Sentences with phrase «bio-specific cell behavior»

Joe W. Ramos, PhD, deputy director of the UH Cancer Center and collaborators focused on investigating how these oncogenes and related signals lead to dysregulation of normal processes within the cell and activate highly mobile and invasive cancer cell behavior.

Other researchers have tried changing cell behavior by creating protein switches from scratch, but Lim's approach — mixing and matching naturally existing proteins — may be more versatile and practical: «It can be useful as a biotechnology device or for repairing cells in humans.

Also look at the institution's broader scientific environment, because «you can benefit from help even from people that are not with the label «biomaterials,»» says Dupont - Gillain, who, as a bioengineer and physical chemist, collaborates with colleagues in surface science and cell biologists to develop biomimetic surfaces that can trigger desired cell behaviors.

Tissue engineering provides a more practical means for researchers to study cell behavior, such as cancer cell resistance to therapy, and test new drugs or combinations of drugs to treat many diseases.

Similar to the naturally occurring effects of TET2 mutations in mice or humans, using molecular biology techniques to turn off TET2 in mice caused abnormal stem cell behavior.

The «domestication syndrome» in mammals: A unified explanation based on neural crest cell behavior and genetics.

The biomedical engineers also showed that the exosomes contain miRNAs — tiny pieces of RNA that regulate cell behavior and are known to play a role in neuronal differentiation.

For the subset of more recent patients, the researchers assessed tumor cell behavior — in particular, cancer cells» ability to cross the endothelium (inner layer) of blood vessels.

In the adult central nervous system, the vasculature of the neurogenic niche regulates neural stem cell behavior by providing circulating and secreted factors.

At the core of this cell behavior is how the loss of that single gene changes activation levels of dozens of other genes, suppressing genes associated with metastatic disease and increasing activity of genes linked to normal tissue.

«This is the first study to show the actual cell behaviors caused by mutations in genes causally linked to polycystic kidney disease, an important new step in the path towards treatment,» said Dr. Robert L. Bacallao, associate professor of medicine at the IU School of Medicine in Indianapolis.

The research suggests that reducing production of the protein, called myoferlin, affects cancer cells in two primary ways: by changing the activation of many genes involved in metastasis in favor of normal cell behavior, and by altering mechanical properties of cancer cells — including their shape and ability to invade — so they are more likely to remain nested together rather than breaking away to travel to other tissues.

The researchers also discovered an essential role for the mechanical properties, i.e. the physical stiffness, of the gel in regulating intestinal stem cell behavior, shedding light on how cells are able to sense, process and respond to physical stimuli.

His research group focuses on big data network biology, exploring biological systems by developing and deploying algorithms aimed to predict cell behavior, in particular looking at cellular signal processing and decision making.

Scientists think that these niches control stem cell behavior, that is «telling» the stem cell when to produce more stem cells or when to produce daughter cells that will be the workhorses for that tissue or organ.

For another, although the unusual T cell behavior was entirely absent in kids who didn't get autoantibodies later on, it was recorded in only about half who did.

A strategic focus is to continue to develop computational tools (such as KinomeXplorer, NetworKIN, and NetPhorest) and to deploy these on genome - scale quantitative data obtained by, for example, mass spectrometry, genomic, and phenotypic screens to understand the principles of how spatio and temporal assembly of mammalian signaling networks transmit and process information at a systems level in order to alter cell behavior.

«We came up with a way to derive a model of cell behavior, but the approach is complicated and slow, and it is limited in the number of variables that it can track — it can't be scaled to more complicated systems,» Wikswo says.

«We're seeing that some of these factors have a major impact on cell behavior that is not possible to observe in conventional 2D cell cultures.»

Marcus stresses that SaGA can be applied to additional cell types or environments, or other types of cancer cell behavior such as drug resistance.

The study recently published in «Cell Stem Cell» also shows that signals secreted by the choroid plexus dynamically change during aging which affects aged stem cell behavior.

The research team led by Prof. Fiona Doetsch at the Biozentrum of the University of Basel has now shown that the choroid plexus is a key component of the stem cell niche, whose properties change throughout life and affect stem cell behavior.

«These origami can be customized for use in everything from studying cell behavior to creating templates for the nanofabrication of electronic components,» says Dr. Thom LaBean, an associate professor of materials science and engineering at NC State and senior author of a paper describing the work.

Those data were then combined with information about functional changes in cell behavior to develop a nanomechanical profile, or phenotype, for specific cellular states.

The immediate application of the research, Sinha explains, is in helping scientists pinpoint important changes in cell behavior.

The research team tested the hypothesis by transplanting cells onto the surface of mouse bone grafts and studying the cell behavior both in vivo — inside the animal — and in vitro — outside the body.

On the material side, it's creating the right materials that are highly biocompatible and that stimulate the right growth and cell behavior.

Normally, MIR506 plays an important role in regulating cell behavior; adequate levels help the cells function normally, while decreased levels trigger cell growth and expansion occurring in tumors.

This insight into cell behavior could help researchers better understand cell jamming and unjamming, which could lead to potential treatments for conditions such as developmental abnormalities, asthma, and cancer.

The center will develop new single - cell approaches that overcome limitations inherent in traditional techniques — which analyze bulk populations of cells, thereby obscuring individual cell behavior.

The center also develops new approaches that overcome inherent limitations in traditional techniques, which analyze bulk populations of cells, thereby obscuring individual cell behavior.

The program also allowed the researchers to address aspects of cell behavior that emerge from vast numbers of interacting factors.

Without these tools, scientists are less able to link specific genes to cell behavior or determine how microbes interact within their environment and with one another — critical information for understanding how ocean ecosystems function.

Supported by National Institutes of Health grants, researchers at Oak Ridge National Laboratory (ORNL), the University of Tennessee (UT), and the UT — ORNL Joint Institute for Computational Sciences (JICS) discovered a molecular «switch» in a receptor that controls cell behavior using detailed molecular dynamics simulations on a computer called Anton built by D. E. Shaw Research in New York City.

Biological Function of Ribosomal Protein L10 on Cell Behavior in Human Epithelial Ovarian Cancer Jimin Shi, Lingyun Zhang, Daibing Zhou, Jinguo Zhang, Qunbo Lin, Wencai Guan, Jihong Zhang, Weimin Ren, Guoxiong Xu J. Cancer 2018; 9 (4): 745 - 756.

It is an enormously complicated and interdependent set of controls, still poorly understood to be sure, but the ability to change protein levels is in principle the ability to change cell behavior.

Macromolecular crowding directs extracellular matrix organization and mesenchymal stem cell behavior.

As new examples of beneficial noise come to light, scientists are working to better understand the implications for cell behavior, evolution and human health.

High - throughput data acquisition streamlines complex experiments, while simple protocols for multiplexed analysis provide deeper insight into cell behavior.

Our studies help in the design of biomaterials to promote bio-specific cell behavior (funded by the German Research Council SFB - TRR 67).

The glands lining the inner wall of the colon are the sites for most abnormal cell behavior such as uncontrolled cell growth, which results in polyps (non-cancerous growths) and later on in adenocarcinomas or tumors.

Manning believes that cell jamming likely provides an overarching mechanical explanation for many of the cell behaviors involved in cancer, including extrusion.

In the past few years, physicists studying metastasis have generated surprisingly precise predictions of cell behavior.

«Martin's vision for genetic analysis of pluripotency, afforded by our extensive mouse resources, could lead to major advances in our understanding and manipulation of stem cell behavior in health and disease.»

Martin's vision for genetic analysis of pluripotency... could lead to major advances in our understanding and manipulation of stem cell behavior in health and disease.

Rooney and his associate scientist Dr. George Hodnett will look at the cytogenetics — how chromosomes relate to cell behavior — of outcrossing between these two species and how they are influenced by sorghum genotype.

Since it is still beyond the reach of even the most sophisticated in vitro methodology to simulate the complex interplay of physical, cellular, biochemical, and other factors that influence cell behavior in microvessels and interstitial tissues, we make use of intravital microscopy.

Both mouse and human iPSCs are similar to embryonic stem cells (ESCs) with respect to their morphology, cell behavior, gene expression, epigenetic status and differentiation potential both in culture and in vivo.

We have a particular focus on glycosaminoglycans and have studied the role of heparan sulphate in embryonic stem cell behavior.

Conventional time - lapse recordings have provided new data of living cell behavior and growth.