - free
tumor DNA and
tumor tissue in non-small cell
lung cancer.»
Researchers identified 1,661 differentially expressed gene features
between tumors and airways compared with normal
lung tissue.
Cancer Institute research highlights include innovative studies to develop individualized approaches for treatment and prevention of
lung cancer; collaboration
between medical and materials science researchers to develop treatments for various types of leukemia using nanotechnology to target only cancer cells; and development of novel therapeutics to treat metastatic melanoma using an approach that regulates the processes leading to
tumor development.
In addition to genetic differences
between lung cancer
tumors in people who smoke or have smoked versus those who never have, researchers are also finding genetic differences in the people themselves.
Amy's own childhood, as the descendant of a famous doctor herself, was fraught with dysfunction that led her to suppress the distress of the first 18 years of her life that finally exploded as a cancerous
tumor wedged
between her heart and
lung and an autoimmune disease that caused critical issues with her treatment.
She X-rayed him and saw «a good - sized round mass in -
between his heart and his
lungs which could be the worms or could also be a
tumor.»
A Comparison
between Three - Dimensional Conformal Radiotherapy, Intensity - Modulated Radiotherapy, and Volumetric - Modulated Arc Therapy Techniques for Stereotactic Body Radiotherapy of
Lung Tumors