Sentences with phrase «between tumor cells»

Identifying and exploiting a novel mechanism that may disrupt this process by inhibiting the interactions between tumor cells and cells in the tumor environment will speed clinical investigations, and ultimately lead to improved outcomes for dogs with this devastating disease.

The ongoing work of the research teams seek to define the interactions between the tumor cells and their microenvironment that determine which lineage predominates, and that provide a safe niche for tumor growth and progression.

We report that ABL kinases promoted metastasis of breast cancer cells to bone by regulating the crosstalk between tumor cells and the bone microenvironment.

The crosstalk between tumor cells and the tumor microenvironment and how it orchestrates tumor progression and response to therapy

Bone metastasis requires reciprocal interactions between tumor cells, stromal cells, and bone cells (12, 26).

Given that endothelial cells play a central role in several rate - limiting steps of metastasis, the interactions that take place between tumor cells and endothelial cells have been the focus of much investigation.

The scientist explains that the nanoparticle works as a bridge of antitumor activation between tumor cells and T lymphocytes.

It's thought that the high pressure observed in tumors is a result of these abnormal blood vessels, which leak fluid and proteins into the area between tumor cells, known as the interstitial space.

New technologies are coming to the fore that allow interrogation of the types of cells interacting with tumors, in particular providing intelligence on the broad variety of complex associations between tumor cells and the immune system.

Not exact matches

«An index measures similarity between cancer cells and pluripotent stem cells: The new methodology measures tumor aggressiveness and the risk of relapse, helping doctors plan treatment.»

While many researchers are still developing affinity - based techniques for isolating circulating tumor cells, others are exploiting the physical differences between normal and tumor cells.

Scientists at the Rosalind Franklin University of Medicine and Science in Chicago found a «remarkable similarity» between the cells that support the growth and development in placentas and in tumors.

In effect, PD - 1 may actually help to preserve a «reserve force» of T cells that can fight on later in the long - term cellular war between the immune system and foreign invaders or tumors.

In the context of the collaboration between the Gates Center for Stem Cell Biology and the CU Cancer Center this was the second clinical trial we offered to our patients with the specific intent to eliminate the CSCs in their tumors.»

«For this purpose we have created molecules which act as an adapter between the virus and the tumor cell,» explains Markus Schmid, first author of the study.

The system, says Brahmer, provides a kind of «handshake» or connection between receptors on immune cells, called PD - 1, and their sister - proteins on tumor cells, called PD - L1.

A tissue slice, a tumor biopsy, or a sample of a bacterial culture yields a sequence representing the average of all of the cells within it, even though researchers know there can be tremendous variation between those cells.

They observed an intricate reciprocal regulation between Klotho, Wnt5A, melanoma cells, and the tumor microenvironment.

«An index measures similarity between cancer cells and pluripotent stem cells: The new methodology measures tumor aggressiveness and the risk of relapse, helping doctors plan treatment.»

«We started out by assuming a degree of similarity between some sub-populations of tumor cells and pluripotent stem cells,» Malta said.

But genetic similarities between metastasized and original tumors suggest that multiple cells move together to remote sites.

«In fact we found no link between cell phone usage and temporal lobe tumors, nor was there any association between handedness and tumor location.»

There is plenty of anecdotal evidence out there claiming a link between cell phone use and cancer: Keith Black, chairman of neurosurgery at Cedars - Sinai Medical Center in Los Angeles, says that the brain cancer (malignant glioma) that killed O. J. Simpson's attorney, Johnnie Cochran, was the result of frequent cell phone use, based on the fact that the tumor developed on the side of the head against which he held his phone.

«Indeed, when we studied the mice at the embryonic stage, we saw the cells between the muscle fibers expanded explosively and formed tumors early in development,» Hatley said.

«We conclude that KIF1B - β plays a key role in the decision between life and death for neural crest cells and tumors originating from the neural crest,» says Susanne Schlisio.

The border between tumor proliferating region and the necrotic region can be clearly visualized down to single cell with sharp contrast in glucose uptake activity.

Rather than target a tumor - suppressor gene directly, Ideker and team took the approach of identifying genetic interactions between a tumor suppressor gene and another gene, such that simultaneous disruption of both genes selectively kills cancer cells.

Using tumor biopsies from melanoma patients, the researchers could show that there is a positive correlation between the production of CCL5 and the infiltration of NK cells.

The size difference between tumor and healthy circulating DNA was initially discovered in animal tumor models created by inducing tumors with human cancer cells.

«High concordance between EGFR mutations from circulating - free tumor DNA and tumor tissue in non-small cell lung cancer.»

«These results provide an unprecedented window into the cellular dynamics of tumor evolution and suggest that interactions between subpopulations of tumor cell types contribute to metastatic progression from initial tumors,» Stanger said.

A surprising, paradoxical relationship between a tumor suppressor molecule and an oncogene may be the key to explaining and working around how breast cancer tumor cells become desensitized to a common cancer drug, found researchers at the Perelman School of Medicine at the University of Pennsylvania.

«We found a striking difference between the metabolic profiles of poorly aggressive and highly aggressive ovarian tumor cells, particularly with respect to their production and use of the amino acid glutamine,» said lead researcher Deepak Nagrath of Rice.

Cincinnati Cancer Center (CCC) and UC Cancer Institute researchers have found that a vaccine, targeting tumors that produce a certain protein and receptor responsible for communication between cells and the body's immune system, could initiate the immune response to fight cancer.

Human tumor tissue or cell lines can be coengrafted into these mouse models, providing a powerful tool for studying the interactions between human immune cells and human cancers.

In order to identify the cancer stem cells from other cells in the tumor, the research team studied epigenetic mechanisms that distinguish between the least - sorted cells, with endless division properties and a potential to create growth, and the more sorted cells which lack this ability.

UCLA scientists have unlocked an important mechanism that allows chemotherapy - carrying nanoparticles — extremely small objects between 1 and 100 nanometers (a billionth of a meter)-- to directly access pancreatic cancer tumors, thereby improving the ability to kill cancer cells and hence leading to more effective treatment outcome of the disease.

Surprisingly, they found that although the patterns of gene expression — as shown by the RNA sequencing — differed between the hepatocellular carcinomas and the liver cancers with biliary phenotype and depended on the histological type, the overall pattern of mutations in the cells was actually similar between the tumors — of either type — that had emerged in patients who had had infections with either hepatitis C or B, and were different in patients without such infections.

Genomic data from the HeLa cell line are also being released with the final version of the paper as a result of discussions between leaders of the National Institutes of Health (NIH) and relatives of Henrietta Lacks, from whose cervical tumor the original HeLa cell line was derived prior to her death in 1951.

Cancer researchers are just beginning to investigate the extent and significance of genetic differences among tumor cells — either cells within a discrete tumor or between a primary tumor and metastases in other parts of the body.

«Communication between lung tumors, bones contributes to tumor progression: Study identifying interaction among tumor cells, bone marrow and immune cells opens new avenue for immunotherapy.»

«Our findings indicate the existence of long - distance interactions between lung tumors and bones: lung tumors remotely activate osteoblasts, and those bone cells, in turn, shape immunity by supplying tumors with cancer - promoting neutrophils,» says Pittet, who is an associate professor of Radiology at Harvard Medical School.

As a result, the immune system, he says, «can identify antigenic differences between the foreign (tumor) and normal, and then go out and eliminate all cells displaying the foreign (tumor) antigens.»

In the Dec. 1 issue of Science, the team from the MGH Center for Systems Biology describes a «crosstalk» between lung tumors and bone marrow, which leads to the generation of a type of immune cell that travels to the tumor and promotes its progression.

The authors note that there are two different models of metastasis — one in which an advanced primary tumor disseminates metastatic cells late in its development, which would predict little genetic difference between primary and metastatic cells, and another in which metastasis occurs early in tumor development, which would predict significant genetic differences in metastatic cells that have evolved separately from those in the primary tumor.

We believe that each dog breed may correspond to one type of B - or T - cell lymphoma and so studies within and between breeds gives us a unique possibility to understand how the genetic background affects what type of tumor develops, and how its progression is regulated,» says Ingegerd Elvers.

«Study could explain link between high - cholesterol diet and colon cancer: Fats spur cells to divide faster, speeding tumor growth.»

Numerous studies have already shown that cancer spreads particularly aggressively if there is an unfavorable balance between suppressing and active immune cells in the tumor microenvironment.

Surgeons will monitor a traffic light - like video display as they cut, he explains, with red indicating tumor cells, green healthy tissue, and yellow something in between.

«When we compared the gene signature activity of glioblastoma cells from around 60 patients we found that a large number of patients could be divided into subgroups that showed a correlation between gene activity, tumor cell characteristics and cell of origin similar to the one we had seen in the mouse study.