Extending their work to independent data, not used to originally identify the networks, Dr Tew and colleagues demonstrated a signature of disease - associated messages that could distinguish
between osteoarthritic and healthy cartilage in humans.
The correlation
between these two selection indexes (0.771 — 0.774) is sufficiently less than unity enabling the selection of dogs with different genetic propensity for laxity and for
osteoarthritic CHD changes in GSDs; this may also be applicable in other breeds.