Baseline variables were measured using established valid instruments and were used as covariates to adjust for differences
between randomisation groups in some of the analyses in the paper.
Not exact matches
We would have considered it reasonable to combine the results from both if there was little heterogeneity
between the study designs and the interaction
between the effect of intervention and the choice of
randomisation unit was considered to be unlikely.
In studies where there was
randomisation at the clinic level, all women may have been exposed to the same intervention, and contamination
between groups would thereby be reduced, but there may still have been a risk of response bias if outcomes were reported to staff providing care.
They analysed genetic variants with known effects on height and body mass index (BMI) from 119,000 individuals aged
between 40 and 70 in the UK Biobank — a database of biological information from half a million British adults — using a technique called mendelian
randomisation.
Using Mendelian
randomisation (MR), we sought to evaluate associations
between polyunsaturated (PUFA), monounsaturated (MUFA) and saturated FAs (SFAs) and CRC risk.
Here we apply a Mendelian
randomisation (MR) analysis to examine the potential causal relationship
between lipid traits and CRC risk.
We stratified
randomisation by site and maintained balance
between groups within each stratum using a minimisation method using computer - generated random numbers to give an equal chance of allocation to each group when groups within the stratum were balanced and an increased chance (0.667) of allocation to the smaller group when there was an imbalance within the stratum.69 The
randomisation service at Warwick Clinical Trials Unit generated the random allocation sequence and informed the FLNP co-ordinators of group allocation following recruitment of a family by the researchers.
Emily Stapley summarises a Mendelian
randomisation study that investigates associations
between the timing of menarche with depressive symptoms and depression in adolescence.