Not exact matches
That reaction results when a localized accumulation of
immune complexes — antibodies
bound to their antigens — is deposited in tissue and sets off an inflammatory response involving the infiltration and activation of
immune cells, initially the neutrophil.
After looking at lung samples from 75 young and middle - aged adult victims of the 2009 pandemic, they found an uncanny amount of a protein called C4d, a molecule that normally
binds to antibodies to form virus - fighting
immune complexes.
These results suggest that
immune complex - triggered inflammation is initiated by cell
bound Fc receptors and is then amplified by cellular mediators and activated complement.
Through this approach, she showed in mice that vaccine - induced
immune responses — which correlated with predicted MHC
binding affinity and the measured peptide - MHC
complex stability — were associated with positive outcomes.
These include: 1) live viral vaccine neutralization by maternal Abs, 2) Ab feedback mechanisms, 3) elimination of vaccine - antigen / maternal Ab
immune complexes by phagocytosis, 4) inhibition of B cell responses through epitope masking, and 5) inhibition of B cell responses by
binding of IgG to the FcγRIIB (134, 135).
They are
complex molecules which can only be produced by the
immune system of a living animal, and which recognise and
bind to very specific protein sequences.
When an antibody
binds with an antigen, an
immune complex occurs.