By restoring the «good» bacteria in the mice, the miscommunication
between macrophages and neurons is reversed, showing that the dialogue between the macrophages and nervous system is adaptable to the changes in the bacterial environment.
We will combine methods from the fields of immunology, developmental biology and angiogenesis to understand in vivo the development and lineage - specific function (s) of resident macrophages, thereby opening new venues of research into the interaction
between macrophages and endothelial cells in response to tissue damage.
The study «connects the dots in a very detailed way
between macrophages and the hormone receptor signaling pathway,» says prostate cancer researcher Charles Sawyers of the University of California, Los Angeles.
Sieweke's team will next focus their research efforts on the relationships
between macrophages, sperm, and testosterone production, which may yield innovative treatments for certain kinds of male infertility.
By changing the macrophages» metabolism, we actually set up a «glucose competition»
between the macrophages and the tumor's blood vessels.
Not exact matches
This is due to a randomised trial with 215 eligible patients performed
between 1989 and 1991, which showed a significant increase in severe thrombocytopenia, severe anemia, pulmonary complications and toxic deaths when granulocyte -
macrophage CSFs (GM - CSFs) were used during concurrent chemo - radiotherapy.
Macrophages squeeze in
between heart muscle cells, called cardiomyocytes.
The research team, Heller says, has already begun experiments to further explore the implications of these results, which include looking at differences in this pathway
between cells taken from allergic and healthy individuals, and testing the efficacy of an inhalable drug that mimics the function of GRB1 and p70S6K to shut off the development of M2
macrophages in the lungs of mice.
In recent years Lin's team devised a method to produce particles that are all
between 20 and 40 nanometers in size (a nanometer is one - billionth of a meter), a range best able to elude
macrophages.
A balance
between the activation of the inflammatory
macrophages and suppression of the anti-inflammatory
macrophages in the kidney may play a pivotal role in kidney stone formation.
The current study found that mice meant to serve as a model of ischemic human heart failure (weaker blood flow after a heart attack) had higher levels of activated, pro-inflammatory
macrophages, monocytes, dendritic cells and T cells trafficking
between their hearts and spleens than did control mice with healthy hearts.
The genomes of the aged
macrophages expressed more genes that hinder a group of molecules that spread signals
between nerve cells, called catecholamines.
The close relationship
between adipocyte size and the abundance of
macrophages in adipose tissue suggests that the influence of adipocyte size on adipocyte function may be conveyed through a paracrine pathway involving adipose tissue
macrophages.
The strong relationship
between adipose tissue
macrophage content and indicators of adiposity provides a mechanism for the increased adipose tissue production of proinflammatory molecules and acute - phase proteins associated with obesity.
Our findings suggest that data obtained from aP2 transgenics will need to be carefully analyzed to distinguish
between effects occurring primarily in adipocytes or
macrophages.
The cardiovascular
macrophage: a missing link
between gut microbiota and cardiovascular diseases?
A detailed comparison of gene expression signatures
between ETP ALL tumors and and normal human hematopoietic progenitor cells revealed a somewhat surprising finding: ETP - ALL expression patterns were less consistent with early T - cell precursors, as might have been expected, but more similar to the expression profile of normal hematopoietic stem cells and granulocyte
macrophage precursors.
Close to such depigmented RPE cells, highly pigmented
macrophages identified by CD68 staining were located
between Bruch's membrane and the RPE and in the subretinal space or within the choroid.The total number of lipofuscin granules was counted in the cytoplasm of RPE cells from untreated and treated monkeys.
Coupling
between Myogenesis and Angiogenesis during Skeletal Muscle Regeneration Is Stimulated by Restorative
Macrophages
It has been observed for nearly 80 years that Bps can change colony morphology, and recent studies have shown an association
between morphotypes and specificity for body compartments, ability to adhere and penetrate epithelial cells or
macrophages, and expression of virulence factors.
Macrophages (green) squeeze in
between heart cells (red) in an area of the heart called the AV node, as seen in this reconstruction of a human AV node.
Whitehead Institute researchers have uncovered a novel association
between two fungal recognition receptors on the surface of certain immune cells, called
macrophages.
They'll be making comparisons
between the microRNA profiles within
macrophages isolated from human and dog osteosarcoma samples.