«We did not find evidence of genetic overlap
between schizophrenia risk and subcortical volume measures, either at the level of common variant genetic architecture or for single genetic markers.
Not exact matches
People who have a greater
risk of developing
schizophrenia are more likely to try cannabis, according to new research, which also found a causal link
between trying the drug and an increased
risk of the condition.
This suggests that the results were not wholly driven by differences in lifestyle factors or ethnicity
between the two groups, and may therefore point towards
schizophrenia's direct role in increasing
risk of diabetes.
A new study led by Wayne State University School of Medicine researcher Vaibhav Diwadkar, Ph.D. suggests that the brain network interactions
between regions that support attention are dysfunctional in children and adolescents at genetic
risk for developing
schizophrenia and bipolar disorder.
«Our results suggest that there are substantial differences
between specific antipsychotic agents and
between routes of administration concerning the
risk of rehospitalization and treatment failure among patients with
schizophrenia,» the article concludes.
After conducting studies in both humans and mice, the researchers said this new
schizophrenia risk gene, called C4, appears to be involved in eliminating the connections
between neurons — a process called «synaptic pruning,» which, in humans, happens naturally in the teen years.
«We've focused our lens on these
risks in a small population with a specific genetic subtype of
schizophrenia, where the connection
between birth factors and
risk of developing
schizophrenia is noticeably stronger.»
Though these findings have been obtained in mice, the scientists hypothesize that disrupted coordination
between the development of the microglia and that of the brain contributes to an increased
risk of such neurodevelopmental disorders as autism and
schizophrenia in human beings.
«Given the solid epidemiologic evidence supporting a link
between cannabis exposure during adolescence and
schizophrenia, we investigated whether the use of cannabis during early adolescence (by 16 years of age) is associated with variations in brain maturation as a function of genetic
risk for
schizophrenia,» said senior author Tomas Paus, MD, PhD, the Anne and Max Tanenbaum Professor and Chair in Population Neuroscience at Baycrest, University of Toronto, and the Dr. John and Consuela Phelan Scholar at Child Mind Institute, New York.
The relationship
between the heritable
risk for
schizophrenia and low intelligence (IQ) has not been clear.
A study by researchers at Columbia University's Mailman School of Public Health, Columbia University Medical Center (CUMC), New York State Psychiatric Institute and colleagues in Finland reports an association
between smoking during pregnancy and increased
risk for
schizophrenia in children.
«No link found
between subcortical brain volumes, genetic
risk for
schizophrenia: Proof - of - concept study provides roadmap for future research into possible associations
between brain volume measures, known genetic
risk factors.»
For a study published in the journal Biological Psychiatry, Ole Andreassen and colleagues compared genetic information from Neanderthals and modern humans and found an association
between markers of human evolution and genetic
risk for
schizophrenia.
Among other things his research group has studied the connection
between the paternal age at conception and the
risk of the child developing
schizophrenia.
Examples might be a manuscript that examines social - cognitive processes and their relevance to the etiology of depression, a manuscript that examines how the interaction
between two brain regions places people at
risk for anxiety disorders, or a manuscript that examines how cultural variables shape the experience or expression of
schizophrenia (of course, these are only three potential examples among hundreds).
«And we found that the high -
risk group and early, or first - episode,
schizophrenia group are somewhere in
between: It looks like these deficits begin even before they are diagnosed and treated.
It found substantial evidence of an association
between cannabis use and the
risk of motor vehicle crashes, as well as of lower birth weight after maternal use, more frequent chronic bronchitis episodes, and the development of
schizophrenia or other psychoses.
Together, our results show that rare, damaging variants contribute to the
risk of
schizophrenia both with and without intellectual disability and support an overlap of genetic
risk between schizophrenia and other neurodevelopmental disorders.