This study comes on the heels of a separate large - scale investigation that found no link
between statin use and the number of COPD exacerbations people experienced.
There were also no clear differences in the association
between statin use and outcomes in analyses stratified by age older or younger than 55, 60, 65, or 70 years, with very similar estimates from 7 trials (eTable 6 in the Supplement).14, 19,20,26,29,31,35 None of the trials that enrolled patients older than 75 years18, 20,22,23,27,29 reported results in this subgroup.
The randomised, blinded phase of the trial found no difference
between the statin and placebo groups for erectile dysfunction (1.86 % vs 2.14 % per year).
Researchers from the Charles E. Schmidt College of Medicine at Florida Atlantic University as well as Harvard Medical School address the possible but unproven link
between statins and diabetes, as well as the implications of prescription of statins for clinicians and their patients, in a commentary published in the American Journal of Medicine.
Earlier this year, I published an article by Suzy Cohen, R.Ph., (widely recognized as «America's most trusted pharmacist») in which she discussed the hidden link
between statins and diabetes.
Not exact matches
So the bottom line, according to the CTT estimates, is that for 5 percent of healthy people taking a
statin, the drug means the difference
between life and death, health or disability.
In that calculation, the number of people who would avoid a cardiovascular event is not 5 percent, as the review in Lancet estimated, but somewhere
between 1 and 2 percent — which means only 100 or at most 200 of every 10,000 healthy people taking a
statin would benefit.
All patients had Type 2 diabetes and had filled prescriptions for
statin medication to treat high cholesterol
between 2003 and 2004.
A link
between diabetes and
statins wasn't discovered until a 2008 analysis of almost 18,000 people published in the New England Journal of Medicine, which found that 216 people taking a placebo developed type 2 diabetes while 270 taking a
statin did.
Guidelines released in 2013 by the American Heart Association and the American College of Cardiology say that people
between the ages of 40 and 75 should take a
statin if their risk of cardiovascular disease is 7.5 percent or higher over the next 10 years.
«No association
between «bad cholesterol» and elderly deaths: Systematic review of studies of over 68,000 elderly people also raises questions about the benefits of
statin drug treatments.»
Until more epidemiological and basic research can be conducted to further parse out the associations
between PD, cholesterol and
statins, physicians and scientists should be cautious in promoting health benefits of
statins for PD without a good understanding of clinical evidence and potential biological mechanisms, Huang advises.
Previous studies on the relationship
between cholesterol drugs called
statins and the risk of Parkinson's disease have had inconsistent results.
Statin use is widespread in middle - aged and older individuals, who also have an increased risk of AMD; however, previous studies have shown very little correlation between regular statin use and improvements i
Statin use is widespread in middle - aged and older individuals, who also have an increased risk of AMD; however, previous studies have shown very little correlation
between regular
statin use and improvements i
statin use and improvements in AMD.
«Our finding that adherence is greater with generic
statins is consistent with other studies that have shown a direct relation
between higher copayments and lower adherence.»
On a wider scale, looking at the overall comparison
between the study's roughly 22,000 nonusers and 4,000 users, and statistically adjusting for certain factors, the researchers found a similar outcome: Users of
statins were more than twice as likely to develop diabetes.
These findings are generally consistent with those from recent systematic reviews, some of which also included trials of
statins for secondary prevention.47,51 - 53 Similar to other meta - analyses of primary and secondary prevention trials, 54,55 this review found no association
between use of
statins and increased risk of muscle - related harms, although some observational studies and randomized rechallenge trials found
statins associated with increased risk of myopathy or joint - related symptoms.56 - 58 The large HOPE - 3 trial found
statins associated with increased risk of cataract surgery, an unanticipated finding.14 No other trial of
statins for primary prevention evaluated risk of cataracts or cataract surgery.
2012: Physician - scientist Phuoc Tran, M.D., Ph.D., deciphered the relationship
between a cancer growth - promoting gene called c - myc and the ability of cholesterol - lowering drugs called
statins to decrease the risk of advanced prostate cancer.
Your doctor may start you on aspirin therapy — though its unclear why, aspirin seems to disrupt the link
between CRP levels and cardiac events — or, more likely, a
statin.
One study showed there was no significant difference
between the Portfolio diet and «
statin» therapy in lowering cholesterol and reducing C - reactive protein (CRP), a marker of inflammation.
«It is possible that older adults may not be able to distinguish
between muscle pain related to a
statin effect or an effect of aging and therefore adverse effects of
statins in older adults may be under - reported.»
All of the participants were
between the ages of 30 to 85, were part of a military health care system, and had been using
statins regularly for approximately two years.
«If we examine only direct costs, it looks like the cost of naturopathic care per unit reduction in the risk of cardiovascular disease is somewhere
between that of aspirin and that of
statin drugs.»
Of course, this association
between vitamin K2 and
statins is sadly ironic because
statins may actually be contributing to what they are suppose to treat: heart disease!
Furthermore, here's something MDs, who push
statin Rx's very readily don't tell patients / the public: a perfectly healthy, normal liver produces
between 2 thousand and 3 thousand mgs of cholesterol A DAY.
However, a small proportion of regular
statin users do experience significant side effects, with problems in the liver and kidneys reported in
between 1 - in - 1,000 and 1 - in - 10,000 people.
Case reports of mania induction with St John's wort have resulted in limited use of this herbal for the treatment of both major depressive disorder and bipolar disorder.45, 46 Interactions
between St John's wort and conventional drugs are mediated by the induction of cytochrome P - 450 3A4, which results in increased metabolism and decreased absorption of widely used drugs, including digoxin, anticoagulants, antiretrovirals, oral contraceptives,
statins, and cyclosporine.47
For example, even though the guidelines recommended that women
between the ages of 45 and 75 at increased risk of heart disease and with relatively high LDL levels take
statins, the fine print in the 284 - page document admitted, «Clinical trials of LDL lowering generally are lacking for this risk category.»