To achieve this, the scientists fused SiR molecules with compounds that
bind tubulin or actin.
One such compound was docetaxel, an anticancer drug that
binds tubulin, and the other jasplakinolide, which specifically binds the cytoskeletal form of actin.
Not exact matches
When a kinesin protein reaches the end, it detaches from the filament taking the
tubulin to which it is
bound with it.
They added a
tubulin -
binding protein known as Tau, that connects the HyPer protein to the microtubule structures.
The challenge was getting SiR to
bind specifically to the cytoskeleton's proteins, actin and
tubulin.
Tubulin - mediated
binding of human immunodeficiency virus - 1 Tat to the cytoskeleton causes proteasomal - dependent degradation of microtubule - associated protein 2 and neuronal damage.
Interference with a host of cellular functions tested and synergistic activities with a wide range of other drugs is best explained by direct interaction with various DNA sequences and general interference with replication and transcription, except for some effects exerted by
binding to
tubulin.
Specific interaction of benzimidazole anthelmintics with
tubulin: high - affinity
binding and benzimidazole resistance in Haemonchus contortus.
Importantly, the composite genomes of Asgard archaea encode homologs of actin genes, actin -
binding proteins, multiple ESCRT complex homologues, and
tubulin.