In addition, in collaboration with the Harvard Medical School bioinformatics team, he discovered (4) how global parameters of the transcriptome differ
between various cell types.
For that to happen, a complex, only partially understood interplay takes place
between various cell types in our skin.
A healthy optic nerve has axons transmitting information from the eye to the brain along the nerve after considerable information processing and synaptic transmission
between various cell types within the retina.
Not exact matches
Now, a collaboration
between the RIKEN Center for Integrative Medical Science (IMS) and other institutions in Japan and Europe have found that in immune
cells, simply blocking a transcription factor that leads to differentiation is sufficient to keep
cells in a multipotent stem
cell - like state where they can continue to proliferate and can later differentiate into
various cell types.
Cancer Institute research highlights include innovative studies to develop individualized approaches for treatment and prevention of lung cancer; collaboration
between medical and materials science researchers to develop treatments for
various types of leukemia using nanotechnology to target only cancer
cells; and development of novel therapeutics to treat metastatic melanoma using an approach that regulates the processes leading to tumor development.
RIG - G gene expression can be induced not only by ATRA along with the differentiation of NB4
cells but also by IFNα in a series of hematopoietic
cell lines as well as
various types of solid carcinoma
cells (1, 3), which pointed to a possible role of RIG - G in signal cross-talk
between ATRA and IFNα.
The reason for these differential effects of hypoxia may be due to the complex regulation of HIF - 1α activities by
various subunits, posttranslational modifications, and the presence and effects of coregulators, which are known to vary
between different
cell types (6).