Sentences with phrase «binding cell surface»

Moreover, the intact mAb 5.91 was able to bind the free IgE to prevent it from binding cell surface receptors.

Not exact matches

It then travels down the respiratory tract and binds to epithelial cells lining the lung airways via specific molecules on the cell surface.

In my cell biology course, we investigate the biology and chemistry of a cell surface receptor that helps induce good feelings in us when it binds to a chemical compound found in incense; this may help explain why so many different cultures and religions have independently evolved the use of incense in their ceremonies and rituals.

In particular, the PTPRF gene, which is known to suppress intracellular signals that are usually triggered by insulin binding to its receptor on the cell surface, may serve as a biomarker linking insulin resistance with insufficient milk supply.

When similar analysis was performed on the db mice, it was found that the disrupted db gene was responsible for encoding a protein that functions as a leptin receptor: When it binds circulating leptin at the cell surface, it sets in motion a biochemical cascade inside the cell.

The antibody binds to a protein on the surface of T cells called the PD - 1 receptor.

The protein expressed by the gene is thought to bind to serotonin receptor molecules and ferry them to the cell surface, positioning them to receive serotonin's signals from neighboring cells.

The effort is complicated because there are some 16 types of key surface proteins (hemagglutinin) that help the virus bind to host cells, in addition to the several varieties of viral neuraminidase proteins.

This, Maguire said, may be the reason why the bubble - wrapped form of AAV, or exo - AAV, binds more easily to the surfaces of hair cells and penetrates them more efficiently.

Epitopes are displayed on the surface of circulating immune cells and are where T cells bind antigens to fuel the immune response.

In another study, Rezende helped functionally characterize the specific fragments of the cell surface protein, Als5p, that allows the pathogenic fungus, Candida albicans, to bind to its host.

This drug (vedolizumab) blocks a specific adhesion molecule on the surface of the T - cell and thereby inhibits immune cells from binding themselves to receptors present in the intestine, preventing the T - cells from penetrating the blood vessels in the intestinal tissue.

The fungal toxin binds to specific sugar structures which occur on the surface of intestinal cells of the nematode Caenorhabditis elegans.

But the London researchers have shown a few small changes in the shape of a surface protein were all it took to enable the bird version of Spanish flu to bind onto human cells.

The team found that after exposure to chemotherapy, the cells began developing physical markings usually seen in CSCs, including receptors on the cell surface to which specific proteins can bind.

The protruding orange structures are surface glycoprotein trimers, which allow HIV to bind and fuse with the host cell.

SapC - DOPS binds with exposed patches of the phospholipid phosphatidylserine (PtdSer) on the surface of tumor cells;

Using this strategy, researchers can engineer specific cells to produce a surface receptor that binds to a chemical compound known as CNO, a derivative of clozapine.

King hypothesizes that proteins that the single - celled ancestors of animals used to interact with the extracellular environment — to capture bacterial prey by binding to their cell surface and to detect chemical signals — were later repurposed to enable cells to stick to and talk to each other.

To address this challenge, Koide, Miller and their teams designed monobodies that bound to target locations on the fluoride ion channel - specifically, two small surfaces not embedded within the cell membrane.

The task of HLAs is to bind to fragments of proteins that are broken down in the cells, transport the fragments to the cell surface and present them to the T - lymphocytes.

The mushroom - shaped protein specializes in infecting cells, first by binding a trio of sites on its head to three separate sugar molecules on the surface of targeted cells.

Researchers studied the structure of proteins from one strain of the H7N9 virus that caused the outbreak and tested how strongly one of the proteins bound to molecules on the surfaces of bird and human cells.

«The antibody binds to a specific protein, called CD44s, which is expressed on the surface of pancreatic cancer stem cells.

The T cell's self - destruct program is turned on when a molecule on its surface, called Fas, binds to a protein called Fas ligand.

But when PD - 1 binds to proteins called PD - L1 and PD - L2 on the surface of certain cancer cells, the T cells essentially become paralyzed: the immune attack on cancer is called off.

Ulijn's gel is composed of two simple synthetic peptide derivatives: (1) a component that binds to copies of itself with high directional preference, resulting in the spontaneous formation of nanoscale fibers when the molecules are dissolved in water, and (2) a surfactant - like molecule that associates with the fiber surface and presents simple, cell - compatible chemical groups.

2) Protein binds to CD3 receptor on helper T cell, activating it so the helper T cell starts making HIV and displaying pieces of virus (red) on its surface.

The engineered protein has two ends: one activates T cells by binding to a surface molecule called the CD3 receptor, and the other — based on an antibody called VRC07 — powerfully binds to more than 90 percent of HIV strains.

In normal cell function messenger chemicals, such as various growth factors and insulin, bind to protein receptors on the cell's surface.

The toxins overcome the cell membrane by binding to a surface receptor, which conveys them into the cell's interior.

By binding to the surface receptor, the toxins are able to overcome the cell membrane.

When PDGF arrives at the cell surface, it binds to a protein called PDGF receptor tyrosine kinase (PDGF RTK).

In this situation, oxygen that enters the light organ is bound to the surface of the cell's energy - producing organelles, called the mitrochondria, and is thereby not available for transport further within the light organ.

It binds to heparan sulphate without degrading it, and also binds to proteins on the surfaces of T cells.

The rheumatoid arthritis drug, an anti-inflammatory, physically binds to cadherin - 11 (CDH - 11) on the surface of cells so that they can't bind together.

The MSRs were then coated with lipids that formed a thin supported lipid bilayer (SLB), which resembles the outer membrane of APCs and that the researchers then functionalized with a pair of T cell - stimulating antibodies that remain mobile in the lipid layer and can bind to receptor / co-receptor molecules on the surface of T cells.

«The NILR1 is the genetic code for a receptor protein that is localized to the surface of plant cells and is able to bind and recognize other molecules,» says Prof. Florian Grundler, chair at the Department of Molecular Phytomedicine at the University of Bonn.

MERS CoV (CoV stands for coronavirus) has on its surface an array of spike - shaped proteins that bind to host cells — specifically to receptor proteins called DPP4 on the surface of cells that line human airways.

A radio - labeled human antibody binds to the viral gp41 protein expressed on the surface of the HIV - infected human lymphocyte and the cell is killed by alpha radiation delivered by the antibody.

By March 2014 — about the time the epidemic was detected, but some 3 months after the first case actually occurred — the sequences had split into two distinct lineages, one of which was characterized by a single amino acid change in a region of the virus's surface protein and allows it to bind to cells.

Hemagglutinin binds to glycan receptors found on the surface of respiratory cells, and the strength of that binding determines how effectively the virus can infect those cells.

This in vivo reconstitution system provides a new approach for examining ligand binding and G protein coupling to cell surface receptors.

S. mansoni IPSE binds to Immunoglobulin E (IgE), an antibody produced by the immune system that is expressed on the surface of basophils, a type of immune cell; and mast cells, another immune cell that mediates inflammation; and sequesters chemokines, signaling proteins that alert white cells to infection sites.

PD - 1 (programmed cell death protein 1) is a receptor on the surface of T cells (the white blood cells that are part of the immune system), while PD - L1 (programmed death - ligand 1) is a molecule that binds to PD - 1 and is often over-expressed on the surface of cancer cells, enabling them to evade the immune system and allow cancer to grow and spread.

Now a team of researchers led by Philip Kim, a professor of computer science and molecular genetics in the University of Toronto's Donnelly Centre for Cellular and Biomolecular Research, has developed a new technology for making mirror - image peptides, which bind and activate receptors on the surface of cells.

Research groups in Munich, Essen, and Brussels have now detected a highly specific and exceptionally strong variant of this adhesion, in which the bacterial surface molecule HopQ binds itself to so - called «Carcinoembryonic Antigen - Related Cell Adhesion Molecules,» or CEACAMs for short, inside the stomach.

A protein on the cell surface of P. syringae binds water in a way that mimics the structure of an ice crystal, and this helps start the transformation of cold water into ice.

The impulses cause glutamate (one of the brain's main neurotransmitters) to pop out of one nerve cell and travel across the synapse to activate the next by binding to its receptors, chemically active signaling stations on the cell surface.

When attractant or repellant chemicals attach themselves to receptor sites on the surface membrane of a bacterium, it triggers a process within the cell that leads to the modification of the signal protein, CheY (pronounced «Key - Y»), enabling it to bind to the switch and change the bacteria's direction of movement.