Scientists believe there is a link
between microcephaly and Zika, and a growing body of evidence supports this claim.
While a link
between microcephaly and Zika infections has not been proven, there's evidence to suggest the virus may be passed from mothers to their babies via the placenta.
Not exact matches
It covered all babies born with
microcephaly delivered in eight public hospitals in Brazil's north - eastern Pernambuco State
between January 15 and May 2 this year.
The connection
between Zika and
microcephaly first came to light last fall in Brazil, which has now confirmed more than 1,800 cases of
microcephaly that it considers to be related to Zika infection in the mothers.
As we report in a collection of stories, much remains unclear, including the relationship
between Zika infection and
microcephaly and how best to combat the mosquitoes that spread the disease.
Last year, however, concerns about the virus skyrocketed following the link
between Zika virus infection with
microcephaly in Brazil.
«We've been seeing growing evidence of the association
between Zika and congenital central nervous system malformations, not just
microcephaly, since the first cases were picked up,» says Wim Van Bortel, senior expert on vector - borne diseases at the European Centre for Disease Prevention and Control in Solna, Sweden.
While the mouse study does not prove a direct connection
between Zika infection and
microcephaly, Rossi said, it does underscore the urgent need for effective animal models to further study the course of disease and its transmission.
He continues, «There is a clear temporal association
between the increased reporting of cases of
microcephaly and of GBS and the Zika virus outbreak.
An association
between Zika infections during pregnancy and the birth of babies with
microcephaly (a birth defect in which an infant's brain does not develop properly resulting in a smaller than normal head) was first suggested by Brazilian physicians in August 2015, and in November
microcephaly cases potentially associated with Zika started to be recorded; three months later WHO made its announcement.
Frieden, who is the second - longest serving CDC director in the agency's history, says his years at the helm were marked with successes that include affirming the link
between Zika virus and
microcephaly, helping beat back Ebola and supporting programs that promoted a drop in U.S. teen pregnancy numbers.
As evidence grew for a causal link
between Zika infection and
microcephaly and other serious congenital anomalies (1), the World Health Organization (WHO) declared the Latin American Zika epidemic a public health emergency of international concern in February 2016 (2).
That state has seen at least 487
microcephaly cases so far this year, compared with an average of 10 cases annually
between 2010 and 2014.
While this study does not prove the direct link
between Zika and
microcephaly, it does pinpoint where the virus may be doing the most damage.
Chan noted that there was «a particularly strong association in time and in space»
between the arrival of the virus and the detection of
microcephaly and other neurological disorders.
Increasingly strong links
between the spread of Zika virus and
microcephaly in newborns led the World Health Organization (WHO) today to declare a Public Health Emergency of International Concern.
These findings may correlate with disrupted brain development, but direct evidence for a link
between Zika virus and
microcephaly is more likely to come from clinical studies, the researchers say.
Treating the link
between Zika virus and diseases like
microcephaly as «guilty unless proven innocent» may help to aid public health responses.
In 2015, the Zika virus began spreading throughout the Americas and a potential link was seen
between the virus and a significant increase in cases of fetal
microcephaly, as well as other neurologic abnormalities.
«Likely biological link found
between Zika virus,
microcephaly: Discovery with lab - grown stem cells could be used to identify potential therapies.»
«Many unanswered questions remain about the links
between Zika virus disease,
microcephaly and Guillain — Barré syndrome,» noted Etienne.
Then, in late November, the Brazilian government said it believed there was a link
between Zika and
microcephaly — and sales went through the roof.
But Peter Hotez, dean of the National School of Tropical Medicine at Baylor College of Medicine, said its findings offer «potentially important» new information about the link
between Zika and
microcephaly.
Strengthening the link
between Zika virus and
microcephaly, scientists at UC San Francisco have discovered that a protein the virus uses to infect skin cells and cause a rash is present also in stem cells of the developing human brain and retina.
«In addition to
microcephaly, infection with Zika virus in adults can lead to destruction of myelin, a mixture of proteins and fatty substances that insulate nerves to speed electrical communication
between neurons, a condition called Guillain - Barre syndrome.»
CDC director Tom Frieden said Friday that scientists are confident that there is an association
between the Zika virus and
microcephaly.
Researchers said studies are still needed to definitively prove the link
between Zika and
microcephaly.
There is a causal link
between Zika infection and at least two serious diseases:
microcephaly and Guillain - Barré Syndrome (GBS).
However, this is precisely the type of question that researchers are now seeking to answer with the additional funding and resource made available following the WHO statement yesterday declaring the potential link
between Zika virus and
microcephaly as a public health emergency of internal concern.»
The birth prevalence of neonatal
microcephaly and other central nervous system malformations greatly increased
between 2015 and mid-2016 in Brazil.1 - 3 Several reports1,2,4 - 6 suggested an association
between these findings and Zika virus (ZIKV) infection during outbreaks in Brazil and French Polynesia.
If Zika is the cause of
microcephaly (and at the moment this looks increasingly likely), then a more subtle interaction
between virus, patient and environment is involved, rather than some new property arising within the virus due to mutation.
The association
between Zika virus infection and
microcephaly, however, has not been precisely quantified.
This could make it harder to understand the potential relationship
between Zika,
microcephaly and other neurological complications in South America and other regions.
Based on a newly published systematic review of current research, WHO has reaffirmed its position that Zika virus infection during pregnancy is a cause of congenital brain abnormalities, including
microcephaly, and refined its position on the relationship
between Zika virus infection and Guillain - Barré syndrome, stating that Zika virus infection is a trigger of Guillain - Barré syndrome.