I think that we need to be increasingly thinking
beyond gene finding and onwards to connecting the dots between genetic implication and functional understanding.
Not exact matches
«We wanted to
find out if obesity - related
genes and activity level have an interactive effect on obesity risk — if there is a «double whammy» effect of being both at genetic risk and physically inactive,
beyond the additive effect of these factors,» said Dr. Wood.
The researchers
found that,
beyond conferring resistance to proteasome inhibitors, the suppressed expression of proteasome subunits reflects a broad remodeling of the cell's
gene signature.
Finland's genetic uniformity, which facilitates
finding disease
genes, has served science far
beyond its borders.
Beyond offering further proof that single
genes can have dramatic influences on longevity, an idea that drew skepticism just a decade ago, the new
finding may help scientists explain how severely reducing calorie intake extends life span in a variety of animals (SN: 11/25/00, p. 341: Low - cal diet may reduce cancer in monkeys).
Other researchers have looked
beyond changes in behavior or physical features for «parallel evolution» in the
genes,
finding, for instance, that different insects alter the same DNA to help them feed on toxic plants.
When the researchers looked at the role of
genes that were methylated by
genes with code differences related to ASD, including additional
genes beyond those with direct code changes, they
found that the majority were involved in biological pathways that were important in immune function.
Like Page's group, the Swiss team also
found that Y chromosome
genes were expressed in a variety of tissues
beyond those involved in sexual development and are dosage - dependent.