The Laboratory of Protein Structure (LPS) started its activities in 2008 and focuses on structural and
biochemical studies of proteins (e.g.: nucleic acid enzymes) using protein crystallography as the primary method.
Unfortunately the Australian work did not use standard ancient DNA authentication tests, such as independent replication by other laboratories,
biochemical studies of bone preservation, and cloning of DNA sequences (to reveal amplification artefacts).
His thesis was entitled «Structural and
biochemical studies of Argonaute reveal the slicing mechanism of RISC - RNAi effector complex.»
Research in this area spans several disciplines, from
the biochemical study of basic mechanisms of alcohol metabolism, to the neuroscience of dependency, to demographic and clinical studies on at - risk populations.
At Berkeley, Emily completed her graduate studies with Prof. Michael A. Marletta where she focused on
the biochemical study of an enzyme relevant to human health.
Not exact matches
The Chinese government financed nationwide
studies into cockroaches» medical value that, after more than two decades
of laboratory investigation and clinical trials, had discovered or confirmed dozens
of disease - fighting proteins and
biochemical compounds with huge potential value in medicine.
In contrast, positive expectations
of treatment doubled the natural physiological or
biochemical effect
of the opioid drug among the healthy volunteers in the
study.
biochemical evidence such as Cytochrome - cyto - C is just one
of the thousands
of sequences and is not proof
of common ancestry, as there are more variations than similarities in the genetic code, on the other hand a
study of the amino acid make - up reveals that man is closer to lamprey than are fish.
In a related
study, rats were fed large amounts
of Tabasco ® Sauce and suffered «no gross or microscopic pathological changes or any significan
biochemical changes in the animals.»
Then, with an emphasis on Western society, they cover topics like marriage, fertility, paternity, cross-cultural
studies of father involvement, stepfathering, sexuality, health, and the
biochemical changes that babies make to a father's brain.
Studies show that early nurturing from parents or caregivers helps combat the
biochemical effects
of stress.
Now we need to
study how, in the real world, and in the long - term, the processes
of biochemical efficiency and lifespan will change.
In a new
study, published today in the journal Advanced Functional Materials, researchers used a combination
of 3D imaging and 3D printing techniques to create a custom silicone guide implanted with
biochemical cues to help nerve regeneration.
Investigators
studied liver tissue from patients with steatohepatitis, who were heavy alcohol drinkers, and from ethanol - fed mice to identify
biochemical markers
of cellular senescence.
The long - term objective
of Stahelin's research is to apply principles learned from
biochemical and biophysical
studies to generate novel therapeutics to combat Ebola.
To link, at a molecular level, a gene variant with
biochemical changes and clinical symptoms related to a heritable psychiatric disorder, as in this present
study, is therefore something
of a breakthrough.
I
studied the biological and
biochemical journals to keep up to date with the recent developments within my area
of research.
In a report on the
study, published Feb. 5 in Nature Neuroscience, researchers say the
biochemical receptor, known as a G protein - coupled receptor, was present on nerve cells in the lower respiratory tracts
of lab mice.
Chuyang Cheng, a fourth - year graduate student in Stoddart's laboratory and first author
of the paper, has spent his Ph.D.
studies researching molecules that mimic nature's
biochemical machinery.
And we have done many validation
studies where we compared our diet assessments to
biochemical measures, say
of, tansfat in the fat tissue
of a person or the level
of beta - carotene in the blood, and we found pretty good correlations — not perfect but they are pretty good — and that means that we are able to pick up meaningful differences in people, among people that we can tell someone who is eating a large amount
of transfat from a person eating low amount
of transfat.
In particular, he
studies the emergence
of the genetic code, the
biochemical interface by which organisms translate genetic instructions into living bodies.
A global analysis
of metabolites and small molecules in urine samples from patients with adrenal cancer has identified four
biochemicals that, when measured together, can distinguish malignant from benign adrenal tumors, according to
study results presented at the 2015 Annual Clinical Congress
of the American College
of Surgeons.
The researchers then used a battery
of behavioral and
biochemical tests to
study the mice after weaning.
The
study examined the effects
of smoking on various
biochemical processes in the blood and vessels
of 20 healthy non-smokers who volunteered to smoke three cigarettes.
The discovery
of an unexpected
biochemical link within tumor cells should lead to clinical trials for experimental drug treatments that indirectly target myc and that already are being evaluated in human
studies, the researchers said.
In the
study, the researchers show that after two to four weeks
of 3 - D culture, the resulting muscle cells form muscle fibers that contract and react to external stimuli such as electrical pulses and
biochemical signals mimicking neuronal inputs just like native muscle tissue.
The team
of researchers was the first in the world to use modern genetic, molecular and
biochemical methods to
study tooth enamel defects in detail.
Nucleic acid and protein sequences, as well as three - dimensional structures
of proteins, are frequently the objects
of study, but gene expression as well as the simulation
of pathways and
biochemical networks are attracting more and more attention.
In an effort to tease out a
biochemical pathway that might account for the clinical effects that Kaplan, Popper, and others had described, he ran a series
of rat
studies.
According to Dr Won Park, Inha University Hospital, Korea, and lead investigator
of the PLANETAS
study, «the challenge for biosimilars is to demonstrate similarity in therapeutic effectiveness, safety and immunogenicity to their reference product, not just
biochemical and pharmacokinetic equivalence.»
Bioprocess engineer Rafael Garcia
of ARS and
biochemical engineer Zhiyou Wen
of the Virginia Polytechnic Institute and State University in Blacksburg are designing a
study to grow EPA - and DHA - producing microbes using low - cost by - products
of other processes, such as glycerol from biodiesel production and rendered animal protein from slaughterhouses.
The beneficial effect
of SSRIs that has been shown in many
studies should thus, according to this theory, not be due to the fact that these drugs exert a specific
biochemical antidepressant action in the brain, but that the side effects
of the drugs enhance a psychological placebo effect.
A new Journal
of Neuroimaging
study provides insights into the
biochemical mechanisms by which Tai Chi — a mind - body exercise — may provide both physical and psychological benefits.
«This may reduce breast cancer risks by at least a half over 10 years,» says Mitch Dowsett, professor
of biochemical endocrinology at the Royal Marsden, and director
of the
study.
«Days after sockeye passed through extremely fast - moving water, we started to see fish dying only a short distance from their spawning grounds,» said Nicholas Burnett, a research biologist at UBC and lead author
of the
study, published in Physiological and
Biochemical Zoology.
Mirror - image versions
of such proteins would have the identical chemical characteristics as the natural protein (enabling detailed
biochemical studies), but will generally be non-toxic to natural organisms.
His current research uses a variety
of molecular,
biochemical, and genetic approaches to
study the basic biology
of mesenchymal stem cells (MSCs).
As part
of ENCODE, 32 institutions did computer analyses,
biochemical tests, and sequencing
studies on 147 cell types — six fairly extensively — to find out what each
of the genome's 3 billion bases does.
The researchers
studied the adhesion mechanisms using detailed
biochemical analyses and state -
of - the - art genetic systems, combined with unique H. pylori clinical strains and biopsy - materials collected from individual patients and animals over a span
of many years.
With VEGF - A and CEA, we believe we may have invented a test that can help that group
of patients who don't have a risk
of cancer get off the testing cycle and avoid surgery which, in and
of itself, has a risk
of mortality or complications,» said C. Max Schmidt, MD, PhD, FACS,
study author and professor
of surgery and
biochemical / molecular biology, Indiana University School
of Medicine.
They then conducted
biochemical analyses to identify neuroligin - 3, confirm that the protein could stimulate tumor growth in cultured samples
of several kinds
of human high - grade gliomas and
study which signals the protein uses within glioma cells to promote their growth.
Forward - looking
studies are examining other possible information couriers: glial cells (poorly understood brain cells that are 10 times as common as neurons), other kinds
of signaling mechanisms between cells (such as newly discovered gases and peptides), and the
biochemical cascades that take place inside cells.
There he
studied the fundamental cellular and
biochemical mechanisms required for immune cell activation and clearance
of infections.
The scientist Prof. Rupert Palme
of the Institute
of Medical Biochemistry at the University
of Veterinary Medicine, Vienna, was responsible for the
biochemical analysis
of the faecal samples in the
study.
Clark had always liked the idea
of international cooperation; he had been active since 1969 in planning summer school courses about molecular biology on the Greek island
of Spetses, which were funded by the Advanced
Study Institutes program
of NATO, the European Molecular Biology Organization, and the Federation
of European
Biochemical Societies.
«This is a significant example
of how knowing details
of potential mechanisms and the basic science
of redox active compounds in cancer versus normal cells can be leveraged clinically in cancer therapy,» says co-senior author Douglas Spitz, who focused on the
biochemical studies.
This
study revealed a way to indirectly mitigate the bad effects
of VEGF by activating a
biochemical chain
of events, or pathway, that suppresses the protein.
«While previous molecular
studies have provided simple snapshots
of the gene transcript variations that are associated with the exposure
of insects to natural and synthetic chemicals, the genomics approaches used in this
study offer a significantly more complex perspective on the
biochemical and physiological processes occurring in plant - insect interactions,» Schuler said.
Our
study represents another piece in the puzzle, since we provide an explanation for the protective
biochemical changes induced by physical exercise that prevent the brain from being damaged during stress,» says Mia Lindskog, researcher at the Department
of Neuroscience at Karolinska Institutet.
The elegant feedback system discovered in this
study links the regulation
of contraction to the shape and function
of epithelial tubes via mechanical and
biochemical signalling.