Sentences with phrase «binding zinc finger proteins»
(A) A CXCR4 - specific ZFN pair was generated, comprised of two DNA - binding zinc finger proteins (ZFPs) each fused with a FokI endonuclease monomer.
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The fusion protein bound optimally to a sequence containing adjacent homeodomain (TAATTA) and zinc finger (NGGGNG) subsites.
For DNA cleavage to occur, two zinc finger proteins must bind, each to specific, adjoining sequences in the CCR5 gene, leading to FokI dimerization and subsequent DNA cleavage resulting in a double strand break [24]--[26].
A conserved role for the zinc finger polyadenosine RNA binding protein, ZC3H14, in control of poly (A) tail length.
Poly (ADP - ribose)- binding zinc finger motifs in DNA repair / checkpoint proteins.
Prior to Cas9 activators, similar tools were made using other DNA binding proteins such as zinc fingers (ZF) and TAL effectors (TALE).
Global analysis of Drosophila Cys2 - His2 zinc finger proteins reveals a multitude of novel recognition motifs and binding determinants.
Swapping the DNA binding domain of another telomeric protein, TRF2, with the zinc finger domains of TZAP showed that the TZAP zinc finger domains were sufficient to localize TRF2 to telomeres.