Sentences with phrase «binding proteins»

As RNA - binding proteins are still systematically understudied, we will provide important insights of the roles of a key player in post-transcriptional regulation of gene expression.

DNA / RNA - binding proteins, a fancy type of protein that «guards» the genetic instructions running brain cells, are known to be important in diseases like Alzheimer's and motor neuron disease.

For nearly a decade, Sattler made contributions to RNA research, working to tease out how RNA binding proteins uniquely bind to specific RNA and regulate gene expression.

Proteins found in stress granules include RNA - binding proteins like TDP - 43, FUS, hnRNPA1 and hnRNPA2B1 that regulate gene activity.

These questions led Darnell's lab to discover and explore the function of neuron - specific RNA - binding proteins in the mammalian brain.

The Cheng lab develops technologies based on artificial DNA and RNA binding proteins and applies them to sense or induce sequence or epigenetic changes at target genomic loci or target transcripts.

Robert Darnell's work identifying the target proteins for a group of rare brain disorders has led to an emerging understanding of the roles of RNA regulation, including the discovery that neurons make a unique set of RNA - binding proteins.

We identified members of most classes of recognition proteins found in other insects (Table S1), including 3 β - glucan binding proteins, 12 PGRPs, 3 TEPs, and 9 proteins with NIM repeats.

«I started to realize there are all these interesting RNA binding proteins that are not well understood,» says Sattler, who also expanded his solution - based methods to include small angle x-ray scattering and small angle neutron scattering while at EMBL.

Pulling FP - binding proteins out of the entire proteome of test cells and identifying them using mass spectrometry techniques, the team matched nearly all to known hydrolases.

The second is that one of the options available in the programme was a project on RNA - binding proteins as markers of cancer progression.

Importantly, the composite genomes of Asgard archaea encode homologs of actin genes, actin - binding proteins, multiple ESCRT complex homologues, and tubulin.

To synthesize the enzymes necessary to make cholesterol, SREBPs, short for sterol regulatory element binding proteins, have special functions.

Prior to Cas9 activators, similar tools were made using other DNA binding proteins such as zinc fingers (ZF) and TAL effectors (TALE).

Periplasmic binding proteins (PBPs), normally involved in bacterial chemotaxis, have been computationally re-designed to produce highly specific and sensitive bio-sensing capacities for substances such as explosives, a chemical agent surrogate, and a metal [2], [3], [4], [5].

The alpha actinin (ACTN) family proteins are actin - binding proteins that regulate cytokinesis, cell adhesion, spreading, migration and signaling to control cell function.

In a new study published in the journal Science, a team of researchers has described how DNA - binding proteins (called transcription factors) react to and interpret these «epigenetic» changes.

«switchSENSE ® allows us to measure affinity and kinetics of DNA - binding proteins which we are unable to analyze with any other method.

Intracellular localization and interaction of mRNA binding proteins as detected by FRET.

Blasco PM, María A. Telomeric and extra-telomeric roles for telomerase and the telomere - binding proteins.

The SMC5 / 6 complex maintains telomere length in ALT cancer cells through SUMOylation of telomere - binding proteins.

Other genes relevant for regulating blood cholesterol levels are well - expressed in enhanced hiPS - HEP cells, e.g., apolipoprotein B (a VLDL), apolipoprotein A1 (an HDL), PCSK9, sterol regulatory element - binding proteins 1 and 2 (SREBP - 1 and -2), and lipoprotein lipase (LPL), which hydrolyzes triglycerides in lipoproteins into free fatty acids and glycerol.

Proteomic identification of phosphatidylinositol (3, 4, 5) triphosphate - binding proteins in Dictyostelium discoideum.

Using mouse skeletal muscle stem cells as a model, we show that accumulating transcripts specifying the myogenic program are not translated in quiescent satellite cells, but are repressed by the action of microRNAs and RNA binding proteins.

Using recombinant protein expression we can produce milligram quantities of recombinant convertases, as well as of their two endogenous binding proteins.

A successful candidate should have the following qualifications: a Ph.D. in the field of Molecular Biology, Cell Biology, Biochemistry or related field; an established track - record of publications in peer - reviewed journals; solid experience in the biochemistry of complex DNA - binding proteins (such as chromatin remodeling factors or DNA repair proteins), their purification from heterologous expression systems as well as their characterization using functional studies such as by isothermal titration calorimetry fluorescence, transcription assays.

Christin Suess (Solimena, TUD)-- «mRNA binding proteins as early response factors of stimulated insulinoma INS - 1 cells» (2008)

The Rep protein of adeno - associated virus type 2 interacts with single - stranded DNA - binding proteins that enhance viral replication.

FRET - detectable interactions between the ARE binding proteins, HuR and p37AUF1.

We study the cell biology, binding proteins, structure and regulation of these important enzymes, using neuroendocrine cell lines as model systems.

We analyzed the role of DNM2 and several actin binding proteins on clathrin plaque function at costameres in vitro by using either siRNA depletion combined to high resolution electron microscopy or in vivo by intravital microscopy.

GAS2 - like proteins mediate communication between microtubules and actin through interactions with end - binding proteins.

Side - binding proteins modulate actin filament dynamics.

Leukocyte protease binding to nucleic acids promotes nuclear localization and cleavage of nucleic acid binding proteins.

A possible secondary project will address the role of convertase binding proteins that play a role as endogenous secretory chaperones in Alzheimer's and Parkinson's diseases.

The dynamic interaction of the three RNA - binding proteins in RNA granules will be analyzed in detail.

In this project, we will analyze the dynamics of FNR association with different complexes, and investigate the structural mechanism that regulates FNR recruit - ment and release from FNR binding proteins.

RNA granules can be considered as dynamic cellular microcompartments that contain a subset of different mRNA species and various mRNA - binding proteins.

A protein domain that is found in many RNA - binding proteins that are required for mRNA synthesis, pre-mRNA splicing, ribosome biogenesis and RNA decay.

Along this line, our primary research goals are directed towards understanding how noncoding RNAs and their RNA - binding proteins are integrated in to the regulation of gene expression and modulation of the host immune response during gammaherpesvirus infection.

The project will focus on the mechanisms by which the three tau - mRNA binding proteins HuD, IMP - 1 and G3BP - 1 affect tau localization and expression in neurons.

A common characteristic of ALS and frontotemporal dementia is the build - up of clumps of misfolded RNA - binding proteins, including a protein called FUS, in the brain and spinal cord.

A family of cis — trans peptidylprolyl isomerases that includes cyclophilins and FK506 - binding proteins (FKBPs).

FNR that is soluble, associated with PSI, or tethered by the FNR binding proteins Tic62 and TROL could mediate this.

Along this line, our primary research goals are directed towards understanding how noncoding RNAs and their RNA - binding proteins are integrated in to the regulation of gene expression and modulation of the host immune response during ¿ - herpesviral infection.

Moreover, the repeat - containing RNA could be toxic, eventually by sequestering RNA - binding proteins in the nucleus.

RNA biology, genomics, RNA binding proteins, miRNAs, alternative splicing, translation, brain tumors

The researchers focused on glutamate - receptor and ligand - binding proteins that go through large conformational changes, like opening and closing, upon binding.

In addition to the propeptide, other binding proteins are capable of regulating myostatin activity in vitro, including follistatin [19], [21], FLRG [22], and Gasp - 1 [23].

Enhancers are recognized by DNA - binding proteins to augment or diminish transcription rates, but the exact mechanisms are poorly understood.