Not exact matches
Roughly a year after Brazilian doctors and researchers first suspected a link
between a spate of alarming birth defects and the Zika
virus, a cadre of potential
vaccines are now headed for testing in humans.
«We could visualize this complex dance
between the
virus and the antibody and understand exactly how the
virus was teaching the antibody to be a broadly neutralizing antibody,» said Peter D. Kwong, Ph.D., chief of the Structural Biology Section at the NIAID
Vaccine Research Center.
In any given season, the effectiveness of the
vaccine depends on how good a match there is
between the
viruses used in the drug's production and the strains that are actually circulating that year.
«A successful
vaccine requires a fine balance
between efficacy and safety —
vaccines made from attenuated live
viruses generally offer fast and durable immunity, but sometimes with the trade - off of reduced safety, whereas inactivated and subunit
viruses often provide enhanced safety but may require several doses initially and periodic boosters.
This could be due to antigenic mismatch
between the circulating influenza
viruses and the
vaccine strains recommended by the WHO.
During the 2014 - 15 flu season, the poor match
between the
virus used to make the world's
vaccine stocks and the circulating seasonal
virus yielded a
vaccine that was less than 20 percent effective.
Their study found «a potential link
between the H1N1
virus used to make the
vaccine and narcolepsy.»
This result, effectively a method for blocking the spread of alphaviruses
between cells, is one that could eventually lead to a single
vaccine that protects against multiple
viruses.
Hybridising
between live
vaccine strains, or a live
vaccine and wild
viruses, is less predictable.
Two days after challenge with 106 TCID50 of SARS - CoV, titers in mice given PBS varied
between 107.0 and 108.0 TCID50 per g of tissue; one vaccinated animal in the group given the S protein
vaccine (SV) at the 3 µg and the 1 µg dosage without alum yielded
virus but all other animals in all other groups were culture negative for
virus (figure 3B).
All groups given the S protein
vaccine (SV) yielded
virus after challenge and the differences
between groups were significant (p = 0.002 for all groups, p = 0.023 for alum and p = 0.008 for no adjuvant, Kruskall - Wallis); also, geometric mean titers were higher for the groups given lower
vaccine dosages.
To differentiate
between vaccines, three
vaccine preparations were simultaneously evaluated, the double - inactivated (formalin and UV) whole
virus vaccine (DIV), the rDNA - expressed S protein
vaccine (SV), and the previously evaluated chimeric viral - like particle
vaccine (VLP) that had led to immunopathology with
virus challenge [16], [17], [20].
Those antibodies could be used to develop
vaccines to protect against Zika, as well as therapies to treat the
virus, according to the study, which was a collaboration
between researchers at UNC's Gillings School of Global Public Health and the UNC School of Medicine.
Used previously for dengue
virus studies, this cynomolgus macaque model will serve to better understand synergy
between these
viruses In an effort to help identify a
vaccine for the Zika -LSB-...]
Ever since Edward Jenner developed the first successful
vaccine against the dreaded smallpox
virus, researchers have been riveted by the interplay
between the body's defense mechanisms and pathogens staging an attack.
The nasal - spray version of the
vaccine, called the FluMist, (which is FDA - approved for kids and adults
between ages two and 49 who are healthy and not pregnant) does contain a crippled version of live flu
virus.
Superstar student Eric Chen noticed some similarities
between many the
viruses and invented a more effective flu
vaccine.
Rabies (1) is easily preventable, (2) the time
between exposure and onset of the disease allows time to stop the advancing
virus, and (3) the
vaccines used, when timely and correctly administered, are uniformly effective.
If you do not have an early shot record for your pet, bring in your puppy to receive a dose of canine parvovirus
vaccine between 14 and 16 weeks of age to develop adequate
virus protection.
Your puppy needs to be vaccinated with a series of
vaccines between the ages of 8 and about 20 weeks to protect him against the potentially deadly Parvo and Distemper
viruses.
Unfortunately, I don't believe that any of the available tests can distinguish
between the
virus and the
vaccine.
Canine Influenza Bivalent
Vaccine — These are highly contagious respiratory
viruses transmitted
between dogs.
Puppies are usually given killed rabies
vaccine, which uses a dead
virus, when they're
between 16 weeks and 4 months of age.
Likewise, while links
between external cancer - causing agents — such as environmental carcinogens, exposure to sunlight,
viruses, and
vaccine injections — have been established in relation to various other forms of feline cancer, these factors do not appear relevant to the onset of mammary cancer in cats.
Among other benefits, breastfeeding: stimulates the release of the hormone oxytocin in the mother's body promoting bonding
between mother and baby; satisfies baby's emotional needs; provides superior nutrition; helps prevent maternal breast cancer, endometrial cancer, ovarian cancer and osteoporosis; helps prevent future breast cancer in infant girls; promotes higher infant IQ; helps pass baby's meconium; provides immunization against disease; is more digestible than formula; aids in mother's post-partum physical recovery; helps protect the infant from Crohn's disease, juvenile diabetes, allergies, asthma, SIDS, hemophilus b.
virus, cardopulmonary distress, ulcerative colitis, necrotizing enterocolitis, and other medical problems; enhances
vaccine effectiveness, and is a natural contraceptive.