Featured on the cover of Developmental Cell, a paper by OIST researchers revealed the mechanistic link
between photoreceptor cell degeneration and defects in protein transport.
Not exact matches
The second layer is made of bipolar
cells that act as a conduit
between the
photoreceptor and the third type of
cell, the ganglion, which transmits the light signals to the brain.
Both unmodified and genetically modified groups were found to have
cells that migrated and survived in two distinct locations: (i) as a separate, nearly continuous, subretinal layer lying
between the host RPE and
photoreceptors, and (ii) as individual
cells distributed throughout the neurosensory retina, especially within the inner retinal layers (Figure 5A).
iPS - RPE
cells were injected into the subretinal space
between the host RPE and
photoreceptor cells (B) A layer of iPS - RPE
cells in the subretinal space of the dystrophic RCS rat 20 hours following transplantation.
The retinal pigment epithelium (RPE) is a monolayer of
cells, residing at the back of the eye
between Bruch's membrane and the retina, which is essential for
photoreceptor function and survival.
The gene product's precise role is not currently understood but it is thought to anchor regulatory complexes at the
photoreceptor connecting cilium, which acts as a bridge
between the inner and outer segments of
photoreceptor cells [43] as well as having functions in disk morphogenesis [42] and in the structure of the ciliary axoneme [44].