Sentences with phrase «between mouse and human»

INFRAFRONTIER, as project partner, leads the Work Package 7 - «Use case: PhenoBridge - crossing the species bridge between mouse and human».

This work package is aimed at harmonising ontological descriptions of phenotypes in mouse and human, consequently improving the links between mouse and human data.

This inability to reprogram human NSCs with OCT3 / 4 alone might indicate possible differences between mouse and human NSCs.

Being able to go back and forth between the mouse and human genomes so easily has also made it much simpler and quicker to target related human genes that could be candidates for drug development.

Of the 22 patients whose tumors successfully grafted, six died before data from the mice were available, but in 13 of the remaining 16 cases, there was a positive correlation between mouse and human results.2 In a second study, performed in collaboration with Manuel Hidalgo of the Spanish National Cancer Research Center, the team found that 6 of 13 patients with advanced solid tumors who were treated based on results from personalized PDX mice had partial tumor remissions, even in cases where genetic sequencing of the tumor showed no actionable mutations.3

Raymond White, a human genetics researcher at UCSF's Ernest Gallo Clinic and Research Center in Emeryville, said the points of similarity between mouse and human genomes were vitally important — they represent bits of genetic material that have survived, intact, over 75 million years of evolution.

Two companion studies further illustrate differences between mouse and human.

The high degree of similarity between the mouse and human genomes is demonstrated through analysis of the sequence of mouse chromosome 16 (Mmu 16), which was obtained as part of a whole - genome shotgun assembly of the mouse genome.

«This is primarily because of the difference between the mouse and human immune systems.»

This consortium selected 44 separate sections of the genome that included regions of high to low gene density and high to low similarity between mouse and human.

Scientists aren't always thinking about the genetic differences between mice and humans because they're focused elsewhere.

By combining the pieces in one way or another, we would obtain very different circuits (as happens between mice and humans) although the basic mechanisms governing the operation are based on the same methods and available resources.

The team also discovered similar signatures of depression between the mice and humans.

«The methods for achieving transplantation tolerance differ between mice and humans, but the mechanisms that maintain it are likely shared,» said Marisa Alegre, MD, PhD, professor of medicine at the University of Chicago and co-senior author on the study.

Daniel Hollern is an MSU doctoral student who co-authored a study that analyzed the relationship between mice and human breast cancer.

For example, investigators found that for the mouse immune system, metabolic processes and stress response, the activity of some genes varied between mice and humans, which echoes earlier research.

Building on years of mouse and gene regulation studies, they have developed a resource that can help scientists better understand how similarities and differences between mice and humans are written in their genomes.

«Given that the functional connectivity between the prefrontal cortex and amygdala is largely conserved between mice and humans,» said TSRI Graduate Student Wen - Chin Huang, the first author of the study, «we anticipate the therapeutic strategies suggested here may be relevant for individuals on the autism spectrum.»

The fundamental genetic similarity between mice and humans allows researchers to infer a human gene's function based on studies with laboratory mice.

«The motivation for this research was to assess how similar the two species are in terms of problem - solving and learning in order to improve the translation of research between mice and humans.

«Increased amyloid beta production is not seen in mouse neurons and could potentially explain some of the discrepancies between mice and humans regarding drug efficacy.

In rodents, ketogenic diets reduce reactive oxygen species in the brain34 and reduce central inflammation and reactive oxygen species in a model of multiple sclerosis.35 Two clinical papers have found that ketogenic diet feeding of 12 weeks to 6 months reduced signs of liver inflammation in obese patients with nonalcoholic fatty liver disease (in addition to improving various other physiological and biochemical variables).36, 37 Unfortunately, basic research into non-alcoholic fatty liver disease has been hampered by species differences between mice and humans in their hepatic reaction to ketogenic diets.38

Not exact matches

Recent collaborative work between UCR and Cedars - Sinai Medical Center in Los Angeles demonstrated that in animal models of human breast cancer, mice treated with 123B9 that was conjugated with paclitaxel had significantly fewer circulating cancer cells in the blood compared to mice that were not treated or even treated with paclitaxel alone.

Duke scientists have shown that it's possible to pick out key changes in the genetic code between chimpanzees and humans and then visualize their respective contributions to early brain development by using mouse embryos.

Even the new studies clashed somewhat: Unlike the UCSF study, the German research found no major differences between the overall microbiomes of twins with and without MS. Finally, mouse models of MS are not perfect mimics of the human disease, and mouse immune systems aren't identical to people's.

In addition, the researchers have quantified the preservation level of this gene expression between humans and mice.

«Both in humans and mice there is a correlation between altered gut microbiota composition and inflammaging, but the link between the two remains to be proven in humans» concludes Fransen.

It's hard to compare sugar doses between humans and mice, which expend more energy relative to body weight than humans.

This take on Michelangelo's famous Sistine Chapel image symbolizes the link between human pain patients and the mouse model: The lab - designed SPR inhibitor (in green), shown within the active pocket of SPR itself (in gray with its atomic structure in colored lines), is the «bridge» between the two species.

After a few days, the cultured papillae were transplanted between the dermis and epidermis of human skin that had been grafted onto the backs of mice.

Now, a new study in mice shows how a gene, called FOXP2, implicated in a language disorder may have changed between humans and chimps to make learning to speak possible — or at least a little easier.

«Our studies took us back and forth between human patients and our mouse model,» said Millar.

The new study — published October 18, 2016 in the journal Molecular Psychiatry — combined genetic analysis of more than 9,000 human psychiatric patients with brain imaging, electrophysiology, and pharmacological experiments in mutant mice to suggest that mutations in the gene DIXDC1 may act as a general risk factor for psychiatric disease by interfering with the way the brain regulates connections between neurons.

Human tumor tissue or cell lines can be coengrafted into these mouse models, providing a powerful tool for studying the interactions between human immune cells and human canHuman tumor tissue or cell lines can be coengrafted into these mouse models, providing a powerful tool for studying the interactions between human immune cells and human canhuman immune cells and human canhuman cancers.

«At a biochemical level, there is a lot of commonality between the molecular machinery in Drosophila and that in mice and humans,» said Dr. Ferguson.

«If you're looking for very specific molecular targets or pathways in the brain, and how drugs might act on them, the difference between human cells and mouse cells is significant.»

Work in germ - free mice shows providing the right human microbial communities can restore growth, likely by restoring the proper connections between growth hormone and insulinlike growth factor 1.

Soon, the mouse — which from a genetic point of view is nearly human — will join this ship: its genome is sought in another race between the publicly funded mouse genome sequencing project and Celera.

After conducting studies in both humans and mice, the researchers said this new schizophrenia risk gene, called C4, appears to be involved in eliminating the connections between neurons — a process called «synaptic pruning,» which, in humans, happens naturally in the teen years.

Though these findings have been obtained in mice, the scientists hypothesize that disrupted coordination between the development of the microglia and that of the brain contributes to an increased risk of such neurodevelopmental disorders as autism and schizophrenia in human beings.

The 1918 virus (r1918) activated many more mouse genes involved in the immune system than a modern human flu virus (Tx91) and two hybrids between a modern virus and the 1918 strain.

If you are studying the human link between impulsivity and addiction, you might try another test of impulsivity: The mouse gets a treat for pressing a bar when a light turns green — unless it immediately turns red.

Acknowledging the gap between experimental results in mice following direct injection of MVs into the amnion sac and human pathogenesis, the researchers nevertheless suggest that their findings «provide a novel insight into how GBS while simply sitting in the vagina can orchestrate events at the fetal membrane leading to premature birth.»

For chemicals that don't cause cancer, they obtain a safe dose for humans by applying uncertainty factors to account for differences between mice and men and among individual people.

Walford's new research is based on the fact that in mice and humans, the immune system malfunctions during aging, losing the ability to distinguish between healthy cells and invasive pathogens such as bacteria and viruses.

The current study found that mice meant to serve as a model of ischemic human heart failure (weaker blood flow after a heart attack) had higher levels of activated, pro-inflammatory macrophages, monocytes, dendritic cells and T cells trafficking between their hearts and spleens than did control mice with healthy hearts.

He thinks the final count for both human and mouse will be «between 30,000 and 40,000 genes.»

Body temperature differences of 1 °C to 3 °C found between the morning and the evening in humans and mice have therefore important implications.

The protein sequence of SATB2 is remarkably similar between frogs, mice and humans.

First, they drilled a 1 - millimeter hole into the tibia (in humans, the bone between the knee and the ankle) of anesthetized mice to simulate a bone break.