Sentences with phrase «bilayer membrane»

Synthetic transporters that can carry chloride through lipid - bilayer membranes have been developed that could potentially replace the function of faulty channels.

Such protein pores have desirable proportions, but the lipid bilayer membranes in which they are inserted are akin to a film of soap, which leaves much to be desired in terms of durability and robustness.

Not exact matches

These findings support a role of the bilayer - deforming properties of amphiphysin at T - tubules and, more generally, a physiological role of amphiphysin in membrane deformation.

Scramblases contain a membrane - exposed polar furrow, which allows for the diffusion of lipid headgroups across the lipid bilayer.

Changes to the properties of the lipid bilayer component of the cell membrane can alter the function of proteins embedded in the membrane — proteins that regulate critical functions such as transport of materials in and out of the cell and communication with other cells.

This is gramicidin, a membrane - spanning protein used to monitor lipid bilayer disruption in the Gramicidin - Based Fluorescence Assay.

«As we gathered data, we began to notice a trend: molecules that significantly affected lipid bilayer properties were often indiscriminate modifiers of membrane protein function and thus tended to have an array of off - target effects,» said researcher Lea Sanford.

That is, when compounds intended to influence a specific protein target also alter lipid bilayer properties, they may alter the function of numerous membrane proteins and thereby cause a cascade of usually unwanted off - target and side effects.

The MSRs were then coated with lipids that formed a thin supported lipid bilayer (SLB), which resembles the outer membrane of APCs and that the researchers then functionalized with a pair of T cell - stimulating antibodies that remain mobile in the lipid layer and can bind to receptor / co-receptor molecules on the surface of T cells.

In contrast, the cell membrane that the ion channel passes through is built from a bilayer of lipids, which are a form of fat that repels water - soluble substances.

In essence, however, the behavior of the channel proteins in the artificial membranes is comparable to that in their natural environment, the lipid bilayer, with the time scale of the movements being approximately ten times lower.

All three channel proteins were able to move freely within the membranes of various thicknesses — this took up to ten times longer than in the lipid bilayers of their natural environment.

A cell membrane, plasma membrane or plasmalemma is a selectively permeable lipid bilayer coated by proteins which comprises the outer layer of a cell.

These bilayers consisted of lipid domains — collections of lipids that in non-fusion circumstances are organized in more or less regularly occurring or mixed arrangements within the cell membrane.

The fundamental insights provided by this device could also prove useful for other materials in which dynamic changes occur between membranes, including surfactant monolayers and bilayers, biomolecules, colloidal particles, surfactant - coated nanoparticles and smart materials.

A fatty, two - dimensional bilayer pairs with a protein - rich cytoskeleton to form the membrane.

Improved method of preparation of supported planar lipid bilayers as artificial membranes for antigen presentation.

A cell's membrane is its natural barrier between the inside of a cell and the outside world — composed of a double layer (bilayer) of lipids (such as fats, waxes, sterols, or fat - soluble vitamins).

It is known that when one type of BAR - domain, called N - BAR, is recruited to the cell membrane, it penetrates the cell's lipid bilayer, inducing the formation of a small inward curvature.

I discovered that hopanoids interact with glycolipids in bacterial outer membranes to form a highly ordered bilayer in a manner analogous to the interaction of sterols with sphingolipids in eukaryotic plasma membranes (Saenz et al., 2015).

The membrane fusion activity of HR1 is associated with its capacity to insert into lipid bilayers, notably in regions presenting lipid packing defects.

«Lens membranes with a high content of saturated sphingolipids... are less susceptible to oxidation because there is relatively less oxygen in these ordered bilayers, as well as fewer double bonds to become oxidized... (W) hale lens lipid composition and structure support the finding that lens lipid hydrocarbon order is directly related to the sphingolipid content and indirectly related to the phosphatidylcholine content of the lenses of many animals.»

Solution - NMR characterization of outer - membrane protein A from E. coli in lipid bilayer nanodiscs and detergent micelles.

The starting point of my new interest were two fundamental questions: Why do eukaryotic organisms invest that much energy into synthetizing a dazzling array of lipids, when only one lipid is sufficient to form a functional membrane bilayer?

The dietary balance of omega - 6 to omega - 3 fatty acids, which compete for incorporation into the phospholipid bilayer of cellular membranes, is integral for restoration of immune health and for prevention of long - latency, chronic, and degenerative diseases.

From a physiological and biochemical perspective, the cell membrane consists of a «phospholipid bilayer» — two rows of molecules composed primarily of fats (lipids) and phosphorus (in a special form called «phosphate» that involves a combination of phosphorus with oxygen and hydrogen).