Machete is pursued by an assassin called The Chameleon who keeps changing faces, and is played by Cuba Gooding Jr., Antonio Banderas and Lady Gaga, who make little impression
beyond small cameos.
There are a few interesting
cameos (
beyond Julie Andrews and John Cleese as the queen and king, respectively) like Jane Lynch and Jon Hamm, who get
small supporting roles, though you can barely tell it's them.