Sentences with phrase «binding sites»

However, the spikes present new binding sites for the human immune response to infection and as such, may present promising new targets for the development of different types of drugs.

In fact, researchers have detected over 3,000 different magnesium binding sites on human proteins, which means that magnesium's role in human health and disease processes may have been vastly underestimated.

The next generation of transcription factor binding site prediction.

And it was very interesting that it actually revealed new binding sites that had not been previously characterized.

Gradually eliminating low - affinity binding sites identified by the new algorithm results in a gradual reduction (from left to right) of gene expression (white) in fruit fly larvae.

Good nutrition is key because a deficiency of vital metals will lead to their replacement by toxic metals in enzyme binding sites.

In all cases a single binding site model was employed.

A joint industry / academia study of a cancer target protein reveals unusual relation between binding site flexibility and drug - target lifetime.

The more binding sites that are open, the lower the uptake result will be.

In this case, the quantum mapping resulted in the correct binding site for selected proteins.

To compensate for a catalyst with fewer binding sites, the current method of reduction creates high - pressure conditions to facilitate stronger bonds with carbon dioxide molecules.

Such simple binding sites can arise frequently in proteins.

At both arms of the «Y», a light chain is paired up with a heavy chain to form the unique binding site for each specific target.

High testosterone can cause high T3 uptake because it lowers binding sites.

Meanwhile, estrogen dominance increases binding sites leading to higher T4 and lower T3 uptake.

When the researchers wanted to examine in detail how the substances affect the ion channel, they discovered the new binding site.

The ChIP - Seq methodology is today one of the most widely used next generation sequencing applications, enabling researchers to reliably and simultaneously identify binding sites of a broad range of targets across the entire genome, with high resolution and without constraints.

Interestingly, not only the DNA that codes for these transcription factor genes is shared among the deuterostomes, but also some of the DNA pieces that are used as binding sites for the transcription factors are conserved among these animals.

This enabled them to build an atlas of specific binding sites within the context of whole cells.

An additional key insight gleaned from the structure, described in this week's Science, explains how the CCR5 receptor binding site on gp120 can have both the specificity required for tight binding and still be variable enough to allow the virus to switch to a different receptor in later stages of infection.

Mercury attaches and competes for cellular binding sites with other major trace minerals.

Elizabeth D. Prescott and David Julius of the University of California, San Francisco, investigated a specific binding site within TRPV1.

a) To measure the overlap coefficient of different antibody binding sites, the signals were separated from background using a brightness criterion and made binary.

Intensive efforts have been underway worldwide to develop improved rifampin derivatives that are unaffected by alterations of the rifampin binding site on Mtb RNAP and that thus can kill rifampin - resistant TB bacteria.

A second DNA binding site in human BRCA2 promotes homologous recombination Catharina von Nicolai, Åsa Ehlén, Charlotte Martin, Xiaodong Zhang & Aura Carreira Nature Communications 7, Article number: 12813 (2016), doi: 10.1038 / ncomms12813

The new method offers dramatic improvement for transcripts with highly conserved 3 ′ UTRs, which often have many «predicted» miRNA binding sites because so many computational methods rely on conservation.

The compounds were then docked into the same RIPK2 binding site in which ponatinib is located.

(A) Schematic representation of the potential β - catenin / TCF binding site within the flanking genomic sequence of the miR - 150 precursor.

They carry several neurotransmitter binding sites which govern the opening of a transmembrane ion channel.

At the molecular level, individual dynein molecules whose shapes are stabilized by prestress were found to have areas of increased rigidity around their ATP binding sites, which resist deformation by incoming energy from ATP and instead translate that force into the dynein molecule's characteristic movement.

Tyrosine phosphorylation sites (yellow circles) promote Eph kinase activity and also provide binding sites for signaling proteins containing SH2 domains.

Despite the thousands of predicted binding sites, each miRNA bound an average of 655 targets.

The transport protein contains an ion binding site located at the center of the membrane that is composed of conserved amino acids.

It was known that there are three possible binding sites on GW182 for Argonaute.

One approach is based on the combination of ATP - binding site inhibitors with so - called allosteric inhibitors, which bind to a different location.

Want to see how a protein unfolds or how a drug docks into a target protein binding site?

Evidence in this study suggests the high - risk variant we identified may be part of a larger network of CTCF binding sites involved in regulation in other genes with anti-viral activity.»

Lead author Neha Rani, a postdoctoral scholar in the Kosik Lab, identified several binding sites on lncND for another type of RNA called a microRNA.

However, work by Jiang's team, submitted for publication, finds that the MERS binding site also induces strong antibodies which should not elicit the unwanted effect.