Sentences with phrase «binding partners»

Moreover, the movements of the water molecules have proved to be specific for certain binding partners.

Please understand that each book is custom made by a team of expert book printing and binding partners when you place the order.

The study focused on a small subset of nuclear receptors, a large family of proteins that regulate gene expression in response to signals from various binding partners, including steroids and fats.

We discovered STK38 as a novel binding partner of Beclin1, a key regulator of autophagy.

Neurexins interact with binding partners called neuroligins to link neighboring nerve cells together so that signals can be sent and received correctly.

It was demonstrated that the movement of water molecules in the vicinity of the protein's active centre, the so - called binding pocket, is connected to potential binding partners in the water solvent.

Different protein binding partners bind to different PDZ domains within GRIP.

The lab is currently focusing on novel binding partners for 4 - 1BB, such as Galectin - 9, that control its functional activity, and how suppressive signals from 4 - 1BB or 4 - 1BBL downregulate T cell and APC activities.

We are currently investigating the details of the signaling cascades involved in these phenomena, as well as attempting to identify cytoplasmic binding partners for NG2 which may serve as effector molecules for activation of downstream signaling events.

«In contrast to previously known binding partners of the bacterium, this bond is independent of sugar structures.

These data suggest that IL - 15Rα alone should not be considered merely a subunit of the trimeric IL - 15 receptor, but is likely an integral binding partner that can alter IL - 15 biological activity.

Each of the twenty - one amino acids used by the human body has a tRNA binding partner that carries it to the ribosome where it can be incorporated at the appropriate point into a growing protein.

Thus, many researchers, who have identified PTMs that are often unique signatures of a certain cancer, send us their modified proteins in the hopes that we can identify relevant binding partners.

Similarly, CDK4, which encodes cyclin - dependent kinase 4, a targetable binding partner of cyclin D1, is more commonly amplified in mucosal than in cutaneous melanomas.

Computer programs simulate these interactions to predict the optimal spatial relationship between binding partners.

He still remembers getting the result on a Saturday morning; the abilities of the two proteins to each bind to their CDK binding partners were the same, as were their inabilities to bind to either p21 or p27.

They also have alliance bound partners such as Jal, Qantas, KLM, and British Airways.

Finger swiping is quieter, sparing your sleep bound partner the roaring swish of pages turning; but glass tops just don't feel... right and can't be held by the corner in anticipation, or reluctance, as you prepare to move ahead.

For example, our past work showed that two conserved tyrosine phosphorylation sites in the juxtamembrane segment of the Eph receptors not only mediate association with binding partners but also regulate receptor kinase activity.

But researchers haven't been able to identify the sperm's binding partner in the layer, although their suspicions have fallen on two of the glycoproteins, ZP2 and ZP3.

The study, whose co-first authors were Micah Niphakis, who at the time was a postdoctoral fellow in the Cravatt laboratory, and graduate student Kenneth M. Lum, emerged from an effort to discover protein - binding partners of arachidonoyl lipids, which are involved in many physiological responses such as pain, inflammation, mood and appetite.

«The knowledge of the structure of the protein, along with its molecular binding partners, will enable us to greatly advance the understanding of how a-Klotho works and also how to best design therapeutic strategies and novel agents that can either activate or block FGF23 - a-Klotho interaction and signaling as needed.»

Niphakis began by making probe molecules that mimic the structure of arachidonoyl lipids and capture protein - binding partners when exposed to ultraviolet light.

These findings suggest that the therapeutic protein was able to interact normally with its binding partners among the USH1 molecular complex (the proteins cadherin 23, protocadherin 15, myosin VIIA and harmonin), as required for the mechanoelectrical transduction apparatus of the hair bundle to function correctly.

Interaction between the PD - 1 protein found on killer T cells and its binding partner PD - 1L is one hallmark of immune exhaustion, and interfering with this interaction a potential strategy to overcome it.

And even if they are able to flop around a bit in their natural states within the cell, surely they snap into structured positions when they encounter their binding partners, just as Kriwacki's p21 did.

«Our data clearly showed that one of the protein receptors on white blood cells called CXCR3 brings white blood cells to the optic nerve in response to production of its binding partner CXCL10 by damaged nerve tissue,» said Zhang.

To conclude, such correlated water movements could support the interaction of biomolecules like enzymes and proteins with their binding partners and play a significant role in their mutual recognition, allowing the biomolecule to select or reject certain binding partners.

Schematic diagram of the hydration funnel in an enzyme - substrate complex (the protein is depicted in grey, its binding partner in green, and the funnel in yellow).

When Notch is switched on, it binds to DNA only after binding to a DNA - binding partner.

A cell signal pathway with constitutive activity requires no binding partner (ligand) to activate; instead, the signaling circuit continually activates itself.

We identified c - Jun amino - terminal kinase 3 (JNK3) as a binding partner of β - arrestin 2 using a yeast two - hybrid screen and by coimmunoprecipitation from mouse brain extracts or cotransfected COS - 7 cells.

In the course of the reaction, an atom or a group of atoms bound to a molecule is exchanged by another binding partner.

Furthermore, this new phenomenon has been shown to depend on the binding partner, being the optimized molecular architecture of a binding partner critical for water - mediated effective binding.

Martemyanov explains that GPR158 is a so - called «orphan receptor» (which gets its name because its binding partner / partners are unknown) with a poorly understood biology and mechanism of action.

As Niphakis and his colleagues worked with the probes, they found they could quickly generate extensive maps of a given lipid's protein - binding partners and, in many cases, even map the region of the protein that the lipid probes bound — information that could be put to multiple uses.

Eph receptors and their binding partners, the ephrins, are found on the surface of almost all cell types.

The authors point out that their software can help to explore the interactions between molecules in living organisms: For example, it could help determine whether molecules are slowed down by interacting with (maybe so far undiscovered) binding partners.

Once receptors sense the presence of these binding partners, they send out new signals that initiate other cellular processes.

Importantly, reducing p62 levels markedly increases SMN and its binding partner gemin2, promotes MN survival and extends lifespan in fly and mouse SMA models revealing p62 as a new potential therapeutic target to treat SMA.

When the antibody — in this case anti-MtrC or anti-OmcA — comes in contact with its binding partner, a measurable force is required to separate the two.

In collaboration with Richard Kriwacki, Ph.D. at St. Jude Children's Research Hospital, Marassi's proteins were used to show that Bcl - xL's IDR controls the core's ability to interact with its binding partners.

In the case of switchSENSE, this is the additional information on size and conformational changes of the binding partners.

However, the MIT team have developed a way to precisely block HDAC2's interaction with a binding partner, Sp3.

Antibodies generated against PD - 1 (anti-PD-1) or its binding partner (anti-PD-L1) block the pathway's activation, in effect releasing the brakes on the immune response.